Safety assessment of IDCC 2201 used for product manufacturing in Korea.

Safety evaluation of probiotics has become increasingly important for human consumption in food industry. The aims of this study were to assess safety of IDCC 2201 through in vitro and in vivo tests. In results, this strain was found to be negative for hemolytic and β-glucuronidase activity.

PDK2 Deficiency Prevents Ovariectomy-Induced Bone Loss in Mice by Regulating the RANKL-NFATc1 Pathway During Osteoclastogenesis.

Estrogen deficiency leads to osteoporosis as a result of an imbalance in bone remodeling due to greater bone resorption. Estrogen deficiency increases the osteoclastic resorption of bone, and many of the FDA-approved therapies for osteoporosis are antiresorptive drugs that mainly act by reducing osteoclast activity. The mitochondrial enzyme pyruvate dehydrogenase kinase (PDK) is a critical regulator of aerobic glycolysis that exerts its effects by phosphorylating the pyruvate dehydrogenase complex (PDC), which is responsible for oxidative phosphorylation.

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms.

There has been a strong and urgent demand to diagnose community transmission-driven coronavirus disease 2019 (COVID-19) after it crossed borders. A large number of rapid and accurate tests and diagnoses are required at drive-through test stations, community clinics and hospitals. Isothermal amplification technology, such as loop-mediated isothermal amplification (LAMP) and recombinase polymerase amplification (RPA), provides excellent alternatives for resource limited test environments.

Size-dependent magnetic and magnetothermal properties of gadolinium silicide nanoparticles.

Gadolinium silicide (GdSi) nanoparticles are an interesting class of materials due to their high magnetization, low Curie temperature, low toxicity in biological environments and their multifunctional properties. We report the magnetic and magnetothermal properties of gadolinium silicide (GdSi) nanoparticles prepared by surfactant-assisted ball milling of arc melted bulk ingots of the compound. Using different milling times and speeds, a wide range of crystallite sizes (13-43 nm) could be produced and a reduction in Curie temperature ( ) from 340 K to 317 K was achieved, making these nanoparticles suitable for self-controlled magnetic hyperthermia applications.

Effects of Thin-Film Thickness on Sensing Properties of SnO₂-Based Gas Sensors for the Detection of H₂S Gas at ppm Levels.

SnO₂ thin-film gas sensors were easily created using the ion sputtering technique. The as-deposited SnO₂ thin films consist of a tetragonal SnO₂ phase and densely packed nanosized grains with diameters of approximately 20-80 nm, which are separated by microcracks. The as-deposited SnO₂ thin film is well crystallized, with a dense columnar nanostructure grown directly onto the alumina material and the Pt electrodes.

Analysis of CMOS Logic Inverter Based on Gate-All-Around Field-Effect Transistors with the Strained-Silicon Layer for Improving the Switching Performances.

In this paper, we adopt the vertical core-shell nanowire field-effect transistors based on the Silicon-germanium (SiGe)/strained-silicon (strained-Si) layer as a method to improve the performance of the CMOS logic inverter by using technology computer aided design simulation. The lattice constant mismatch between the core region and the shell region causes the global strain of the Si region of the shell, which in turn changes the Si parameters. This phenomenon effects on the improvement the electrical characteristics in the -type MOSFET (MOSFET).

The linkers in fluorene-labeled 2'-deoxyuridines affect fluorescence discriminating phenomena upon duplex formation.

Three fluorene-labeled 2'-deoxyuridines that differ in terms of their linkers-U (without linker), U (with ethynyl linker), and U (with diethynyl linker)-have been introduced at the central positions of oligodeoxynucleotides to examine the effects that their linkers have on the fluorescence emission properties upon duplex formation with fully matched and single-base-mismatched targets. Here, we describe the influence of the linkers on the emission behavior, the intramolecular electron transfer between the fluorene moiety and the uracil base after photoexcitation, and the structural stability upon duplex formation. The probe containing the U residue (with an ethynyl linker) and cytosine residues as flanking bases exhibited the greatest fluorescence turn-on selective behavior toward the perfectly matched target.

Protective effects of fermented rice extract on ulcerative colitis induced by dextran sodium sulfate in mice.

Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD), characterized by the gut mucosal ulceration. Growing evidence indicates that dysregulation of immune response to the commensal microbiota involves the pathogenesis of IBD. Previous studies have demonstrated the favorable probiotic effects of fermented rice extracts through triple fermentation with and (FRe).

Influence of E-beam irradiation on microbiological and physicochemical properties and fatty acid profile of frozen duck meat.

This study investigated the effect of different doses (0, 3, and 7 kGy) of e-beam on the microbiological and physicochemical qualities and the profile of fatty acids of the frozen duck meat (FDM). Electron beam at the dose of 3 kGy showed more than 2 log and 1 log cycles of reduction in the total bacterial (TAB) and coliform counts (TCC), respectively. The results indicated an increase in the TBARS values (1.

Two-dimensional square-grid iron(ii) coordination polymers showing anion-dependent spin crossover behavior.

Two Fe(ii)-based coordination polymers [Fe(tpmd)(NCS)]·5.5HO (1) and [Fe(tpmd)(NCSe)]·7HO (2) with the framework of square-grid type have been assembled from FeSO·7HO, ,,','-tetrakis(pyridin-4-yl)methanediamine (tpmd), and KNCS/KNCSe in methanol and characterized. By utilizing two pyridine groups of a tpmd ligand, 1 and 2 are formed in two-dimensional layered structures through coordination of octahedral iron(ii) ions with the tpmd to NCS/NCSe ligands in which they have a supramolecular isomorphous conformation.

A single nucleotide polymorphism rs12898 is associated with primary hepatic cancer in a Chinese population.

Background & Aims: Primary hepatic cancer (PHC) is a common malignant tumor and the third most frequent cause of cancer-related death worldwide. However, the molecular mechanisms underlying hepatic cancer remain unknown. is considered a biomarker of cancer as it can facilitate tumor progression.

First record of the land gastropod genus from South Korea (Helicarionoidea Bourguignat, 1877).

Habe, 1946 is a land snail genus, which is known so far from Japan and Taiwan. Individuals of this genus were collected from Gageodo Island, South Korea. This is the first record of the genus from this country.

Effect of Germinated Pigmented Rice "Superjami" on the Glucose Level, Antioxidant Defense System, and Bone Metabolism in Menopausal Rat Model.

Women experience physical, mental, and social changes during menopause. It is important to maintain a healthy diet for effective menopause management. The effect of germinated Superjami, a deep violet colored rice cultivar, on the body weight, glucose level, antioxidant defense system, and bone metabolism in a menopausal rat model was investigated.

Effects of chain extender on properties and foaming behavior of polypropylene foam.

Polypropylene (PP) foam offers superior thermal and mechanical properties and versatile applications. However, the linear structure of PP hinders the fabrication of a uniform and fine foam, owing to changes in the melt strength with variations in the temperature. The foamability of the material can be improved by fabricating modified PP by introducing long-chain branches by grafting and chain extension reactions, using glycidyl methacrylate (GMA) and adipic acid (AA).

Direct In Situ Growth of Centimeter-Scale Multi-Heterojunction MoS/WS/WSe Thin-Film Catalyst for Photo-Electrochemical Hydrogen Evolution.

To date, the in situ fabrication of the large-scale van der Waals multi-heterojunction transition metal dichalcogenides (multi-TMDs) is significantly challenging using conventional deposition methods. In this study, vertically stacked centimeter-scale multi-TMD (MoS/WS/WSe and MoS/WSe) thin films are successfully fabricated via sequential pulsed laser deposition (PLD), which is an in situ growth process. The fabricated MoS/WS/WSe thin film on p-type silicon (p-Si) substrate is designed to form multistaggered gaps (type-II band structure) with p-Si, and this film exhibits excellent spatial and thickness uniformity, which is verified by Raman spectroscopy.

Facile thermochemical conversion of FeOOH nanorods to ZnFeO nanorods for high-rate lithium storage.

We successfully prepared ZnFeO nanorods (ZFO-NRs) by a simple thermochemical reaction of FeOOH nanorods with Zn(NO) to use as an anode material in lithium-ion batteries. The FeOOH nanorod shape was well maintained after conversion into ZFO-NR with the formation of porous structures. The nanorod structure and porous morphology facilitate Li transport, improve the reaction rates owing to the larger contact area with the electrolyte, and reduce the mechanical stress during lithiation/delithiation.

Prognostic Implications of Door-to-Balloon Time and Onset-to-Door Time on Mortality in Patients With ST -Segment-Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention.

Background In patients with ST-segment-elevation myocardial infarction, timely reperfusion therapy with door-to-balloon (D2B) time <90 minutes is recommended by the current guidelines. However, whether further shortening of symptom onset-to-door (O2D) time or D2B time would enhance survival of patients with ST-segment-elevation myocardial infarction remains unclear. Therefore, the current study aimed to evaluate the prognostic impact of O2D or D2B time in patients with ST-segment-elevation myocardial infarction who underwent primary percutaneous coronary intervention.

Serum Metabolomic Profiling Identifies Key Metabolic Signatures Associated With Pathogenesis of Alcoholic Liver Disease in Humans.

Alcoholic liver disease (ALD) develops in a subset of heavy drinkers (HDs). The goals of our study were to (1) characterize the global serum metabolomic changes in well-characterized cohorts of controls (Cs), HDs, and those with alcoholic cirrhosis (AC); (2) identify metabolomic signatures as potential diagnostic markers, and (3) determine the trajectory of serum metabolites in response to alcohol abstinence. Serum metabolic profiling was performed in 22 Cs, 147 HDs, and 33 patients with AC using ultraperformance liquid chromatography-tandem mass spectrometry.

Combined effect of chitosan coating and modified atmosphere packaging on fresh-cut cucumber.

Fresh-cut cucumber was coated with different concentrations of edible chitosan solutions and packaged in air-, nitrogen-, and argon-based MA to preserve quality and extend shelf life. The effectiveness of individual and combined treatments on some quality parameters was examined at intervals during 12 days storage at a temperature of 5°C. The concentration of chitosan solutions significantly affected the performance of fresh-cut cucumber in MA packages.

Early perfusion and dopamine transporter imaging using F-FP-CIT PET/CT in patients with parkinsonism.

Combined use of F-N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl)nortropane (FP-CIT) for dopamine transporter imaging and F-fludeoxyglucose (FDG) for glucose metabolism shows good diagnostic performance for differential diagnosis of Parkinson disease (PD) and Parkinson plus syndrome (multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration, and dementia with Lewy bodies). A recent study showed that F-FP-CIT positron emission tomography (PET) with early perfusion imaging is useful for the differential diagnosis of PD and Parkinson plus syndrome with lower radiation exposure, time, and cost. In this review, we summarize the advantages of using F-FP-CIT PET for perfusion and dopamine transporter imaging, as well as clinical features useful for the differential diagnosis of PD and Parkinson plus syndrome.

Statistical study on the environmental effects on the natural variation of nutritional components in rice varieties.

This study was investigated to compare the natural variation of nutrients in rice variety by different environmental factors. Fifteen kinds of rices were used, which were cultivated in two locations for 2 years. All data were analyzed by the various statistical tools to identify the nutritional variations of nutrients.

Critical role of tristetraprolin and AU-rich element RNA-binding protein 1 in the suppression of cancer cell growth by globular adiponectin.

Adiponectin exhibits potent antitumor activities. Herein, we examined the molecular mechanisms underlying suppression of tumor growth by globular adiponectin (gAcrp). We demonstrated that gAcrp suppressed B-cell lymphoma 2 (Bcl-2) expression, an anti-apoptotic gene, by inducing its mRNA destabilization, which was accompanied with a decrease in cell viability and increased caspase-3 activity in hepatic cancer cells.

Correction: Indirect fabrication of versatile 3D microfluidic device by a rotating plate combined 3D printing system.

[This corrects the article DOI: 10.1039/C8RA08465C.].

Comparison of the quality of dried persimmon ( THUNB.) treated with medicinal plant extracts and food additives.

We evaluated the direct application of different extracts from plant-derived compounds at different ratios. The best effect was observed with the combination of 18.18% clove, 9.