583 results match your criteria: "Kyoto City Hospital.[Affiliation]"
Hip-lumbar mobility loss affects quality of life in patients undergoing both lumbar fusion and total hip arthroplasty.
Bone Joint J
January 2025
Department of Orthopaedics, Kyoto City Hospital, Kyoto, Japan.
Aims: Overall sagittal flexion is restricted in patients who have undergone both lumbar fusion and total hip arthroplasty (THA). However, it is not evident to what extent this movement is restricted in these patients and how this influences quality of life (QoL). The purpose of this study was to determine the extent to which hip-lumbar mobility is decreased in these patients, and how this affects their QoL score.
View Article and Find Full Text PDFPrognostic value of a composite physiologic index developed by adding bronchial and hyperlucent volumes quantified via artificial intelligence technology.
Respir Res
December 2024
Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Background: The composite physiologic index (CPI) was developed to estimate the extent of interstitial lung disease (ILD) in idiopathic pulmonary fibrosis (IPF) patients based on pulmonary function tests (PFTs). The CALIPER-revised version of the CPI (CALIPER-CPI) was also developed to estimate the volume fraction of ILD measured by CALIPER, an automated quantitative CT postprocessing software. Recently, artificial intelligence-based quantitative CT image analysis software (AIQCT), which can be used to quantify the bronchial volume separately from the ILD volume, was developed and validated in IPF.
View Article and Find Full Text PDFImpact of neurovascular bundle preservation on biochemical recurrence after robot-assisted radical prostatectomy for high-risk prostate cancer.
World J Urol
December 2024
Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Purpose: To evaluate functional and oncological outcomes in patients who underwent unilateral or bilateral nerve-sparing (NS) robot-assisted radical prostatectomy (RARP) for high-risk prostate cancer.
Methods: The cohort comprised 2683 patients with clinical stage T1-4, N0M0 high-risk prostate cancer who underwent RARP in Japanese tertiary care centers from August 2011 to April 2023. High risk was defined using the European Association of Urology risk stratification criteria.
Corneal Endothelial Cell Morphology in Eyes With Down Syndrome.
Cornea
December 2024
Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Purpose: To explore the morphological characteristics of corneal endothelial cells in eyes with Down syndrome.
Methods: We conducted a comparative analysis of corneal endothelial cell density, coefficient of variation, hexagonal cell appearance rate, and corneal thickness using specular microscopy. Our study included 21 eyes of 11 patients with Down syndrome and 37 eyes of 19 control subjects.
Comparison of methotrexate dosing protocols for graft-versus-host disease prophylaxis after unrelated hematopoietic stem cell transplantation.
Cytotherapy
November 2024
Department of Hematology and Oncology, Kyoto University, Kyoto, Japan.
Background Aims: Methotrexate (MTX) is used as standard graft-versus-host disease (GVHD) prophylaxis in allogeneic hematopoietic stem cell transplantation. However, the optimal dosing regimen among the various MTX regimens available remains unclear.
Methods: We used the registration data of Kyoto Stem Cell Transplantation Group to compare six MTX dosing protocols in a multicenter retrospective analysis of 816 cases of unrelated bone marrow or peripheral blood stem cell transplantation.
Deep Learning Applied to Diffusion-weighted Imaging for Differentiating Malignant from Benign Breast Tumors without Lesion Segmentation.
Radiol Artif Intell
January 2025
From the Department of Fundamental Development for Advanced Low Invasive Diagnostic Imaging, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan (M.I.); Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan (M.I., M.K., M.H., Y.N.); A.I. System Research, Kyoto, Japan (R.M.); Kyoto University Faculty of Medicine, Kyoto, Japan (K.T., T.Y.); Department of Diagnostic Radiology, Kyoto City Hospital, Kyoto, Japan (A.M.); Department of Diagnostic Radiology, Kansai Electric Power Hospital, Osaka, Japan (M.H.); e-Growth, Kyoto, Japan (K.I.); and Department of Breast Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan (M.T.).
Article Synopsis
- - The study aimed to assess how well various AI models, specifically different types of convolutional neural networks (CNNs), could distinguish between benign and malignant breast tumors using diffusion-weighted imaging (DWI), and compared these results to evaluations made by radiologists.
- - Data was collected from 334 breast lesions scanned between May 2019 and March 2022, and results indicated that a small 2D CNN model outperformed a 3D CNN and matched or exceeded radiologists in diagnostic accuracy for identifying tumors.
- - The findings suggested that AI models, especially the small 2D CNN using data augmentation techniques, performed comparably to radiologists in both sensitivity and specificity, making them a viable tool in radiological
Optimal Duration of Consolidation Durvalumab Following Chemoradiotherapy in Stage III Non-Small Cell Lung Cancer: A Multi-institutional Retrospective Study.
Target Oncol
November 2024
Department of Radiation Oncology and Image-Applied Therapy, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Article Synopsis
- Durvalumab has shown potential to enhance survival in patients with locally advanced non-small cell lung cancer (NSCLC), but the optimal treatment duration is still unclear.
- This study analyzed 178 patients who received durvalumab after chemoradiotherapy, focusing on the ideal number of treatment cycles and examining survival rates.
- Results indicated that receiving 20 or more cycles significantly improved progression-free survival and overall survival, suggesting that durvalumab should be administered for more than 6 months for better outcomes.
A Case of Radiation Nephropathy Complicated by Tubulointerstitial Nephritis with Predominantly Lymphocyte and Plasma Cell Infiltration.
Intern Med
November 2024
Departments of Nephrology, National Hospital Organization Kyoto Medical Center, Japan.
A 64-year-old Japanese woman presented with gross hematuria and was diagnosed with stage IVB cervical cancer. Renal dysfunction was observed following chemoradiation therapy, and a renal biopsy revealed renal thrombotic microangiopathy (TMA) and tubulointerstitial nephritis (TIN), which are atypical features of radiation nephropathy. Contrast-enhanced computed tomography revealed wedge-shaped areas of high contrast, consistent with areas of high radiation dose in the kidneys, thus leading to the diagnosis of radiation nephropathy.
View Article and Find Full Text PDFEffect of studying abroad on catch-up vaccination in young adults: A study using the Japan Pretravel Consultation Registry.
J Infect Chemother
October 2024
Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan; AMR Clinical Reference Center, National Center for Global Health and Medicine, Tokyo, Japan.
Purpose: To investigate the effect of studying abroad on catch-up vaccination coverage for measles, rubella, mumps, varicella, and tetanus during the pretravel consultation among young adult travelers.
Methods: This retrospective cohort study analyzed data from the Japan Pretravel Consultation Registry (J-PRECOR) on individuals aged 18-21 years with childhood vaccination records. Propensity score weighting was used to estimate the average treatment effect on the proportion of participants receiving catch-up vaccination.
Characteristics and outcomes of salvage surgery after immune checkpoint inhibitor therapy for initially unresectable non-small cell lung cancer.
J Thorac Dis
September 2024
Department of Thoracic Surgery, Kyoto University, Kyoto, Japan.
Article Synopsis
- Immune checkpoint inhibitors (ICIs) have improved survival rates for advanced non-small cell lung cancer (NSCLC), but the effects of subsequent salvage surgery were previously unclear.
- This study analyzed data from patients who underwent salvage surgery after ICIs, focusing on characteristics, surgical outcomes, and survival rates from 2016 to 2022.
- Results showed that while the majority had good outcomes, those having surgery for primary tumors had better progression-free survival (PFS) compared to those with metastatic tumors, indicating potential benefits of selective salvage surgery post-ICI treatment.
Head-to-head comparison of Ga-FAPI-46 PET/CT, F-FDG PET/CT, and contrast-enhanced CT for the detection of various tumors.
Ann Nucl Med
October 2024
Department of Nuclear Medicine, University Clinic Essen, Hufelandstr. 55, 45147, Essen, Germany.
Objective: FAPI-PET/CT exhibits high tumor uptake and low background accumulation, enabling high-sensitivity tumor detection. We compared the diagnostic performance of Ga-FAPI-46 PET/CT plus contrast-enhanced CT (CE-CT), F-FDG PET/CT plus CE-CT, and standalone CE-CT in patients with various malignancies.
Methods: 232 patients underwent Ga-FAPI-46 PET/CT,F-FDG PET/CT, and CE-CT each within 4 weeks.
Mucosal cytokine expression associated with deep endoscopic mucosal healing in ulcerative colitis.
J Crohns Colitis
October 2024
Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kajiicho Hirokoji Kawaramachi Kamigyo-ku, Kyoto, Japan.
Background: Ulcerative colitis (UC) is a chronic inflammatory disease of unknown cause for which no curative treatments have been developed. Cytokines play an important role in the pathogenesis of UC, and therapies targeting specific cytokines have been successful in treating refractory UC. The purpose of this study was to measure mucosal cytokines in UC and identify those that contribute to non-relapsing mucosal healing diagnosed by endoscopy.
View Article and Find Full Text PDF[Progress in therapy with L-asparaginase].
Rinsho Ketsueki
October 2024
Department of Pediatrics, Kyoto City Hospital.
L-asparaginase is a key drug in the treatment of acute lymphocytic leukemia/lymphoblastic lymphoma and is currently used in treatment regimens for a wide range of age groups, including children, adolescents, young adults, and older adults. Discontinuation of L-asparaginase leads to worse survival outcomes. Strategies such as appropriate prevention and management of asparaginase-specific adverse events such as hypersensitivity reactions and optimizing administration by therapeutic drug monitoring are important to ensure completion of all asparaginase doses planned in each regimen.
View Article and Find Full Text PDFThe Impact of Spinopelvic and Hip Mobility on Passive Hip Flexion Range of Motion Assessment.
Arthroplast Today
October 2024
Department of Orthopaedic Surgery, Kyoto City Hospital, Kyoto, Japan.
Background: Measuring passive hip flexion range of motion (ROM) is challenging due to compensatory movements. Despite the interest in using functional lateral radiographs for assessing hip mobility, the relationship with passive hip flexion ROM remains unclear. This study aims to elucidate this relationship and clarify spinopelvic parameters and mobility factors influencing variations in passive and radiographic hip flexion ROM.
View Article and Find Full Text PDFMulticenter, open label, randomized controlled superiority trial for availability to reduce nocturnal urination frequency: The TOP-STAR study.
J Diabetes Investig
December 2024
Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Aim: Nocturia impairs the quality of life in patients with type 2 diabetes mellitus. Although sodium glucose co-transporter 2 inhibitors (SGLT2i) such as tofogliflozin increase urine volume, their impact on nocturia, in conjunction with dietary salt restriction, is less clear.
Materials And Methods: This multicenter, open-label, randomized, parallel-group trial included 80 subjects with type 2 diabetes and nocturia.
CYFRA 21-1 predicts efficacy of combined chemoimmunotherapy in patients with advanced non-small cell lung cancer: a prospective observational study.
Transl Lung Cancer Res
August 2024
Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Background: Tumor markers such as serum carcinoembryonic antigen (CEA) and cytokeratin fragment 19 (CYFRA 21-1) are utilized for assessing the effectiveness of chemotherapy in non-small cell lung cancer (NSCLC) patients. Yet, it remains uncertain whether these markers can reliably forecast responses to combined chemoimmunotherapy. Our study aimed to examine the significance and effectiveness of these markers in predicting responses among NSCLC patients undergoing combined chemoimmunotherapy.
View Article and Find Full Text PDFDevelopment of deep learning model for diagnosing muscle-invasive bladder cancer on MRI with vision transformer.
Heliyon
August 2024
Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, 54, Shogoin Kawahara-cho, Sakyo-Ku, Kyoto, 606-8507, Japan.
Article Synopsis
- A deep learning (DL) model using Vision Transformer (ViT) was created to automatically diagnose muscle-invasive bladder cancer (MIBC) from MRI scans.
- The study utilized data from multiple institutions, with a training dataset of 170 patients and a test dataset of 53 patients, comparing the ViT model's performance to conventional convolutional neural networks (CNNs) and radiologists' assessments.
- The results showed that the ViT model significantly outperformed CNNs in diagnostic accuracy, achieving an area under the curve (AUC) of 0.872, which is comparable to that of junior radiologists.
Dual Role of : Commensal Bacterium and Pathogen in Ocular Diseases.
Microorganisms
August 2024
Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto 602-0841, Japan.
Article Synopsis
- * A specific bacteria, which is common in the eye, decreases in abundance as we age and can behave as both an infectious agent and an immune trigger.
- * The review focuses on how this bacteria contributes to various eye inflammations, affecting diagnosis and treatment strategies.
Membranous Caval Obliteration and "Showerhead"-like Venous Obstruction in Budd-Chiari Syndrome.
Clin Gastroenterol Hepatol
August 2024
Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
A Retrospective Study of Pediatric Patients With Low- or Intermediate-Risk Acute Myeloid Leukemia Who Underwent Allogeneic Hematopoietic Cell Transplantation for the AML-05 Study Conducted by the Japanese Pediatric Leukemia/Lymphoma Study Group.
Transplant Cell Ther
November 2024
Central Japan Cord Blood Bank, Seto, Japan.
Article Synopsis
- - The AML-05 study focused on evaluating a risk-based treatment approach for children with acute myeloid leukemia (AML), determining that allogeneic hematopoietic cell transplantation (allo-HCT) wasn’t necessary for low- or intermediate-risk patients in their first complete remission.
- - A retrospective analysis identified key prognostic factors for survival in 79 pediatric patients who underwent allo-HCT, highlighting umbilical cord blood (UCB) as a particularly favorable donor source for low-risk patients, along with late relapse being advantageous for intermediate-risk patients.
- - The study found significant differences in three-year outcomes like overall survival (OS) and event-free survival (EFS) between low- and intermediate-risk groups, suggesting
Lower skeletal muscle density and airway structure on computed tomography in asthma.
Ann Allergy Asthma Immunol
December 2024
Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Background: Lower skeletal muscle density may reflect muscle adiposity and metabolic dysregulation that potentially impair disease control and lung function independent of high body mass index (BMI) in patients with asthma.
Objective: To investigate whether the lower density of pectoralis muscles (PMs) and erector spinae muscles (ESMs) on chest computed tomography was associated with airway structural changes in patients with asthma.
Methods: Consecutive patients with asthma and healthy controls undergoing chest computed tomography were retrospectively analyzed.
[Gastric-type adenocarcinoma consisting of signet-ring cell carcinoma and adenocarcinoma of the fundic gland type:a case report].
Nihon Shokakibyo Gakkai Zasshi
August 2024
Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine.
Article Synopsis
- - A 65-year-old man had endoscopic treatment for esophageal cancer and was later found to have a suspicious 12-mm flat lesion in his stomach during a surveillance endoscopy.
- - The lesion was examined with magnifying endoscopy and biopsy revealed atypical cells, leading to a diagnosis of a gastric-type neoplasm with low atypia.
- - Following further investigation, endoscopic submucosal dissection (ESD) led to a diagnosis of signet-ring cell carcinoma that transformed into adenocarcinoma of the fundic gland type, highlighting the complexity of his condition.
Management challenges and the role of adjuvant chemotherapy in remnant gastric cancer: an analysis of 313 patients from the KEGG multicenter observational study.
Gastric Cancer
November 2024
Department of Surgery, Kyoto University Hospital, 54 Shogoin-Kawahara-Cho, Sakyo-Ku, Kyoto, 606-8507, Japan.
Article Synopsis
- The study focuses on remnant gastric cancer (RGC) which is rare, examining clinical findings, postoperative data, and challenges in its management among 313 patients from 17 Japanese institutions.
- Results show that a significant portion of patients had early-stage RGC, but disease recurrence rates were notable, especially within the first few years post-surgery, with peritoneal recurrence being the most common.
- Adjuvant chemotherapy (AC) appeared to improve recurrence-free survival significantly, suggesting that AC might offer similar benefits as in primary gastric cancer despite some limitations in the study design.
Diagnostic Challenges in Invasive Mole With 18 F-FDG PET/CT.
Clin Nucl Med
December 2024
Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Article Synopsis
- A 34-year-old woman diagnosed with an invasive mole had an 18 F-FDG PET/CT scan to check for cancer spread.
- The scan showed no FDG uptake in the lungs despite CT indicating multiple lung metastases, but significant uptake was found in a pelvic lesion, hinting at ovarian metastasis.
- MRI revealed a ring-shaped enhancement consistent with a corpus luteum, which could be influenced by elevated human chorionic gonadotropin from the mole, emphasizing the need for careful interpretation of PET/CT results to avoid false positives.