2 results match your criteria: "Kyushu University 3-1-1 Maidashi Higashi-ku Fukuoka[Affiliation]"
Novel strategy for activating gene expression through triplex DNA formation targeting epigenetically suppressed genes.
RSC Chem Biol
August 2024
Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University 1-1-1 Tsushima-naka Kita-ku Okayama 700-8530 Japan
Article Synopsis
- Triplex DNA formation is a promising technique for targeting genes, but has limitations in its original forming sequences.
- Researchers developed a new molecule, guanidino-dN, which effectively recognizes methylated CG base pairs, allowing for enhanced triplex DNA formation.
- This method successfully increased the expression of the RASSF1A gene in breast cancer cells, leading to suppressed cell growth and changes in gene expression related to cancer survival and apoptosis.
Functional modulation of human recombinant gamma-aminobutyric acid type A receptor by docosahexaenoic acid.
J Biol Chem
May 1998
Department of Physiology, Faculty of Medicine, Kyushu University 3-1-1 Maidashi Higashi-ku Fukuoka, 812-82, Japan.
Human gamma-aminobutyric acid type A (GABAA) receptors were expressed in the baculovirus/Sf-9 insect cell expression system using recombinant cDNA of alpha1beta2gamma2s subunits. The effect of unsaturated fatty acids on GABAA receptor complexes was investigated electrophysiologically using conventional whole cell recording under voltage clamp. Three distinct effects of docosahexaenoic acid (DHA) on the GABA responses were observed.
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