300 results match your criteria: "La Conception University Hospital[Affiliation]"

ChatGPT-4 performance in rhinology: A clinical case series.

Int Forum Allergy Rhinol

June 2024

Research Committee of Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies, Paris, France.

Chatbot Generative Pre-trained Transformer (ChatGPT)-4 indicated more than twice additional examinations than practitioners in the management of clinical cases in rhinology. The consistency between ChatGPT-4 and practitioner in the indication of additional examinations may significantly vary from one examination to another. The ChatGPT-4 proposed a plausible and correct primary diagnosis in 62.

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Endourological Management of Ureteral Stricture in Patients with Renal Transplant: A Systematic Review of Literature.

J Endourol

March 2024

Kidney Transplantation Working Group, European Association of Urology-Young Academic Urologists (EAU-YAU), Arnhem, The Netherlands.

To analyze the utility and outcomes of available endourologic options to treat ureteral stricture after kidney transplantation (KT). A systematic review was carried out for all English language articles from 2000 to 2023 according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) standards using EMBASE, MEDLINE, SCOPUS, Google scholar, and Cochrane library. The search term combination for the string was follows: [(Ureteral stricture) OR (ureter stenosis) OR (ureteral stenosis) OR (Stricture ureter) OR (Narrowing ureter) OR (Ureter restriction) OR (ureteral restriction) OR (ureteral narrowing) OR (ureteral obstruction) OR (ureter obstruction) OR (obstructing ureter) OR (obstructive ureter) OR (narrow ureter) OR (ureteral narrow)] AND [(kidney transplant) OR (transplanted kidney) OR (transplant) OR (transplantation)] AND [(management) OR (Robotic) OR (laser) OR (stent) OR (dilatation) OR (dilation) OR (endoscopic) OR (endourological) OR (Urologic) OR (laparoscopic) OR (surgery) OR (treatment)].

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Article Synopsis
  • Researchers wanted to see how well a special swallowing test called VFSS can find leaks in the throat after surgery to remove parts of the throat and voice box.
  • They looked at 248 patients who had this surgery and took the swallowing test about a week to two weeks later.
  • The test was pretty good at spotting leaks; it helped prevent future problems for many patients who had a positive test result.
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Influence of Otolaryngological Subspecialties on Perception of Transoral Robotic Surgery: An International YO-IFOS Survey.

J Pers Med

December 2023

Robotics Study Group of Young Otolaryngologists, International Federation of Oto-Rhino-Laryngological Societies, 75000 Paris, France.

Article Synopsis
  • The study investigates how otolaryngology and head and neck surgeons perceive, adopt, and are aware of transoral robotic surgery (TORS).
  • A survey of 359 surgeons revealed varied support for TORS among different subspecialties, with head and neck surgeons showing the most positive response, while laryngologists largely disagreed on its effectiveness.
  • Low adoption rates were largely attributed to concerns over the high costs associated with TORS, particularly among head and neck surgeons.
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Impact of a positive Chlamydia trachomatis serology on cumulative IVF live birth rate.

Reprod Biomed Online

February 2024

Department of Gynecology-Obstetric and Reproductive Medicine, Assistance Publique - Hôpitaux de Marseille, La Conception University Hospital, Aix-Marseille Univ, Marseille, France; IMBE, CNRS, IRD, Avignon Univ, Marseille, France.

Research Question: Does positive Chlamydia trachomatis serology have an impact on the cumulative live birth rate from IVF?

Design: A retrospective matched cohort study compared women with positive Chlamydia trachomatis serology (group A) who underwent IVF treatment between January 2016 and December 2021 with a control group of women with negative Chlamydia trachomatis serology (group B). The main outcome measures were the cumulative live birth rate per IVF cycle and the live birth rate per embryo transfer. Secondary outcomes were the cumulative rates of clinical pregnancy, ectopic pregnancy and pregnancy loss calculated per IVF cycle and per embryo transfer.

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Article Synopsis
  • The study focuses on male fertility preservation (FP) through sperm banking for men aged 15-49 diagnosed with testicular cancer (TC) or lymphomas (L) in France in 2018.
  • It analyzed data from the French National Cancer Institute and sperm banking centers, estimating sperm banking rates of 41% for TC, 40% for Hodgkin L, and 7% for non-Hodgkin L among diagnosed men.
  • The findings suggest a need for improved patient education and awareness to increase sperm banking rates and assess factors leading to the lack of sperm preservation before gonadotoxic treatments.
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The iliac fossa is the most commonly used site to place the graft in renal transplantation in adults. However, iliac fossa may not be used in various conditions. Thus, orthotopic renal transplantation becomes a viable alternative for these selected patients.

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Psychological Impact of Living Kidney Donation: A Systematic Review by the EAU-YAU Kidney Transplant Working Group.

Transpl Int

December 2023

Department of Urology and Renal Transplantation, La Conception University Hospital, Assistance Publique - Hôpitaux de Marseille, Aix-Marseille University, Marseille, France.

We performed a systematic literature review of the psychological impact on donors of living kidney donation. We conducted a literature review in PubMed/Medline according to PRISMA guidelines which included both qualitative (based on interviews) and quantitative studies (based on standardized questionnaire). There were 15 quantitative studies and 8 qualitative studies with 2,732 donors.

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Cross-cultural adaptation of the CRS-PRO questionnaire into French.

J Otolaryngol Head Neck Surg

December 2023

Service d'ORL et de chirurgie cervico-faciale, Centre Hospitalo-Universitaire de Montpellier, 80 Avenue Augustin Fliche, 34000, Montpellier, France.

Background: Chronic rhinosinusitis (CRS), encompasses many different clinical patterns with variable response to treatment. Precise criteria specifying disease severity and control are lacking in the current literature. Our aim was to perform a cross-cultural adaptation of the CRS-PRO, creating a French version for use as a routine questionnaire in the assessment of patients with CRS.

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Lifetime sexual violence experienced by women asylum seekers and refugees hosted in high-income countries: Literature review and meta-analysis.

J Forensic Leg Med

January 2024

Department of General Practice, Aix Marseille University, Marseille, France; Aix Marseille University, CEReSS, UR3279, Marseille, France. Electronic address:

Screening and care for victims of sexual violence (SV) among asylum seekers and refugees (ASRs) living in High-income host countries were prioritized by the WHO in 2020. The lack of stabilized prevalence findings on lifetime SV among ASRs in High-income countries hinders the development of adequate health management. The objective of this study was to determine the lifetime prevalence of SV experienced by ASRs living in High-income countries.

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Laryngeal office-based procedures: A safe approach.

Am J Otolaryngol

March 2024

ENT-HNS Department, Aix Marseille Univ, La Conception University Hospital, Marseille, France; Aix Marseille Univ, CNRS, LPL, Aix-en-Provence, France.

Purpose: Laryngeal surgeries using a flexible nasopharyngoscope equipped with an operative channel has gained popularity, with gradual increase in the variety of interventional office-based procedures, under local anesthesia. The purpose of this study is to analyze the tolerance of such procedures.

Materials And Methods: Retrospective cohort study.

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Robot-Assisted Radical Prostatectomy in Renal Transplant Recipients: A Systematic Review.

J Clin Med

October 2023

Unit of Uro-oncology and Kidney Transplant, Department of Urology, Puigvert Foundation, Universitat Autònoma de Barcelona (UAB), 08025 Barcelona, Spain.

Robot-assisted radical prostatectomy (RARP) has been shown to achieve excellent oncological outcomes with a low rate of complications in patients with prostate cancer. However, data on RARP in renal transplant recipients (RT) are dispersed. A literature search was conducted through April 2023 using PubMed/Medline, Embase and Web of Science databases.

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Purpose: Cut-off time to avoid orchiectomy relies on small series of patients. The objective was to determine the cut-off time to avoid orchiectomy in torsion of the spermatic cord in a large cohort.

Methods: We performed a retrospective multicenter study (TORSAFUF cohort) of patients with suspected spermatic cord torsion between 2005 and 2019.

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Biomarkers in Laryngeal Squamous Cell Carcinoma: The Literature Review.

Cancers (Basel)

October 2023

Section of Biochemistry, Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, 90127 Palermo, Italy.

Laryngeal squamous cell carcinoma (LSCC) is the second most common cancer among head and neck cancers. Despite a lower incidence of laryngeal carcinoma, new diagnostic techniques, and more targeted therapies, the overall survival has not changed significantly in the last decades, leading to a negative prognosis in advanced stages. Recently, several studies have focused on the identification of biomarkers that may play a critical role in the pathogenesis of LSCC.

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Laser Hair Removal for Intraoral Flaps: A Review.

Facial Plast Surg Aesthet Med

January 2024

Oral Surgery Department, APHM, INSERM, MMG, Aix Marseille University, Timone Hospital, Marseille, France.

Laser hair removal is a noninvasive technique that has been used for patients with oropharyngolaryngeal hair growth related to surgical flap reconstruction after head and neck cancer resection. The purpose of this work was to perform a rapid review of the literature to determine the therapeutic relevance of laser hair removal and identify laser parameters. A total of 10 publications addressing depilation of the head and neck sphere were selected and analyzed.

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Management of 80 sinonasal undifferentiated carcinomas. Retrospective multicentre study of the French Network of Rare Head and Neck Cancers (REFCOR).

Eur J Surg Oncol

December 2023

Department of Radiation Oncology, Bordeaux University Hospital, F33000, Bordeaux, France; Bordeaux University, na unit, UMR 6033, F-33000, Bordeaux, France; BRIC (BoRdeaux Institute of OnCology), UMR1312, INSERM, University of Bordeaux, F-33000, Bordeaux, France. Electronic address:

Objectives: Sinonasal undifferentiated carcinoma (SNUC) is a rare and aggressive disease requiring multimodal treatment, and multiple new entities once included in the spectrum of SNUC, such as SWI/SNF-deficient carcinomas, are emerging. We aimed to provide new data regarding the role of chemotherapy and surgery and the prognostic factors of disease-free survival.

Methods: This study was based on data from the REFCOR database and included patients with SNUC treated with curative intent from 2007 to 2021 across 22 centres in France.

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Molecular Basis and Natural History of Medullary Thyroid Cancer: It is (Almost) All in the .

Cancers (Basel)

October 2023

Aix Marseille Univ, APHM, INSERM, MMG, La Conception University Hospital, Laboratory of Molecular Biology, Marseille, France.

Medullary thyroid cancer (MTC) is a rare disease, which can be either sporadic (roughly 75% of cases) or genetically determined (multiple endocrine neoplasia type 2, due to REarranged during Transfection germline mutations, 25% of cases). Interestingly, pathogenic variants (mainly M918T) have also been reported in aggressive forms of sporadic MTC, suggesting the importance of signalling pathways in the pathogenesis of MTC. The initial theory of codon-related MTC aggressiveness has been recently questioned by studies suggesting that this would only define the age at disease onset rather than the aggressiveness of MTC.

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The aim of our study was to evaluate the feasibility and efficiency of delayed ovarian stimulation and metaphase II oocyte banking for fertility preservation after fertility-impairing treatment regardless of the initial disease. We conducted a cohort study based on population of women < 40 years of age with diminished ovarian reserve caused by fertility-impairing treatment (n = 129). Three groups of women were compared according to the type of initial disease: hematological malignancies, solid tumors, and benign diseases.

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Cytidine deaminase status as a marker of response to azacytidine treatment in MDS and AML patients.

Br J Haematol

November 2023

SMARTc: Simulation and Modeling: Adaptative Response for Therapeutics in Cancer, Faculté de Pharmacie de Marseille, CRCM Inserm UMR 1068, Marseille, France.

Azacitidine (Aza) is a mainstay of treatment for patients with acute myeloid leukaemia (AML) ineligible for induction chemotherapy and other high-risk myelodysplastic syndromes (MDS). Only half of patients respond, and almost all will eventually relapse. There are no predictive markers of response to Aza.

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Context: In an increasingly ageing transplant population, timely management of benign prostatic obstruction (BPO) is key to preventing complications that result in graft dysfunction or compromise survival.

Objective: To evaluate benefits/harms of BPO treatments in transplant patients by reviewing current literature.

Evidence Acquisition: A computerised bibliographic search of Medline, Embase, and Cochrane databases was performed for studies reporting outcomes on BPO treatments in transplanted patients.

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Effectiveness and rapidity on olfatory fuction recovery in CRS patients treated with Dupilumab: a real life prospective controlled study.

Eur Arch Otorhinolaryngol

January 2024

Department of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia" ENT Section, University of Catania, 95123, Catania, Italy.

Background: Recovery of olfactory function plays a prominent role in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). While rates and timing of such recovery vary, monoclonal antibodies might yield better results which we aimed at evaluating with this study.

Methodology: A prospective controlled study was conducted at our tertiary otolaryngological center from April 1, 2021, to October 1, 2022, in CRSwNP patients.

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Effectiveness of Platelet-Rich Plasma for COVID-19-Related Olfactory Dysfunction: A Controlled Study.

Otolaryngol Head Neck Surg

January 2024

Department of Otorhinolaryngology and Head and Neck Surgery, APHM, IUSTI, CNRS, La Conception University Hospital, Aix Marseille University, Marseille, France.

Objective: To investigate the effectiveness of platelet-rich plasma (PRP) injection into the olfactory clefts of coronavirus disease 2019 (COVID-19) patients with persistent olfactory dysfunction (OD).

Study Design: Controlled study.

Setting: Multicenter study.

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Non-Squamous Cell Carcinoma of the Larynx: A State-of-the-Art Review.

J Pers Med

June 2023

Head & Neck Study Group, Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), 13005 Marseille, France.

(1) Background: Non-squamous cell laryngeal carcinoma includes endothelial tumors, such as minor salivary gland tumors, lymphoepithelial tumors, neuroendocrine tumors, soft and hard tissue sarcomas, and malignant melanomas. (2) Methods: A state-of-the-art review using the MEDLINE/PUBMED, Google Scholar, Ovid Medline, Embase, and Scopus electronic databases was performed. (3) Conclusions: In order to optimize overall treatment outcomes, a multidisciplinary, patient-centered approach to the management of non-SCC of the larynx must be adopted universally; a national or international registry on non-SCC laryngeal cancer can be useful to improve understanding about the behavior of this kind of tumor.

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Pediatric Inferior Turbinate Hypertrophy: Diagnosis and Management. A YO-IFOS Consensus Statement.

Laryngoscope

March 2024

Young Otolaryngologists-International Federation of Otorhinolaryngological Societies, Paris, France.

Objective: Pediatric inferior turbinate hypertrophy (PedTH) is a frequent and often overlooked cause or associated cause of nasal breathing difficulties. This clinical consensus statement (CCS) aims to provide a diagnosis and management framework covering the lack of specific guidelines for this condition and addressing the existing controversies.

Methods: A clinical consensus statement (CCS) was developed by a panel of 20 contributors from 7 different European and North American countries using the modified Delphi method.

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