Occupational safety of healthcare workers in the terms of the Covid-19 pandemic as the public health aspect.

Objective: Aim: To assess the level of occupational safety, health and hygiene of healthcare workers in the terms of the COVID-19 pandemic..

Patients And Methods: Materials and Methods: bibliosemantic, bibliographic, analytical, statistical methods as well as a systemic approach have been used in the research.

The modern view of the use of extracorporeal detoxification in the treatment of drug poisoning (overdose).

Objective: Aim: To analyze the results of the application of extracorporeal detoxification methods in the treatment of drug poisoning and their complications..

Patients And Methods: Materials and Methods: The studied data of 129 patients aged 18-46 years with severe drug poisoning treated at the Kyiv toxicological center in 2010-2020.

An oral developmental toxicity study of generic pesticide pinoxaden in rabbits.

The safety assessment of pinoxaden by the Joint Meeting on Pesticide Residues (JMPR) established a NOAEL of 30 mg/kg bw/day for maternal and embryo/fetal toxicity from a rabbit developmental toxicity study. However, the Pesticide Peer Review Expert meeting (EFSA) lowered the NOAEL to 10 mg/kg bw/day due to observed diaphragm malformations in one developmental toxicity study in rabbits, proposing a classification for developmental effects as Category 2 R63 or H361d. Both JMPR and EFSA set the Acceptable Daily Intake (ADI) at 0.

The environmental health impacts of Russia's war on Ukraine.

Background: Russia's invasion of Ukraine in February 2022 ignited the largest armed conflict in Europe since World War II. Ukrainian government agencies, civil society organizations, and international agencies have gathered an unprecedented amount of data about the impact of war on the environment, which is often the silent victim of war. We review these data and highlight the limitations of international governance for protection of the environment during time of war.

AGE AND GENDER-SPECIFIC FEATURES OF CYTOGENETIC CHANGES IN BUCCAL EPITHELIUM IN INDIVIDUALS RESIDING IN THE «SICK BUILDING».

Objective: The aim: The study of cytomorphological and cytogenetic features of the buccal epithelium of residents of apartments who complained of unpleasant odors in their homes.

Patients And Methods: Materials and methods: The state of buccal epithelium in residents of multi-story buildings was studied. A total of 237 individuals were examined, 117 males and 120 females, aged from 6 to 81 years.

Combined reproductive and developmental toxicity study of pesticide abamectin on male and female Wistar Hannover rats.

Abamectin is a widely used pesticide and anthelmintic for humans and animals. Previous toxicological studies showed evidence of adverse effects on reproduction, but the findings were inconclusive. Abamectin is known to exhibit teratogenic activity, causing different malformations during developmental stages in rats and rabbits.

A battery of in silico models application for pesticides exerting reproductive health effects: Assessment of performance and prioritization of mechanistic studies.

Given the high attention to endocrine disrupting chemicals (EDC), there is an urgent need for the development of rapid and reliable approaches for the screening of large numbers of chemicals with respect to their endocrine disruption potential. This study aimed at the assessment of the correlation between the predicted results of a battery of in silico tools and the reported observed adverse effects from in vivo reproductive toxicity studies. We used VirtualToxLab (VTL) software and the EndocrineDisruptome (ED) online tool to evaluate the binding affinities to nuclear receptors of 17 pesticides, 7 of which were classified as reprotoxic substances under Regulation (EC) No 1272/2008 on the classification, labelling and packaging of substances and mixtures (CLP).

PSYCHOLOGICAL FACTORS OF STUDENTS' VITALITY DURING THE WAR IN UKRAINE.

Objective: The aim: A theoretical analysis of the problem of the hardiness of a person who suddenly found himself in extreme conditions and an empirical study of his individual and psychological factors that contribute to the strengthening of this personal characteristic and mobilize the internal reserve of student youth.

Patients And Methods: Materials and methods: The following psychodiagnostic methods were used in the empirical study: "Methodology for the diagnosis of hardiness" by S. Muddy, "Test for the diagnosis of properties of the nervous system" by Y.

ASSESSMENT OF THE CONSEQUENCES OF THE DETERIORATION OF THE EPIDEMIOLOGICAL SITUATION DURING HOSTILITIES.

Objective: The aim: Scientific substantiation of the methodology for predicting the consequences of the worsening of the epidemic situation on the territory of Ukraine during military operations for the timely adoption of measures for the medical protection of military personnel in conditions of biological contamination.

Patients And Methods: Materials and methods: Determination and generalization of the impact of biological contamination due to the use of biological weapons were carried out considering the main determinants of the epidemic process using the index and coefficient of medical protection. Applied methods of scientific research: epidemiological, system, and information approach.

USING OF CALCULATION MODELS OF THE PENETRATION OF SUBSTANCES THROUGH THE SKIN IN THE ASSESSMENT OF THE RISK OF DERMAL INFLUENCE OF PESTICIDES ON WORKERS.

Objective: The aim: Quantitative characterization of parameters of penetration of pesticides through the skin and assessment of the risk of their dermal exposure to workers using the basic provisions of diffusion theory and calculation models.

Patients And Methods: Materials and methods: The penetration coefficient was calculated using the Potts's and Guy's equation: logKp,m = -2,8 - 6,0×10-3MW + 0,74logKo/w (R2 = 0.67).

ANTIHYPOXIC ACTIVITY OF 2,6-DIMETHYLPYRIDINE-N-OXIDE.

Objective: The aim: To study the antihypoxic activity of 2,6-dimethylpyridine-N-oxide in mice using the various experimental models of acute hypoxia under orally or intraperitoneally administration.

Patients And Methods: Materials and methods: The studies were performed on male CD-1 (SPF) mice. The antihypoxic activity of 2,6-dimethylpyridine-N-oxide was studied in three experimental models of acute hypoxia - hypercapnic hypoxia or hypoxia in a closed space, hemic hypoxia and histotoxic hypoxia at orally administration at doses 0.

RESULTS OF RESEARCH OF PERSONAL HYGIENE PRODUCTS FOR SUITABILITY FOR SPECIAL PROCESSING IN ZONES OF CHEMICAL, RADIOACTIVE CONTAMINATION AND IN COMBAT CONDITIONS.

Objective: The aim: Research of personal hygiene products with detoxification properties by evaluating their formulation composition, emulsifying and complexing ability to heavy metal ions and radionuclides.

Patients And Methods: Materials and methods: The complex-forming ability of raw materials with heavy metal ions was determined in vitro, the content of heavy metals was determined by the method of atomic emission spectrometry with inductively coupled plasma (BS EN 13805:2014); determined the content of 137Cs, 232Th, 40K, 226Ra, 90Sr in washings from the surface of the skin of hands treated with personal hygiene products. The means were tested for compliance with the standard on scintillation spectrometers of gamma radiation energy «SEG-001» «AKP-S» and beta radiation (SEB-01-70); methods used: MI 12-04-099 and MI 12-05-099.

Dietary Choice Reshapes Metabolism in by Affecting Consumption of Macronutrients.

The precise regulation of metabolism and feeding behavior is important for preventing the development of metabolic diseases. Here we examine the effects on metabolism of dietary choice. These changes are predicted to be dependent on both the quantity and quality of the chosen diet.

Low-toxic herbicides Roundup and Atrazine disturb free radical processes in Daphnia in environmentally relevant concentrations.

The use of glyphosate-based Roundup and triazine herbicide Atrazine has increased markedly in last decades. Thus, it is important to evaluate toxic effects of these herbicides to non-targeted organisms such as zooplankton to understand their safety toward aquatic ecosystems. In the current study, we performed Daphnia toxicity tests based on lethality to identify LC that provides acute aquatic toxicity classification criteria.

Dietary Sucrose Determines Stress Resistance, Oxidative Damages, and Antioxidant Defense System in .

Varied nutritional interventions affect lifespan and metabolic health. Abundant experimental evidence indicates that the carbohydrate restriction in the diet induces changes to support long-lived phenotypes. Reactive oxygen species (ROS) are among the main mechanisms that mediate the effect of nutrient consumption on the aging process.

Herbicide Roundup shows toxic effects in nontarget organism Drosophila.

Glyphosate-based herbicide Roundup, as the most employed herbicide used for multiple purposes in agriculture, adversely affects nontarget organisms. We tested the effects of Roundup applied at larval and adult stages. Roundup caused developmental delay and increased larvae mortality.

Acute inhalation toxicity of aerosolized electrochemically generated solution of sodium hypochlorite.

Objective: The objective was to determine the inhalation toxicity of the electrochemically generated sodium hypochlorite solution after its single administration to laboratory animals in the form of a highly dispersed aerosol.

Materials And Methods: The study has been conducted according to the OECD Test Guideline №403 'Acute Inhalation Toxicity.' Laboratory animals were exposed to inhalation of an aerosol containing 1.

EFFECT OF 2,6-DIMETHYLPYRIDINE-N-OXIDE ON THE SEVERITY OF CYTOGENETIC EFFECTS INDUCED BY DIOXIDINE IN BONE MARROW CELLS OF MICE.

Objective - to study the ability of 2,6-dimethylpyridine-N-oxide to modify the cytogenetic effects in mouse bone marrow cells caused by the pro-oxidant mutagen Dioxidine. The cytogenetic activity and mutagen-modifying effect of the plant growth regulator 2,6-dimethylpyridine-N-oxide (Ivin) were studied by the method of accounting for chromosomal aberrations in the bone marrow cells of CD-1 mice (males) with a single joint exposure with Dioxidine. Ivin was administered single orally in the form of an aqueous solution at doses of 710, 71, and 0.

Aspirin as a Potential Geroprotector: Experimental Data and Clinical Evidence.

Aging is a biological process with effects at the molecular, cellular, tissue, organ, system, and organismal levels and is characterized by decline in physical function and higher risks of age-related diseases. The use of anti-aging drugs for disease prevention has become a high priority for science and is a new biomedicine trend. Geroprotectors are compounds which slow aging and increase lifespan of the organism in question.

[; INFLUENCE OF N-OXIDE-2,6-DIMETHYLPYRIDINE ON THE EXPRESSION OF CYTOGENETIC EFFECTS INDUCED BY CYCLOPHOSPHAMIDE IN MOUSE BONE MARROW CELL].

Objective - to study the ability of N-oxide-2,6-dimethylpyridine to modify the cytogenetic effects in mouse bone marrow cells caused by an alkylating antitumor cytostatic cyclophosphamide.; The cytogenetic activity and mutagen-modifying effect of the plant growth regulator N-oxide-2,6-dimethylpyridine (Ivin) were studied by the method of accounting for chromosomal aberrations in the bone marrow cells of CD-1 mice (males) with a single joint exposure to cyclophosphamide. In the first variant of the research, Ivin was administered single orally in the form of an aqueous solution at doses of 710, 71, 7.

"Emerging Technologies and Medical Countermeasures to Chemical, Biological, Radiological, and Nuclear (CBRN) Agents in East Ukraine".

Since 2014, Ukraine has been beset by an armed conflict with international and internal dimensions. The nature of this conflict is multidimensional, and disaster preparedness and response in this context must be as well. Health experts from Ukraine, the United States of America, United Kingdom, Czech Republic, and Norway convened for an educational event in Dnipro, East Ukraine on November 11-15, 2019.

Study of the lifestyle of economically active population of the chernivtsi region: the prevalence of risk factors among business entities in the market.

Objective: Introduction: To reduce the burden of non-communicable diseases (NCDs) and premature mortality, it is necessary to influence the risks of their occurrence at all stages of life. Economically active population, which can be more at risk, is required the special attention. The aim of the study is to investigate the prevalence for risk factors of major NCDs among the economically active population of the Chernivtsi region in the example of business entities in the market.

The problem of acute pesticide poisonings of agricultural workers in ukraine under the conditions of the new business patterns.

Objective: Introduction: Due to introduction of new forms of agriculture and transformation of the treatment and preventive service in recent years, there has been a false impression of a sharp decrease in the level of occupational morbidity among agricultural workers 30 % to 25 % in the structure of general occupational morbidity in the 80-90s down to 0.2-0.4 %.

Differences in classification for skin corrosion/irritation in EU and Ukraine: Case study of alternative (in vitro and in silico) methods application for classification of pesticide active ingredient imazamox.

In Ukraine Globally Harmonized System of classification of chemicals has not been implemented yet. In this article we analyze differences between GHS/CLP classification systems and Hygienic Classification of Pesticides by the Degree of Hazard currently in force in Ukraine in respect of approach and criteria for classification of effects on skin. As a case study, we conducted in silico modelling of herbicide imazamox using skin irritation/corrosion modules of ToxTree.