Factors related to seeking health care among adolescents with musculoskeletal pain.

Musculoskeletal pain is common among adolescents, but little is known about the factors that affect seeking health care for the problem. We examined the care-seeking pattern among adolescents reporting musculoskeletal pain. The study consisted of adolescents aged 16 years from the 1986 Northern Finland Birth Cohort who responded to a mailed questionnaire in 2001 and reported musculoskeletal pain over the preceding 6 months (n=5052).

Suspected motor problems and low preference for active play in childhood are associated with physical inactivity and low fitness in adolescence.

Background: This prospective longitudinal study investigates whether suspected motor problems and low preference for active play in childhood are associated with physical inactivity and low cardiorespiratory fitness in adolescence.

Methodology/principal Findings: The study sample consisted of the Northern Finland Birth Cohort 1986 (NFBC 1986) composed of 5,767 children whose parents responded to a postal inquiry concerning their children's motor skills at age 8 years and who themselves reported their physical activity at age 16 years. Cardiorespiratory fitness was measured with a cycle ergometer test at age 16 years.

Sustained involvement in youth sports activities predicts reduced chronic job strain in early midlife.

Objective: We examined the long-term effects of youth leisure time physical activity (LTPA) and sports participation on the prevalence of chronic work stress in adulthood.

Methods: Participants (326 men and 338 women) aged 9 to 18 years were initially enrolled in 1980 and followed until 2007. Data were collected using questionnaires and bicycle ergometry in a subgroup.

Leadership component of type A behavior predicts physical activity in early midlife.

Background: Research on the long-term effects of Type A behavior and its components in the prediction of physical activity in adulthood is scarce and there is a lack of prospective data that are able to show such an association.

Purpose: We examined the relations between components of Type A behavior and physical activity from youth to early midlife.

Method: The sample included 2,031 participants (43.

Sedentary lifestyle and emergence of hopelessness in middle-aged men.

Background: A sedentary lifestyle and psychosocial factors such as hopelessness and depression increase cardiovascular risk. Cross-sectional evidence suggests positive effects of physical exercise on psychological well being, but the time order of the relationship between physical activity and hopelessness has not been addressed.

Design: Population-based prospective cohort study with 630 middle-aged men participating in the 4-year follow-up and 509 men in the 11-year follow-up.

Sustained participation in youth sport decreases metabolic syndrome in adulthood.

Objective: to explore the effect of organized youth sport on metabolic syndrome (MetS) in adulthood.

Design: Longitudinal study data from the cardiovascular risk in young Finns study.

Subjects: A total of 1493 males (n=704) and females (n=789) aged 3, 6, 9, 12, 15 and 18 years were randomly selected from five university towns and their rural surroundings in 1980.

The longitudinal effects of physical activity history on metabolic syndrome.

Purpose: To examine the relationship of physical activity and its changes over a 9-yr follow-up to the prevalence of metabolic syndrome (MetS) in 2060 young adults (24-39 yr) enrolled in the Cardiovascular Risk in Young Finns Study.

Methods: Leisure-time physical activity (LTPA) was assessed using a self-report questionnaire completed in connection with a medical examination at two consecutive measurements in 1992 and 2001. By summing the LTPA items, a physical activity index (PAI) was formed for both measurement points according to which the participants were divided into tracking groups: persistently active, increasingly active, decreasingly active, and persistently inactive.

Exercise-induced expression of angiogenic growth factors in skeletal muscle and in capillaries of healthy and diabetic mice.

Background: Diabetes has negative, and exercise training positive, effects on the skeletal muscle vasculature, but the mechanisms are not yet fully understood. In the present experiment the effects of running exercise on the mRNA expression of pro- and antiangiogenic factors were studied in healthy and diabetic skeletal muscle. The responses in capillaries and muscle fibers, collected from the muscle with laser capture microdissection, were also studied separately.

Effects of acute exercise, exercise training, and diabetes on the expression of lymphangiogenic growth factors and lymphatic vessels in skeletal muscle.

Blood and lymphatic vessels together form the circulatory system, allowing the passage of fluids and molecules within the body. Recently we showed that lymphatic capillaries are also found in the capillary bed of skeletal muscle. Exercise is known to induce angiogenesis in skeletal muscle, but it is not known whether exercise has effects on lymphangiogenesis or lymphangiogenic growth factors.

A single bout of exercise with high mechanical loading induces the expression of Cyr61/CCN1 and CTGF/CCN2 in human skeletal muscle.

High mechanical loading was hypothesized to induce the expression of angiogenic and/or lymphangiogenic extracellular matrix (ECM) proteins in skeletal muscle. Eight men performed a strenuous exercise protocol, which consisted of 100 unilateral maximal drop jumps followed by submaximal jumping until exhaustion. Muscle biopsies were taken 30 min and 48 h postexercise from the vastus lateralis muscle and analyzed for the following parameters: mRNA and protein expression of ECM-associated CCN proteins [cysteine-rich angiogenic protein 61 (Cyr61)/CCN1, connective tissue growth factor (CTGF)/CCN2], and mRNA expression of vascular endothelial growth factors (VEGFs) and hypoxia-inducible factor-1alpha.

Repeated bout effect on the cytoskeletal proteins titin, desmin, and dystrophin in rat skeletal muscle.

The aim of this study was to evaluate the effect of repeated bouts of exercise on the cytoskeletal proteins titin, desmin, and dystrophin. Rats were made to run downhill for 90 min 1 or 5 times separated by 14 days. Samples were taken from quadriceps femoris muscle 3, 48, 96 h and 50 days after the last exercise session and detected by quantitative PCR, histochemical stainings, and western blot analyses.

Effects of streptozotocin-induced diabetes and physical training on gene expression of titin-based stretch-sensing complexes in mouse striated muscle.

In striated muscle, a sarcomeric noncontractile protein, titin, is proposed to form the backbone of the stress- and strain-sensing structures. We investigated the effects of diabetes, physical training, and their combination on the gene expression of proteins of putative titin stretch-sensing complexes in skeletal and cardiac muscle. Mice were divided into control (C), training (T), streptozotocin-induced diabetic (D), and diabetic training (DT) groups.

Effects of experimental type 1 diabetes and exercise training on angiogenic gene expression and capillarization in skeletal muscle.

Diabetes alters microvascular structure and function and is a major risk factor for cardiovascular diseases. In diabetic skeletal muscle, impaired angiogenesis and reduced VEGF-A expression have been observed, whereas in healthy muscle exercise is known to have opposite effects. We studied the effects of type 1 diabetes and combined exercise training on angiogenic mRNA expression and capillarization in mouse skeletal muscle.

Stability and prediction of physical activity in 5-, 10-, and 28-year follow-up studies among industrial employees.

The aim of the study was to examine the stability of voluntary and household physical activity (PA) and to compare it with that of the use of the most common stimulants. The prospective cohort study comprised of follow-ups at 5, 10, and 28 years at baseline in 1973 in four plants of an industrial corporation in Finland. A systematic, non-proportional sample (n=902, age range 18-64 years) stratified for age, gender, and occupational status was drawn from the employees.

Effects of streptozotocin-induced diabetes and physical training on gene expression of extracellular matrix proteins in mouse skeletal muscle.

Diabetes induces changes in the structure and function of the extracellular matrix (ECM) in many tissues. We investigated the effects of diabetes, physical training, and their combination on the gene expression of ECM proteins in skeletal muscle. Mice were divided to control (C), training (T), streptozotocin-induced diabetic (D), and diabetic training (DT) groups.

Injuries to the upper extremity in ice hockey: analysis of a series of 760 injuries.

Background: Injuries to the upper extremity are common in ice hockey.

Purpose: To investigate the mechanisms, types, and severity of upper extremity ice hockey injuries in patients in different age categories.

Study Design: Retrospective cohort study.

Physical activity and breast cancer risk among female physical education and language teachers: a 34-year follow-up.

The cohort consisted of 1,489 Finnish female physical education and 8,560 language teachers born after 1920 and alive in 1967. The 2 study populations were similar in social class and way of living and clearly discordant in physical activity both during their university studies and later in life. The incidence of breast cancer among these teachers up to the year 2000 was assessed through a record linkage with the Finnish Cancer Registry.

Standardization and validation of the body weight adjustment regression equations in Olympic weightlifting.

The problems in comparing the performances of Olympic weightlifters arise from the fact that the relationship between body weight and weightlifting results is not linear. In the present study, this relationship was examined by using a nonparametric curve fitting technique of robust locally weighted regression (LOWESS) on relatively large data sets of the weightlifting results made in top international competitions. Power function formulas were derived from the fitted LOWESS values to represent the relationship between the 2 variables in a way that directly compares the snatch, clean-and-jerk, and total weightlifting results of a given athlete with those of the world-class weightlifters (golden standards).

Injury profile in ice hockey from the 1970s through the 1990s in Finland.

The aim of this study was to investigate the incidence, types, and mechanisms of injury in Finnish ice hockey players at the highest competition level in different decades. Several teams were observed prospectively during the seasons between 1976 and 1979, and in the 1988 to 1989 and 1992 to 1993 seasons. An injury was defined as any sudden trauma requiring examination and treatment by a physician.

Controlled lengthening or shortening contraction-induced damage is followed by fiber hypertrophy in rat skeletal muscle.

To study the hypothesis that more severe damage, caused by controlled lengthening (L) contractions, results in greater myofiber hypertrophy compared to increase in fiber size followed shortening (S) contractions, tibialis anterior muscles of anesthesized male Wistar rats were subjected to 240 either L or S contractions. The highest increase in muscle beta-glucuronidase activity, an indicator of muscle damage, was observed in L (7.1-fold) 4 days and in S (2.

Neck muscle ultrasonography of male weight-lifters, wrestlers and controls.

The purpose of this cross-sectional study was to evaluate the effect of different sport training regimens on the size of the neck semispinalis capitis muscle (SECM). The cross-sectional area (CSA) and the linear dimensions of the SECM were measured bilaterally by real-time ultrasonography. Ten young Finnish elite level weight-lifters, 8 freestyle wrestlers and 10 controls (all male) participated in the study.

Gender differences in skeletal muscle fibre damage after eccentrically biased downhill running in rats.

Specific antibodies against structural proteins of muscle fibres (actin, desmin, dystrophin) and extracellular matrix (fibronectin) were used to study the effect of eccentrically biased downhill running exercise (13,5 degrees, 17 m min(-1), 130 min) on the magnitude and properties of myofibre injury in the quadriceps femoris muscle of male and female rats. Muscle beta-glucuronidase activity, a quantitative indicator of muscle damage, showed clearly smaller increase in female than in male rats during the 4-day period following exercise. A similar course of histopathological changes was observed in both sexes, although females showed slower and less marked changes than males.

The disruption of myofibre structures in rat skeletal muscle after forced lengthening contractions.

Specific antibodies against structural proteins (actin, desmin, dystrophin, fibronectin) of muscle fibres were used to study the effect of forced lengthening contractions on muscle microarchitecture. Tibialis anterior (TA) muscle of male Wistar rats were subjected to 240 forced lengthening contractions. At consecutive time points (0, and 6 h, 2, 4, and 7 days) after stimulation, the TA muscle was excised for biochemical and histological assays.

Neck semispinalis capitis muscle size in sitting and prone positions measured by real-time ultrasonography.

Objective: To examine the reliability of measurements of semispinalis capitis muscle (SECM) cross-sectional area (CSA) in prone and sitting positions, and to compare the muscle size in these two positions.

Design: Semispinalis capitis CSA was measured twice a day on two successive days with a real-time ultrasound apparatus.

Subjects: Eighteen males (aged 19-34 years) and 28 females (aged 19-34 years) were studied for the reliability test.

Ice hockey injuries in Finland. A prospective epidemiologic study.

In this prospective study of ice hockey injuries in Finland we have investigated the incidence of injury at two playing levels and the causal factors, mechanisms, types, and consequences of the injuries. Seven Finnish ice hockey teams were observed during the 1988 to 1989 season. There were a total of 189 injuries.