3 results match your criteria: "LLC "Center for Molecular Health"[Affiliation]"
Features of Metabolism and Its Regulation in the Dynamics of Experimental Models of Metabolic Disorders.
Bull Exp Biol Med
December 2024
Center for Digital and Translational Biomedicine, Center for Molecular Health LLC, Moscow, Russia.
Article Synopsis
- The study examined lipid and carbohydrate metabolism as well as adipokines and growth factors in three mouse models with different metabolic disorders: alimentary obesity, leptin-resistant obesity, and diabetes mellitus.
- In the alimentary obesity model, mice showed moderate liver fat, enlarged adipose tissue, and elevated levels of glucose, adiponectin, and cholesterol.
- In the leptin-resistant model, severe tissue issues were noted, along with high blood sugar and leptin but low triglycerides and certain growth factors.
- The diabetes mellitus model revealed a decrease in insulin-producing cells and lower levels of important hormones like adiponectin and leptin, along with high insulin levels.
Changes of the Concentration of Short-Chain Fatty Acids in the Intestines of Mice with Different Types of Obesity.
Bull Exp Biol Med
January 2024
Center of Digital and Translational Biomedicine, LLC "Center for Molecular Health", Moscow, Russia.
We studied the production of short-chain fatty acids (SCFA) by the intestinal microbiota in mice with obesity caused by a diet and a genetic defect in the leptin receptor gene. In mice, intestinal contents were examined and SCFA were quantitatively assayed by gas chromatography. SCFA concentration in the intestinal contents of mice with alimentary obesity model was significantly lower in the first phase of the experiment (day 14), and the change in their production in dynamics was fundamentally different from this process in the control group (standard diet).
View Article and Find Full Text PDFThe Effect of TLR Agonists and Myokines on Secretory Activity of Adipogenically Differentiated MSC Cultures.
Bull Exp Biol Med
October 2021
N. I. Pirogov Russian National Research Medical University, Ministry of the Health of the Russian Federation, Moscow, Russia.
We studied the effect of bacterial pathogen-associated molecular patterns and myokines on the secretion of adipokines by mesenchymal stem cells (MSC) and products of their adipogenic differentiation. The secretion of adiponectin, adipsin, leptin, and insulin by adipogenically differentiated cell cultures was quantitatively determined using multiplex ELISA. MSC obtained from the stromal vascular fraction of human subcutaneous adipose tissue were shown to secrete a known adipokine adipsin.
View Article and Find Full Text PDF