3,420 results match your criteria: "La Paz University Hospital.[Affiliation]"

Viscoelastic monitoring of direct oral anticoagulants (DOAC).

Blood Transfus

November 2024

Trauma Intensive Care Unit, Intensive Care Medicine Department, La Paz University Hospital, IdiPaz, Department of Medicine, Autonomous University of Madrid, Madrid, Spain.

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Background: The use of next-generation sequencing in inborn errors of immunity (IEI) has considerably increased the identification of novel gene variants, many of which are identified in patients without the described clinical phenotype or with variants of uncertain pathogenic significance in previously described genes. Properly designed functional and cellular assays, many necessarily accomplished by research-based laboratories, reveal the pathogenic consequences of the gene variants and contribute to diagnosis. Activated PI3Kδ syndrome (APDS) is a rare disease that can be divided into APDS1, caused by gain of function (GOF) mutations in gene, and APDS2, with loss of function (LOF) variants in the gene.

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Article Synopsis
  • - The study examined the prevalence of abdominal obesity (AO), high waist-to-height ratio (WtHR), and excess adiposity (EA) in a sample of 6,588 adults aged 18 to 102 years and their connections to cardiovascular-kidney-metabolic (CKM) syndrome factors.
  • - Results showed that 39.6% of participants had AO, 30.6% had high-WtHR, and 65.6% had EA, with higher rates observed in older individuals; key health issues like hypertension and diabetes were linked to these conditions.
  • - Findings indicate that a significant portion of the adult population experiences EA and AO, highlighting an independent association between these obesity metrics and other CKM syndrome factors
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Article Synopsis
  • The study examined how the timing of hip fracture surgery (time to surgery, TTS) affects the 30-day mortality rate in patients over 75 years old from the Spanish National Hip Fracture Registry.
  • It found that surgery within 2 days led to better outcomes, including lower mortality (5.4%) compared to surgery after 2 days (7.5%) and that longer TTS was associated with complications like pressure ulcers and increased hospital stay.
  • Overall, while there was a correlation between delayed surgery and higher mortality, the strength of this association was weak, indicating that other factors may also play a significant role in patient outcomes.
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Marburg virus disease outbreak in Rwanda, 2024.

Clin Microbiol Infect

November 2024

Emerging Infections Subcommittee, European Society of Clinical Microbiology and Infectious Disease, Switzerland; High-Level Isolation Unit, Infectious Diseases Unit, La Paz University Hospital, IdiPAZ, CIBERINFEC, Madrid, Spain.

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Background: The increasing availability of neuroimaging tests has led to a rise in the identification of incidental unruptured intracranial aneurysms (UIAs). Their management is under debate, with no consensus on their follow-up strategy, which can cause anxiety in patients. Our aim is to evaluate the impact of diagnosis and imaging follow-up on daily activities and quality of life.

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  • Fanconi anemia (FA) is a rare genetic disorder marked by varying symptoms and significant chromosome fragility, leading to severe health issues like cancer and bone marrow failure.
  • The Spanish Registry of Patients with FA gathered data from 227 patients over 30 years, revealing an 86% cumulative cancer incidence by age 50, with outcomes differing based on chromosome fragility and specific gene mutations.
  • Findings suggest that patients with mutations allowing some protein function (genetic hypomorphism) tend to have better health outcomes, indicating potential for new therapies that could enhance mutant FA protein function to improve patient prognosis.
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Article Synopsis
  • Bicuspid aortic valve (BAV) is a common congenital heart condition affecting 0.5-2% of the population and is linked to higher incidences in patients with severe aortic stenosis and older adults undergoing surgery.
  • Transcatheter aortic valve replacement (TAVR) is a new treatment option for aortic stenosis, but there's insufficient evidence to identify the best approach for patients with BAV.
  • The report discusses a case of severe acute recoil after TAVR with a self-expanding prosthesis in a patient with heavily calcified BAV and reviews the implications of prosthesis underexpansion in the medium term.
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Purpose: With the advent of biological therapies, emerging concepts regarding establishing new targets in asthma management, such as disease modification, have entered the debate among the scientific community. The definitions that form the conceptual basis of this goal need to be agreed upon.

Methods: A multidisciplinary expert group was assembled as the steering committee.

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Reflectance confocal microscopy for margin mapping of melanoma of the lentigo maligna type: A systematic review and meta-analysis.

J Eur Acad Dermatol Venereol

November 2024

Department of Dermatology, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Melanoma of the lentigo maligna (LM) type and its invasive counterpart, lentigo maligna melanoma (LMM), occur in chronically sun-damaged skin and tend to have subclinical extension that makes presurgical margin mapping challenging. Reflectance confocal microscopy (RCM) is a non-invasive imaging modality that enables in vivo visualization of the skin at the cellular level, allowing for adequate estimation of LM/LMM margins. We aimed to perform a systematic review and meta-analysis evaluating RCM's performance compared with histopathology in margin mapping of LM/LMM.

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Background: Hepatitis C virus (HCV) reinfection following successful treatment threatens the achievement of HCV elimination. The primary aim of this study is to assess reinfection rate three years after sustained virologic response (SVR) in people who inject drugs (PWID) that are on opioid agonist treatment (OAT) who underwent anti-HCV treatment with interferon-free regimens.

Methods: Observational, non-interventional, prospective, descriptive study carried out in Spanish tertiary public hospitals between 2017 and 2022.

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Objective: To assess the safety of fertility-sparing treatments for early-stage ovarian cancer in women younger than 40 years old.

Methods: We performed a retrospective multicenter study including women aged 18-40 years diagnosed with early-stage (FIGO I-II) ovarian cancer in 55 Spanish hospitals, from January 2010 to December 2019. Benign and borderline tumors were excluded, as well as advanced stages (FIGO III-IV).

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Background: Historically, perinatal depression has predominantly focussed on the mother-baby dyad, often neglecting the crucial role of fathers.

Aim: To determine the prevalence and associated factors of depressive symptoms in the immediate puerperium (PDS) in both mothers and fathers, individually and concurrently.

Method: This study employed a cross-sectional design.

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Occurrences of allergenicity to banana pathogenesis-related-10 (PR10) protein variants.

Food Funct

November 2024

Programme of Microbiology and Molecular Genetics, Institute of Biological Sciences, Faculty of Science, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.

Pathogenesis-related-10 (PR10) proteins play significant roles in plant defence against biotic and abiotic stresses. Recently, two banana PR10 proteins (MaPR10-BeB5 and MaPR10-GNA5) were characterised and shown to exhibit antifungal properties against . In rice, transgenic overexpression of PR10 proteins conferred resistance to pathogen infection and drought tolerance without affecting productivity, highlighting their potential for agricultural applications.

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The blood enzyme glutamate-oxaloacetate transaminase (GOT) has been postulated as an effective therapeutic to protect the brain during stroke. To demonstrate its potential clinical utility, a new human recombinant form of GOT (rGOT) was produced for medical use. We tested the pharmacokinetics and evaluated the protective efficacy of rGOT in rodent and non-human primate models that reflected clinical stroke conditions.

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Background: Advances in haemolytic disease of the fetus and newborn have led to numerous treatment options. We report practice variations in the management and outcomes of haemolytic disease of the fetus and newborn in at-risk pregnancies.

Methods: In this international, retrospective, observational cohort study, data from cases with moderate or severe haemolytic disease of the fetus and newborn were retrieved from 31 centres in 22 countries.

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Outcomes of Pediatric Hepatocellular Carcinoma: A Single-Center Experience With Resection Versus Transplantation.

Pediatr Transplant

December 2024

Division of Abdominal Organ Transplantation and Hepatobiliary Surgery, Department of Pediatric Surgery, La Paz University Hospital, Madrid, Spain.

Background: Pediatric hepatocellular carcinoma (HCC) presents significant challenges due to its aggressive nature, with survival depending on complete resection. We aimed to assess outcomes between liver resection (LR) and liver transplantation (LT).

Methods: A total of 25 patients were retrieved, four of whom were classified as palliative at diagnosis.

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Background: Concizumab is an anti-tissue factor pathway inhibitor monoclonal antibody in development as a once-daily, subcutaneous prophylaxis for patients with haemophilia A or haemophilia B with or without inhibitors. We aimed to assess the efficacy and safety of concizumab in patients with haemophilia A or B without inhibitors. Here we report the results from the confirmatory analysis cutoff.

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Gastric adenocarcinoma (GA) is a significant global health issue with poor prognosis, despite advancements in treatment. Although molecular classifications, such as The Cancer Genome Atlas (TCGA), provide valuable insights, their clinical utility remains limited. We performed a multi-layered functional analysis using TCGA RNA sequencing data to better define molecular subtypes and explore therapeutic implications.

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Cerebral near-infrared spectroscopy guided neonatal intensive care management for the preterm infant.

Pediatr Res

November 2024

University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Division of Neonatology, Groningen, The Netherlands.

Infants requiring admission to the neonatal intensive care unit (NICU) are particularly vulnerable to developing brain injury. The severity of the underlying clinical conditions and the complexity of care call for continuous, cot-side, non-invasive monitoring tools. Near-infrared spectroscopy (NIRS) measures the regional tissue oxygen saturation of hemoglobin (rStO) and provides continuous information on the net-result of several factors.

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