"Am I the only one who will Spread the Virus?": Impact of Public Stigma Towards the East Asian Population Living in Spain Related to COVID-19.

Previous studies have suggested that COVID-19 led to an increase in stigma towards the Asian population with a negative impact on their health. This study aims to explore this phenomenon and its impact on health through the qualitative analysis of semi-structured interviews conducted with 26 people of Asian origin living in Spain from September 2020 to September 2021. Among the results, it was found that, prior to the pandemic, discrimination was mostly verbal.

Identification and characterization of GRAS genes in passion fruit (Passiflora edulis Sims) revealed their roles in development regulation and stress response.

Twenty-nine GRAS genes were identified in passion fruit, the N-terminal regions and 3D (three-dimensional) structures were closely related with their tissue-specific expression patterns. Candidate PeGRASs for enhancing stress resistance were identified. Passion fruit (Passiflora edulis Sims) is a tropical fruit crop with significant edible and ornamental value, but its growth and development are highly sensitive to environmental conditions.

Changes in physical activity since cancer diagnosis and associations with health-related quality of life: a study of adults living with advanced cancer.

Purpose: Physical activity (PA) is associated with better quality of life for cancer survivors; however, less is known about this association among individuals with advanced cancer. This study assesses whether changes in PA following an advanced cancer diagnosis are associated with health-related quality of life (HRQoL) outcomes.

Methods: Data were collected from 247 participants in a survey of adults with advanced cancer who visited the University of Wisconsin Carbone Cancer Center (January 2021-2023).

Dihydropyrimidine Dehydrogenase Deficiency (DPYD) Genotyping-Guided Fluoropyrimidine-Based Adjuvant Chemotherapy for Breast Cancer. A Cost-Effectiveness Analysis.

Background And Objective: While standard doses of adjuvant fluoropyrimidine-based chemotherapies are generally safe for most patients, the risk of severe adverse drug reactions (ADRs) is increased for those with dihydropyrimidine dehydrogenase deficiency (DPYD), a genetic variation that affects drug metabolism. The objective of this study was to examine the cost effectiveness of offering DPYD pharmacogenetic-guided care, where genetic testing informs personalized dosing versus the current standard of care (SoC), which involves administering fluoropyrimidine-based therapies without prior genetic screening, for local or metastatic breast cancer patients in Qatar.

Methods: We developed a two-stage decision analysis, with an analytic tree model over a 6-month period, followed by a life-table Markov model over a lifetime horizon.

Physiological impact of secondary nanoplastics on aquatic inhabitants in special reference to immunotoxicity.

Nanoplastic (NP) pollution poses serious health hazards to aquatic ecosystems, impacting various physiological systems of aquatic organisms. This review examines the complex interplay between NPs and different physiological systems. In the digestive system, NPs downregulate the hsp70-like gene in Mytilus galloprovincialis, leading to decreased metabolic processes and impaired digestion.

Extraction, Annotation, and Purification of Resin Glycosides from the Morning Glory Family (Convolvulaceae).

The metabolic diversity of plants, comprising over a million different metabolites across the plant kingdom, harbors enormous potential for pharmaceutical and biotechnological applications. Resin glycoside (RG) acylsugars from the Convolvulaceae are of interest due to their medicinal and agricultural potential. However, understanding the biological relevance of RGs is challenging as they exhibit a high lineage-specific structural diversity.

Dexmedetomidine alleviates acute kidney injury in a rat model of veno-arterial extracorporeal membrane oxygenation.

Background: Although extracorporeal membrane oxygenation (ECMO) is an effective technique for life support, the incidence of acute kidney injury (AKI) during ECMO support remains high. Dexmedetomidine (DEX), which has been widely used for sedation during ECMO, possesses several properties that help reduce the occurrence of AKI. This study aimed to investigate the protective effect of DEX on kidney function during ECMO.

Neuroprotective effects of phytochemicals through autophagy modulation in ischemic stroke.

Stroke is a serious life-threatening medical condition. Understanding the underlying molecular mechanisms of this condition is crucial to identifying novel therapeutic targets that can improve patient outcomes. Autophagy is an essential mechanism for the destruction of damaged intracellular components that maintains homeostasis in physiological or pathological conditions.

Environmental impact analysis of crop residue burning in Madhya Pradesh: A multivariate comparison across key crops.

This study quantified the environmental impacts of residue burning of major produced and burned crops in Madhya Pradesh, central India. The environmental impacts were quantified using Life Cycle Assessment (LCA) coupled with Monte Carlo simulation of 1000 iterations. Crop wise marginal impacts of the crops have been quantified using Multivariate regression model.

Society for Cardiovascular Magnetic Resonance recommendations toward environmentally sustainable cardiovascular magnetic resonance.

Delivery of health care, including medical imaging, generates substantial global greenhouse gas emissions. The cardiovascular magnetic resonance (CMR) community has an opportunity to decrease our carbon footprint, mitigate the effects of the climate crisis, and develop resiliency to current and future impacts of climate change. The goal of this document is to review and recommend actions and strategies to allow for CMR operation with improved sustainability, including efficient CMR protocols and CMR imaging workflow strategies for reducing greenhouse gas emissions, energy, and waste, and to decrease reliance on finite resources, including helium and waterbody contamination by gadolinium-based contrast agents.

Exploring the lived experiences of diagnostic radiographers after transitioning to non-emergency imaging settings.

Introduction: The demand for diagnostic imaging in emergency clinical settings has increased in recent years, placing pressure on the available workforce. However, challenges including staff shortages and inflexible shift patterns may prompt radiographers to leave emergency settings. This study explores the lived experiences of radiographers who have transitioned to non-emergency settings and factors that might influence their decision to return.

Transcellular regulation of ETI-induced cell death.

To address the persistent challenge of cell death spread and limitation during effector-triggered immunity (ETI), we propose a 'concentric circle' model. This model outlines a regulatory framework, integrating multiple cells and diverse signaling molecules, including salicylic acid (SA), jasmonic acid (JA), and Ca. By accounting for the varying concentrations and spatiotemporal distributions of these molecules, our model aims for precision in immune defense and regulated cell death.

Analysis of correlations between health-related quality of life and clinical measures after arthroscopic lysis and lavage of the temporomandibular joint.

How well patient perceived outcome reflects clinical measurements after arthroscopic lysis and lavage of the temporomandibular joint (TMJ) is not fully understood. The purpose of this study was to detect any correlation between patient reported outcome measures (PROM) and clinical follow-up measurements. Patients with internal derangement of the TMJ treated with arthroscopic lysis and lavage 2014-2019 were consented for review of medical records and a follow-up PROM-questionnaire.

Re-examining the pathobiological basis of gait dysfunction in Parkinson's disease.

Parkinson's disease (PD) is a significant source of morbidity, especially with an aging population. Gait problems, particularly freezing of gait (FOG), remain a persistent issue, causing falls and reduced quality of life without consistent responses to therapies. PD and related symptoms have classically been attributed to dopamine deficiency secondary to substantia nigra degeneration from Lewy body (LB) and Lewy neurite (LN) infiltration.

Evaluating osteopontin as a biomarker of obesity related complications before and after metabolic and bariatric surgery: A systematic review and meta-analysis.

Background/objectives: Obesity is a major public health concern, significantly elevating the risk of developing comorbid conditions such as type 2 diabetes mellitus and cardio-vascular diseases, while also shortening life expectancy. Currently, metabolic and bariatric surgery (MBS) is one of the most effective long-term interventions for achieving substantial weight loss, alongside notable improvements in overall quality of life. However, evidence suggests that these procedures may negatively affect bone health, leading to an increased risk of fractures.

Symptom Clusters in Patients with Brain Tumors: A Systematic Review.

Objectives: To identify composition, predictors, outcomes and stability of symptom clusters in brain tumor patients and to examine assessment tools and statistical methods.

Methods: The PubMed, Web of Science, Embase, CINAHL, and Cochrane Library databases were systematically searched. Two reviewers independently screened the titles, abstracts and full texts.

The Impact of Loneliness on Late-Life Depression and Anxiety During the COVID-19 Pandemic.

Objective: This study investigates the association of loneliness during the COVID-19 pandemic and the course of depressive, anxiety and sleep symptoms after psychological treatment in older adults.

Methods: During the first wave of the pandemic in 2020, we assessed additional, original data of 132 participants aged ≥60 years who had completed psychological treatment for late-life depression (LLD) in the context of a multicenter, randomized controlled trial (CBT-late). We measured loneliness using the UCLA Loneliness Scale.

Heterogeneous seafloor deposition of heavy microplastics in the North Pacific estimated over 65 years.

Marine plastic pollution has been a public concern for many decades; however, transport processes of heavy microplastics to the seafloor have long been overlooked given the difficulties in sampling and modeling. The distribution of heavy microplastic deposition on the seafloor in the North Pacific for 65 years since 1951, was estimated using a particle tracking model with 577,143,840 particles. The model revealed that 22 % of heavy microplastics were deposited over 100 km offshore from their release locations.

A qualitative exploration of illness-related experiences, emotions, and coping among adults with postural orthostatic tachycardia syndrome (POTS).

Postural orthostatic tachycardia syndrome (POTS) is a relatively common, burdensome condition of the autonomic nervous system characterized by orthostatic intolerance. This paper presents a subset of findings from a qualitative study investigating the lived experience and perspectives of adults with POTS. Twenty-nine individuals participated in a series of focus groups.

Human genetic variants in SLC39A8 impact uptake and steady-state metal levels within the cell.

The human () gene encodes a plasma membrane protein SLC39A8 (ZIP8) that mediates the specific uptake of the metals Cd, Mn, Zn, Fe, Co, and Se Pathogenic variants within are associated with congenital disorder of glycosylation type 2 (CDG type II) or Leigh-like syndrome. However, numerous mutations of uncertain significance are also linked to different conditions or benign traits. Our study characterized 21 variants and measured their impact on protein localization and intracellular levels of Cd, Zn, and Mn We identified four variants that disrupt protein expression, five variants with high retention in the endoplasmic reticulum, and 12 variants with localization to the plasma membrane.

Cryo-EM structures reveal the H/citrate symport mechanism of INDY.

I'm Not Dead Yet (INDY) functions as a transporter for citrate, a key metabolite in the citric acid cycle, across the plasma membrane. Partial deficiency of INDY extends lifespan, akin to the effects of caloric restriction. In this work, we use cryo-electron microscopy to determine structures of INDY in the presence and absence of citrate and in complex with the well-known inhibitor 4,4'-diisothiocyano-2,2'-disulfonic acid stilbene (DIDS) at resolutions ranging from 2.

The Small Cycloamylose (CA15) Synthesizing Properties of 4-α-Glucanotransferase from Hyperthermophilic Archaeon with Its Distinct Disproportionation Activity.

4-α-Glucanotransferase (4-α-GTase, EC 2.4.1.