69 results match your criteria: "Kyrle Disease"
An Unusual Case of Kyrle Disease.
Cureus
August 2024
Dermatology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune, IND.
Article Synopsis
- Kyrle disease is an acquired perforating disorder linked to conditions like type 2 diabetes and chronic kidney disease, characterized by skin lesions that show transepidermal elimination of dermal contents upon histopathological examination.
- In the reported case, the patient exhibited only hyperuricemia as an abnormal lab finding, with no typical associated conditions present, making the cause of the disease unclear.
- Treatment focused on addressing the underlying issues; however, the patient saw improvement with medications like acitretin, dapsone, and topical corticosteroids, highlighting the need for more research on factors like hyperuricemia in cases lacking classic associations.
A Case of Noonan Syndrome and Kyrle's Disease: Coincidence or Causality?
Acta Dermatovenerol Croat
March 2024
Marco Brusasco, MD, University of Parma, Via Gramsci 14, Parma, Italy;
Article Synopsis
- A 39-year-old woman with Noonan Syndrome and a RAF1 mutation presented with itchy lesions on her limbs that developed two months prior, characterized by multiple dome-shaped papules.
- Blood tests showed no abnormalities, but a skin biopsy revealed features consistent with Kyrle's disease, a type of perforating dermatosis.
- The patient was treated with narrowband UVB phototherapy, resulting in complete resolution of symptoms despite leaving residual atrophic scars.
Recalcitrant Reactive Perforating Collagenosis Successfully Treated with Dupilumab: A Case Report.
Clin Cosmet Investig Dermatol
June 2024
Department of Dermatology, Peking University People's Hospital, Beijing, People's Republic of China.
Reactive perforating collagenosis (RPC) is the most common form of the perforating dermatoses, which include RPC, elastosis perforans serpiginosa (EPS), perforating folliculitis (PF), and Kyrle disease (KD). In RPC, altered collagen of the dermis is extruded through the epidermis, which can be misdiagnosed as other skin diseases, such as vasculitis or prurigo nodularis. RPC is associated with a number of conditions, including diabetes mellitus, hepatitis, and renal failure, and thus the management of the coexisting diseases is important.
View Article and Find Full Text PDFA Case of Noonan Syndrome and Kyrle Disease: Casualty or Causality?
Acta Dermatovenerol Croat
December 2023
Marco Brusasco, MD, Dermatology Section Department of Medicine and Surgery, University of Parma, Via Gramsci, 14, 43126 Parma, Italy;
Article Synopsis
- A 39-year-old woman with Noonan Syndrome and RAF1 mutation presented with itchy skin lesions on her limbs, which were diagnosed as Kyrle disease (KD) after a detailed examination.
- KD is characterized by dome-shaped papules with a central keratotic plug and is often linked to systemic conditions such as chronic renal failure and diabetes, although this patient did not have these issues.
- Treatment involved narrowband UVB phototherapy, leading to complete resolution of symptoms, which highlights the importance of managing underlying health conditions in skin diseases like KD.
Kyrle disease: a case report and literature review.
Eur Rev Med Pharmacol Sci
November 2023
Department of Clinical and Experimental Medicine, Section of Dermatology, University of Messina, Messina, Italy.
Article Synopsis
- Perforating dermatoses are various skin disorders where skin tissue is eliminated through the epidermis, and they typically affect adults with other health issues like renal failure or diabetes.
- Kyrle disease is one type of perforating dermatosis, and this case report discusses a patient with Kyrle disease who also has chronic kidney disease, highlighting the need for proper treatment.
- The study emphasizes the importance of addressing itching and managing underlying health problems to improve the quality of life for patients suffering from Kyrle disease.
Acquired perforating dermatoses show increased levels of cutaneous advanced glycation end-products.
Clin Exp Dermatol
January 2022
Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy.
Article Synopsis
- Acquired perforating dermatoses (APDs) are skin conditions characterized by the elimination of skin materials, possibly linked to changes in glycation of dermal components.
- A study with 109 participants compared levels of advanced glycation end-products (AGEs) among patients with different skin conditions, including APDs, healthy controls, and those with atopic dermatitis.
- Results indicated that patients with APDs had significantly higher levels of skin AGEs, suggesting a potential role for AGEs in the mechanisms of skin elimination seen in these disorders.
New skin papules.
J Fam Pract
March 2021
Carolina University Brody School of Medicine, Greenville, NC, USA. Email:
Article Synopsis
- The patient's lesions were located in specific areas that provided clues to her condition.
- Her existing health issues also contributed to understanding her diagnosis.
- Together, the lesion locations and underlying conditions led to a clear diagnosis.
Dermatopathologic Signs of Systemic Disease I: Acquired Perforating Dermatosis and Kyrle Disease.
Skinmed
October 2021
Department of Pathology, Immunology and Laboratory Medicine, Rutgers - New Jersey Medical School, Newark, NJ.
sQuiz your knowledge: Hyperkeratotic plantar ulceration.
Eur J Dermatol
April 2020
Dermatology Department, University Hospital Fattouma Bourguiba, Monastir, Tunisia.
Dermoscopic pattern of Kyrle's disease.
An Bras Dermatol
May 2020
Department of Dermatology, Dokuz Eylul Universitesi, Balcova, Izmir, Turkey.
Article Synopsis
- - The clinical diagnosis of Kyrle's disease can be difficult because its lesions resemble those of other itchy skin conditions.
- - Despite the growing use of dermoscopy in medical practice, there is limited research on the dermoscopic features of Kyrle's disease, with only one previous report.
- - This text presents a case study that includes dermoscopic observations and diagnostic tips for accurately identifying Kyrle's disease, confirmed through histopathological analysis.
Kyrle disease associated with hidradenitis suppurativa successfully treated with tumour necrosis factor inhibition.
J Eur Acad Dermatol Venereol
August 2020
Dermatology Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.
The treatment of Kyrle's disease: a systematic review.
J Eur Acad Dermatol Venereol
July 2020
The Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
Article Synopsis
- * There are no established treatment guidelines for KD, making it difficult for healthcare providers to offer effective solutions, though a variety of treatments range from antibiotics to immunosuppressants and topical therapies.
- * A review of existing literature suggests that combination therapies, especially those with corticosteroids, are the most commonly used approaches, highlighting the need for more research and randomized controlled trials to improve treatment outcomes.
Dermoscopy of hyperkeratosis lenticularis perstans (Flegel disease).
J Dermatol
August 2019
Institute of Dermatology, "Santa Maria della Misericordia" University Hospital, Udine, Italy.
Kyrle's disease associated with HIV infection, diabetes, and chronic kidney disease.
Indian J Pathol Microbiol
November 2018
Postgraduate Program in Public Health; School of Medicine, Health Sciences Center, University of Fortaleza, Fortaleza, Ceara, Brazil.
Article Synopsis
- Kyrle's disease (KD) is a rare skin condition that involves the abnormal shedding of skin keratin and is linked to underlying health issues like diabetes, chronic kidney disease, and HIV.* -
- The article presents a case of a 51-year-old man who, after testing positive for HIV and beginning antiretroviral therapy, developed various skin lesions over two months.* -
- A biopsy confirmed KD, leading to treatment with keratolytic soap, which resulted in improvement of the skin lesions; the authors suggest that the combination of HIV, diabetes, and renal problems may have contributed to the skin condition.*
Kyrle's disease effectively treated with oral isotretinoin.
J Dermatolog Treat
September 2018
a Section of Dermatology, Department of Medicine , University of Verona, Verona , Italy.
Article Synopsis
- Kyrle's disease (KD) primarily affects middle-aged women, presenting as itchy, hyperkeratotic nodules and plaques mostly on the limbs and trunk.
- A case study of a 63-year-old woman showed that low-dose oral isotretinoin (20 mg/day) successfully treated her unresponsive lesions, leading to complete remission within four months.
- The treatment was well tolerated, with no disease recurrence observed during a nine-month follow-up, reinforcing isotretinoin's potential effectiveness for KD.
Kyrle's disease: a cutaneous manifestation of diabetes mellitus.
BMJ Case Rep
November 2017
Endocrinology, Diabetes and Bariatric Medicine, Narayana Health City, Bengaluru, Karnataka, India.
Acquired perforating dermatosis in a patient with chronic renal failure.
An Bras Dermatol
July 2017
Universidade Federal do Estado do Rio de Janeiro (UNIRIO) - Rio de Janeiro (RJ), Brazil.
Article Synopsis
- - Perforating dermatoses are skin diseases where dermal material is expelled through the epidermis, categorized into primary and secondary types.
- - The primary category includes four specific types focused on the materials eliminated: Kyrle disease, perforating reactive collagenosis, elastosis perforans serpiginosa, and perforating folliculitis.
- - The secondary type, or acquired perforating dermatosis, affects adults with systemic diseases, and the report details a case involving collagen and elastic fiber elimination in a patient with chronic renal failure.
Efficacy of topical tacrolimus for treating Kyrle's disease.
J Dermatol
May 2017
Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
Kyrle's Disease: A Rare Skin Manifestation of Diabetes Mellitus.
J Assoc Physicians India
July 2016
Professor, P.G. Department of Medicine, S.N. Medical College, Agra, Uttar Pradesh.
Article Synopsis
- Kyrle's disease is a rare skin condition marked by thickened patches and nodules, primarily found on the lower limbs.
- The cause of Kyrle's disease is not well understood but has been linked to various health issues like kidney disorders, diabetes, and certain infections.
- A case study presents a middle-aged woman with diabetes and related kidney problems undergoing hemodialysis who developed Kyrle's disease.
Dermoscopy of Kyrle disease.
J Am Acad Dermatol
September 2016
Dermatology Unit, Second University of Naples, Naples, Italy.
Successful treatment of Kyrle disease with narrowband ultraviolet B.
J Dermatol
June 2017
Department of Dermatology, Hirosaki University School of Medicine, Aomori, Japan.
Article Synopsis
- Acquired perforating disorders are rare skin issues linked to conditions like diabetes and chronic kidney failure, characterized by the skin expelling altered dermal material.
- A 69-year-old man sought dermatological help for skin lesions he believed were caused by parasites, which were ultimately diagnosed as Kyrle's disease after histopathological examination.
- This case highlights the unique connection between Kyrle's disease and delusions of parasitosis, suggesting that the itching associated with skin lesions may have triggered the patient's false beliefs while exacerbating his skin condition due to self-inflicted harm.
A Case of Infantile Kyrle-Flegel Disease in a 6-Year-Old Yemeni Girl.
Case Rep Dermatol
March 2016
Dermatology Department, University Hospital, Sana'a University, Sana'a, Yemen.
Article Synopsis
- Kyrle disease (KD) and Flegel disease (FD) are uncommon skin conditions involving the elimination of abnormal materials through the skin.
- A case study highlights a 6-year-old Yemeni girl with reddish-brown papules showing signs of both FD and histological evidence of KD.
- The diagnosis of KD-FD was made due to the combination of characteristics from both diseases, although the girl was otherwise healthy and had no family history of similar conditions.*