Left atrial to coronary sinus shunting in more advanced heart failure with preserved ejection fraction.

Aims: Inter-atrial shunt device therapy has shown mixed results in clinical trials, with clinical 'non-responders' typically showing features of more advanced heart failure. We aimed to analyse the haemodynamic and clinical response of a novel left atrial to coronary sinus (LA-CS) shunt device in patients with higher natriuretic peptide (NP) levels, a marker of disease severity.

Methods And Results: An analysis population (n = 95) of patients from the ALT-FLOW early feasibility study with left ventricular ejection fraction >40% and 1-year follow up was analysed.

Stigma by association revealed in a survey conducted among UNAFAM members.

Background: Stigma by association (also known as secondary, family, or courtesy stigma) adds to public stigma and self-stigma. First described by Erwin Goffman in 1963, it affects those close to stigmatized individuals, particularly people with mental health conditions. King et al.

Poor agreement between biopsies and endoscopic submucosal dissection specimens of Esophageal and Gastric Epithelial Lesions in a western setting.

Background: Endoscopic forceps biopsy is the primary method for obtaining mucosal tissues, but can lead to false negatives.

Aims: To assess the agreement between endoscopic biopsies and submucosal dissection specimens in esophageal and gastric epithelial lesions and to identify factors associated.

Methods: Cross-sectional study using data from the Spanish national multicenter endoscopic submucosal dissection register.

Vaccines and the risk of Guillain-Barré syndrome: A French pharmacovigilance analysis.

Aims: Guillain-Barré syndrome (GBS) is a rare autoimmune-mediated disease that can occur in a post-vaccination context. During the vaccination surveillance program of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines, reports of GBS as a possible adverse effect (AE) of SARS-CoV-2 vaccines have been reported. Our aim was to describe post-vaccine reports of GBS whatever the vaccine used.

Brain health PRO/Santé cerveau PRO: The development of a web-based program for dementia literacy and risk factor reduction.

Background: Online educational programs focused on ways to improve brain health could increase participant literacy, empowerment, and engagement in activities that support personal brain health, potentially reducing dementia risk.

Objectives: Our goal was to develop an evidence-based online educational program with a focus on risk and protective factors for dementia. Here we present the rationale and features of the program and include results from a pilot study that assessed usability and acceptability.

Recreational nitrous oxide use in France in 2022: Results from a nationwide representative sample of adults.

Introduction: The increasing heavy and sustained use of nitrous oxide (NO) for recreational purposes in several countries is a growing public health issue, as it can cause neuropathy and other harms. Documenting recreational NO use prevalence and characteristics of people who use the drug in the general population is essential.

Methods: Between 2 March and 9 July 2022, we conducted a nationwide survey of a random sample of adults in France to estimate the prevalence of NO awareness and reported use.

Comparative analysis of lipid profiles and antioxidant potential of fruit oils from Tunisia and Canada: influence of extraction methods.

This study investigated the lipid profiles and free radical scavenging potential of fruit oils from Tunisia and Canada, utilizing three extraction methods: single screw, twin screw, and solvent extraction. Significant differences ( < 0.05) were found in the concentrations of essential fatty acids, including petroselinic, linoleic, oleic, and palmitic acids, between oils from the two regions.

Managing Patients with Head and Neck Cancer and Advanced Age or Comorbidities.

The dominant treatment paradigm for locoregionally advanced head and neck squamous cell carcinoma (HNSCC) involves postoperative or definitive radiotherapy with concurrent cisplatin chemotherapy. Despite years of research investigating de-intensified treatment, cisplatin-based chemoradiotherapy remains the standard, yet it is associated with significant acute and chronic toxicity. However, due to shared risk factors, such as advanced age, and tobacco and alcohol use, patients with HNSCC frequently have comorbid illnesses that impact treatment tolerability, adding complexity to treatment-related decision-making.

Levels and determinants of person-centred maternity care among women living in urban informal settlements: evidence from client exit surveys in Nairobi, Lusaka and Ouagadougou.

Background: Sub-Saharan Africa's rapid urbanisation has led to the sprawling of urban informal settlements. The urban poorest women are more likely to experience worse health outcomes and poor treatment during childbirth. This study measures levels of person-centred maternity care (PCMC) and identifies determinants of PCMC among women living in urban informal settlements in Nairobi, Lusaka and Ouagadougou.

Levels of physical activity in a large international cohort of patients with systemic lupus erythematosus.

Introduction: Physical activity (PA) holds a pivotal role in the improvement of mental health or depressive symptoms, as well as in the prevention of cardiovascular diseases (CVDs). Patients with SLE are exposed to an increased risk of CVDs and suffer from deteriorated quality of life compared with the general population. The aim of this study was to assess PA level and characteristics in a large international cohort of patients with SLE.

High density lipoproteins and COVID-19: preparing the next pandemic.

High-density lipoproteins (HDLs) are heterogeneous particles with pleiotropic functions including anti-inflammatory and anti-infectious effects. In clinical studies, lower HDL-associated cholesterol (HDL-C) concentration has been associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, severity and mortality. A reduction in the number of HDL particles, particularly small ones has been observed with alterations in their protein and lipid composition impairing their functions.

Diseases associated with anti-centromere protein F (anti-CENP-F) antibodies: insights from a large cohort study.

Introduction: Antinuclear antibodies (ANA) exhibit diverse specificities and are crucial biomarkers in autoimmune disease assessment. Among ANA, anti-centromere protein-F (CENP-F) antibodies have garnered interest due to their association with malignancies. This study aims to characterize the clinical and biological profiles of a large cohort of anti-CENP-F positive patients and evaluate associated diagnoses.

In Vitro Inhibition of Voltage-Dependent Sodium Currents by the Antifungal Drug Amorolfine.

Voltage-gated sodium (Nav) channels are critical for electrical signaling, and their pharmacological modulation can be leveraged for the development of therapeutic agents targeting various disorders. The local anesthetic (LA) site on Nav channels is particularly important, as it is a common target for many clinically used inhibitors, including anticonvulsants and antiarrhythmics. Our goal was to identify novel Nav channel inhibitors by leveraging physicochemical criteria, focusing on potential LA site binding candidates.

Designing the next generation of clinical trials in intermediate AMD- a consensus driven, pragmatic, proof of concept early intervention study.

A greater understanding of the pathophysiology of AMD has yielded potential therapeutic strategies for slowing vision loss. Structural imaging biomarkers and novel functional outcomes, both under intensive study as surrogate endpoints in AMD clinical trials, are new granular tools needed to assess disease progression and follow response to therapy. These advances have created, for the first time, the possibility to intervene early in AMD, and to measure success in a time frame feasible for clinical trials.

Alternative to the cervical approach for total temporomandibular joint prosthesis: a case series.

Purpose: New-generation total temporomandibular joint prostheses have demonstrated their efficacy and low morbidity. However, their implantation requires a dual external approach, which can result in significant aesthetic and functional sequelae. The authors have therefore developed an alternative technique that avoids the cervical route.

Early detection of Parkinson's disease: Retinal functional impairments as potential biomarkers.

Background: Parkinson's disease is typically diagnosed after substantial neurodegeneration despite early non-motor symptoms manifesting decades earlier. These changes offer a promising avenue for diagnostic exploration, especially within the eye, which has been proposed as a "window to the brain."

Objective: The aim was to identify biomarkers by validating the use of electroretinography, a non-invasive technique, to detect early retinal function anomalies reflecting central dysfunction.

[The medical biologist "under the microscope" : analysis of digital images depicting laboratory medicine].

In France, the practice of laboratory medicine has, over the past ten years or so, met with a certain amount of disenchantment from medical students. Despite its intricacy and importance to healthcare, the world of the clinical laboratory lacks visibility in medical studies. While other phenomena can explain this disenchantment, our belief in the importance of promoting greater visibility of laboratory medicine in medical studies led us to examine for this article the images and symbols associated with the profession, based on a semiotic analysis.

Tentative renderings: Describing local data infrastructures that support the implementation and evaluation of national evaluation Initiatives.

Objective: Data journeys are a way to describe and interrogate "the life of data" (Bates et al 2010). Thus far, they have been used to clarify the mobile nature of data by visualizing the pathways made by handling and moving data. We wanted to use the data journeys method (Eleftheriou et al.

Noncoding RNAs as Tools for Advancing Translational Biology in Plants.

Noncoding RNAs (ncRNAs), once considered the "dark matter" of the genome, have emerged as critical regulators of gene expression in plants. Research initially focused on model organisms has laid the groundwork for harnessing the potential of ncRNAs in agriculture, particularly for crop protection, improvement and modulation. This review explores the role of long and small ncRNAs in plant biology, highlighting their application as powerful tools in agricultural biotechnology.

Hepatitis B core-related antigen rapid diagnostic test for point-of-care identification of women at high risk of hepatitis B vertical transmission: a multicountry diagnostic accuracy study.

Background: Timely administration of the hepatitis B virus (HBV) birth dose vaccine, along with identifying high-risk pregnant individuals for antiviral prophylaxis, is essential for the global elimination of vertical transmission of HBV. However, in resource-limited settings, access to HBV DNA testing is scarce, and accurate rapid tests for HBeAg are lacking. We aimed to assess the diagnostic performance of a newly developed hepatitis B core-related antigen (HBcrAg) rapid diagnostic test (RDT) to identify women who are HBsAg-positive and eligible for antiviral prophylaxis.

Contextual factors influencing basketball training and competition demands: a systematic review.

This systematic review described the effects of contextual factors on basketball training and competition demands. A comprehensive search and process led to the inclusion of 28 articles representing 646 basketball players. Fourteen contextual factors were identified.

Immunohistochemical expression of testin protein in testicular tumours in dogs.

Testin (TES), a protein localised in the cytoplasm and belonging to the LIM family of proteins, is part of the cytoskeleton localised along stress fibres and recruited to focal adhesions. It is considered a tumour suppressor protein in humans and decreased TES expression has been shown to increase cell motility and decrease cell-cell contact. In veterinary medicine, TES has only been studied in rat testes and, more recently, also in canine testes.

Immune checkpoint inhibition in metastatic or non-resectable melanoma after failure of adjuvant anti-PD-1 treatment. A EUMelaReg real-world evidence study.

Background: Adjuvant immune checkpoint inhibition (ICI) with anti-PD-1 antibodies in high-risk resected melanoma has been shown to improve recurrence-free survival. It is unclear whether prior adjuvant anti-PD-1 therapy is associated with altered response to subsequent ICI treatment in the metastatic setting.

Methods: Using data from the European Melanoma Registry (EUMelaReg), we analyzed the efficiency of first-line (1L) ICI in non-resectable or metastatic melanoma after failure from prior adjuvant anti-PD-1 treatment.