Clinically Relevant Deficits in Performance Tests in Patients With Axial Spondyloarthritis.

Objective: To assess the association between self-reported and performance-based physical functioning and to evaluate which performance tests are most frequently impaired in patients with axial spondyloarthritis (axSpA).

Methods: Consecutive patients with axSpA underwent standardized assessments including patient and disease characteristics; patient-reported outcomes for disease activity, functioning, depression, mobility, and physical activity; and performance tests. Patients were defined as being impaired if they were not able to perform ≥ 1 of the performance tests.

Systemic treatment in advanced phyllodes tumor of the breast: a multi-institutional European retrospective case-series analyses.

Background: We aimed at investigating outcome of systemic treatments in advanced breast PT.

Methods: All cases of advanced breast PT treated with systemic treatments from 1999 to 2019, in one of the referral sarcoma centers involved in the study, were retrospectively reviewed.

Results: 56 female patients were identified.

ABO-incompatible kidney transplantation in perspective of deceased donor transplantation and induction strategies: a propensity-matched analysis.

Kidney transplant candidates are blood group incompatible with roughly one out of three potential living donors. We compared outcomes after ABO-incompatible (ABOi) kidney transplantation with matched ABO-compatible (ABOc) living and deceased donor transplantation and analyzed different induction regimens. We performed a retrospective study with propensity matching and compared patient and death-censored graft survival after ABOi versus ABOc living donor and deceased donor kidney transplantation in a nationwide registry from 2006 till 2019.

Dead in the Night: Sleep-Wake and Time-Of-Day Influences on Sudden Unexpected Death in Epilepsy.

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related death in patients with refractory epilepsy. Convergent lines of evidence suggest that SUDEP occurs due to seizure induced perturbation of respiratory, cardiac, and electrocerebral function as well as potential predisposing factors. It is consistently observed that SUDEP happens more during the night and the early hours of the morning.

Favourable outcomes of a preventive screening and counselling programme for older people in underprivileged areas in the Netherlands: The PRIMUS project.

An aging population is associated with an increased prevalence of diabetes, cardiovascular diseases and depression. Important aspects of programmes targeted at older people are: to reach those at risk, effective screening, optimising advice, and referral to local interventions. We examined the effect of a preventive health consultation (PRIMUS), a multi-behavioural screening programme for persons aged 55-74 years in primary care.

Nano-medicine Improving the Bioavailability of Small Molecules for the Prevention of Neurodegenerative Diseases.

Neurodegenerative diseases, including Parkinson's and Alzheimer's, are a heterogeneous group of brain disorders characterized by the progressive degeneration of the structure and function of the central or peripheral nervous system. It is thought that the number of people affected by these pathologies will increase in future decades, particularly in the more economically developed countries, where the populations are experiencing a demographic shift towards older ages. For many of these pathologies, and in particular for Alzheimer's disease, no effective treatments are available, and the consequent economic and social costs are very high.

Prone sleeping and SUDEP risk: The dynamics of body positions in nonfatal convulsive seizures.

Background: Most victims of sudden unexpected death in epilepsy (SUDEP) are found prone with signs suggestive of an unwitnessed convulsive seizure (CS). Prone sleeping has been proposed as a risk factor for SUDEP. Little is known, however, about the change of body position during the course of CSs.

Development and preliminary validation of an Observation List for detecting mental disorders and social Problems in the elderly in primary and home care (OLP).

Objective: Even though the prevalence of mental disorders and social problems is high among elderly patients, it is difficult to detect these in a primary (home) care setting. Goal was the development and preliminary validation of a short observation list to detect six problem areas: anxiety, depression, cognition, suspicion, loneliness, and somatisation.

Methods: A draft list of indicators identified from a short review of the literature and the opinions of 22 experts was evaluated by general practitioners (GPs) and home care organisations for feasibility.

Sudden cardiac arrest in people with epilepsy in the community: Circumstances and risk factors.

Objective: To ascertain whether characteristics of ventricular tachycardia/fibrillation (VT/VF) differed between people with epilepsy and those without and which individuals with epilepsy were at highest risk.

Methods: We ascertained 18 people with active epilepsy identified in a community-based registry of sudden cardiac arrest (SCA) with ECG-confirmed VT/VF (cases). We compared them with 470 individuals with VT/VF without epilepsy (VT/VF controls) and 54 individuals with epilepsy without VT/VF (epilepsy controls).

Increased prevalence of ECG markers for sudden cardiac arrest in refractory epilepsy.

Background And Aim: People with epilepsy are at increased risk of sudden cardiac arrest (SCA) due to ECG-confirmed ventricular tachycardia/fibrillation, as seen in a community-based study. We aimed to determine whether ECG-risk markers of SCA are more prevalent in people with epilepsy.

Methods: In a cross-sectional, retrospective study, we analysed the ECG recordings of 185 people with refractory epilepsy and 178 controls without epilepsy.

Self-reported psychopathic traits in sexually offending juveniles compared with generally offending juveniles and general population youth.

The aim of the current study is to gain a better insight into the relationship between sexually aggressive behaviour and psychopathy in youths; juveniles who sexually offended (JSOs) were compared with generally offending youths and a general population group. Seventy-one JSOs, 416 detained general offenders, and 331 males from the general population were assessed by means of the Youth Psychopathic traits Inventory (YPI), a self-report instrument. Sexually and generally offending juveniles had significantly lower levels of self-reported psychopathic traits than youths from the general population.

Postictal generalized EEG suppression: an inconsistent finding in people with multiple seizures.

Objective: To determine the consistency and facilitating cofactors of postictal generalized EEG suppression (PGES) of >20 seconds after convulsive seizures (CS), a suggested predictor of sudden unexpected death in epilepsy risk.

Methods: We retrospectively reviewed video-EEG data of people with ≥2 recorded CS. Presence and duration of PGES were assessed by 2 independent observers blinded to patient status.

Psychotic-like symptoms as a risk factor of violent recidivism in detained male adolescents.

The aim of this study was to prospectively examine whether psychotic-like symptoms (PLSs) are positively associated with violent recidivism and whether this relation is stronger when PLSs co-occur with substance use disorders (SUDs). Participants were 224 detained male adolescents from all youth detention centers in Flanders. The Diagnostic Interview Schedule for Children was used to assess PLSs and the number of SUDs.

Psychopathic-like traits among detained female adolescents: reliability and validity of the Antisocial Process Screening Device and the Youth Psychopathic Traits Inventory.

This study examined the factor structure, reliability, and validity of the Antisocial Process Screening Device-Self-Report (APSD-SR), the Youth Psychopathic Traits Inventory (YPI), and the YPI-Short Version (YPI-SV) in detained female adolescents aged 12 to 17 years. The proposed three-factor structure of the YPI and YPI-SV was replicated, whereas the proposed three-factor structure of the APSD-SR or alternate models did not yield adequate fit. Overall, reliability indices for the YPI and YPI-SV were higher than those reported for the APSD-SR.

Youth Psychopathic Traits Inventory-Short Version: A Further Test of the Internal Consistency and Criterion Validity.

The Youth Psychopathic Traits Inventory-Short Version (YPI-S; van Baardewijk et al., 2010) is a self-report measure to assess psychopathic-like traits in adolescents. The aim of the present study is to investigate the factor structure, the internal consistency, and the criterion validity of the YPI-S in 768 Belgian community adolescents (45.

The predictive value of low heart rate and heart rate variability during stress for reoffending in delinquent male adolescents.

Low autonomic (re)activity is a consistent correlate of antisocial behavior in juveniles. However, longitudinal research relating autonomic measures to persistent antisocial behavior has remained scarce. Therefore, in the present study we examined the predictive value of heart rate (HR) and heart rate variability (HRV, often studied as respiratory sinus arrhythmia) for reoffending in delinquent male adolescents.