2 results match your criteria: "L. Boltzmann-Institute for Experimental Anaesthesiology and Research in Intensive Care Medicine[Affiliation]"

Classification of malignant hyperthermia-equivocal patients by 4-chloro-M-cresol.

Anesth Analg

July 1997

L. Boltzmann Institute for Experimental Anaesthesiology and Research in Intensive Care Medicine, and Department of Anaesthesiology and General Intensive Care B, University of Vienna, Austria.

Article Synopsis
  • The study focused on the effects of 4-chloro-m-cresol (4-CmC) on muscle contractions in malignant hyperthermia (MH) equivocal (MHE) cases to clarify diagnostic ambiguities.
  • In vitro contracture tests were conducted on 35 participants, revealing that MH susceptible (MHS) muscles reacted significantly stronger to certain concentrations of 4-CmC compared to MHE halothane sensitive (MHEh) and malignant hyperthermia normal (MHN) muscles.
  • The research indicates 4-CmC might help refine MHE diagnoses, but it’s too early to rely on it fully, as MHE individuals may still have underlying genetic issues that affect their reaction to MH.
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The amounts of halothane and isoflurane trapped after exposure for up to 3 h at 2 MAC in commonly used anaesthesia circuit tubing were quantitated by gas chromatography. The decontaminating effects of procedures such as flushing with oxygen, thermal disinfection and/or routine storage were assessed in a similar way. After halothane exposure, anaesthetic content was highest in silicone (398 +/- 55 mg 100 g-1).

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