electrochemical regeneration of active 1,4-NADH for enzymatic lactic acid formation concerted functions on Pt-modified TiO/Ti.

Nicotinamide adenine dinucleotide (NAD) and its reduced form (NADH) are key cofactors serving as essential hydrogen acceptors and donors to facilitate energy and material conversions under mild conditions. We demonstrate direct electrochemical conversion to achieve highly efficient regeneration of enzymatically active 1,4-NADH using a Pt-modified TiO catalyst grown directly on a Ti mesh electrode (Pt-TOT). Spectral analyses revealed that defects formed by the inclusion of Pt species in the lattice of TiO play a critical role in the regeneration process.