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C4d deposits on the surface of RBCs in trauma patients and interferes with their function.
Crit Care Med
May 2014
1Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. 2Department of Biomedical Engineering, Tulane University, New Orleans, LA. 3Institute of Surgical Research, San Antonio, TX.
Objective: Complement system is activated in patients with trauma. Although complement activation is presumed to contribute to organ damage and constitutional symptoms, little is known about the involved mechanisms. Because complement components may deposit on RBCs, we asked whether complement deposits on the surface of RBC in trauma and whether such deposition alters RBC function.
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