95 results match your criteria: "Kyoritsu Women's University.[Affiliation]"

Multiple site inflammation and acute kidney injury in crush syndrome.

Front Pharmacol

August 2024

Department of General Medicine Education, School of Medicine, Keio University, Tokyo, Japan.

Article Synopsis
  • - Crush syndrome is a common consequence of earthquakes that can lead to acute kidney injury caused by muscle breakdown (rhabdomyolysis) and is worsened by systemic inflammatory response syndrome (SIRS).
  • - A study using mice with rhabdomyolysis showed high levels of inflammatory markers in both serum and the peritoneal cavity, where inflammation was more pronounced in the peritoneum.
  • - Administering a novel peptide that inhibits inflammation in the intraperitoneal cavity helped reduce muscle damage and kidney injury, suggesting that targeting inflammation in multiple areas could be beneficial for treatment.
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Refolding, Crystallization, and Crystal Structure Analysis of a Scavenger Receptor Cysteine-Rich Domain of Human Salivary Agglutinin Expressed in Escherichia coli.

Protein J

April 2024

Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan.

Article Synopsis
  • Scavenger receptors are a protein superfamily featuring a conserved domain called the scavenger receptor cysteine-rich structural domain (SRCRD), crucial for protein functionality.
  • A new method was developed for expressing a Type B SRCRD from human salivary agglutinin in Escherichia coli, which involves a refolding process to stabilize disulfide bonds, resulting in better protein solubility and quality.
  • The refolded SRCRD protein was successfully crystallized, demonstrating a high-resolution structure indicative of its integrity, and the findings could enhance future SRCRD protein expression and purification strategies.
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Article Synopsis
  • * A study reviewed literature on IDLA, revealing insulin absorption at affected sites was 27-94% lower than in normal areas, particularly at palpable IDLA sites.
  • * Four main mechanisms for decreased insulin absorption were identified: reduced blood flow, insulin binding to amyloid fibers, impaired diffusion, and physical handling of insulin. Future research is needed to explore these mechanisms in real-life conditions.
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Article Synopsis
  • This study focuses on the expression of glucose transporters (GLUTs) in non-small cell lung cancer (NSCLC) and their connection to patient outcomes and inflammation.
  • Researchers analyzed biopsy samples from 132 NSCLC patients, measuring the mRNA levels of various class I GLUTs and inflammation-related molecules.
  • Results showed that single expressions of SLC2A3 linked to worse prognosis and SLC2A4 linked to better outcomes in adenocarcinomas, while no such correlation was found in squamous cell carcinomas.
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In recent years, research in robotics and artificial intelligence (AI) has made rapid progress. It is expected that robots and AI will play a part in the field of nursing and their role might broaden in the future. However, there are areas of nursing practice that cannot or should not be entrusted to robots and AI, because nursing is a highly humane practice, and therefore, there would, perhaps, be some practices that should not be replicated by robots or AI.

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Crush syndrome induced by skeletal muscle compression causes fatal rhabdomyolysis-induced acute kidney injury (RIAKI) that requires intensive care, including hemodialysis. However, access to crucial medical supplies is highly limited while treating earthquake victims trapped under fallen buildings, lowering their chances of survival. Developing a compact, portable, and simple treatment method for RIAKI remains an important challenge.

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Some Japanese mothers do not follow package instructions of infant formula: a web-based analytical cross-sectional study.

BMC Nutr

November 2022

Laboratory of Public Health Nutrition, Department of Food Sciences and Nutrition, Kyoritsu Women's University, 2-2-1 Hitotsubashi, Chiyoda-ku, 101-8437, Tokyo, Japan.

Background: Not following the infant formula package instruction endangers infant health. Although infant formula misuse has been reported abroad, its incidence in Japan remains unknown. Furthermore, it is reasonable to assume that experience in childcare reduces the likelihood of making mistakes in using infant formula.

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This study aimed to examine the sleep habits in pairs of Japanese high school students and their mothers in the summer and autumn. Nineteen pairs of high school students and their mothers participated in this study. Wrist actigraphy, subjective sleep evaluations, and bedroom environmental measurements (temperature, humidity, and light) were performed for a duration of one week.

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Verification of the Usefulness of an Assessment and Risk Control Sheet that Promotes Management of Cancer Drug Therapy.

Front Pharmacol

February 2022

Department of Clinical Immunology and Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, Tokyo, Japan.

Proper management of adverse events is crucial for the safe and effective implementation of anticancer drug treatment. Showa University Hospital uses our interview sheet (assessment and risk control [ARC] sheet) for the accurate evaluation of adverse events. On the day of anticancer drug treatment, a nurse conducts a face-to-face interview.

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Feeding involves communication between mothers and infants and requires precise synchrony in a special triadic relationship with the food. It is deeply related to their intersubjectivity. This study compared the development of mother-infant intersubjectivity through interactional synchrony in feeding between 11 Japanese and 10 Scottish mother-infant dyads, observed at 6 and 9 months by video.

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Quercetin 3,5,7,3',4'-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1.

Commun Biol

February 2021

Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Sirtuin 1 (SIRT1), an NAD-dependent deacetylase, is a crucial regulator that produces multiple physiological benefits, such as the prevention of cancer and age-related diseases. SIRT1 is activated by sirtuin-activating compounds (STACs). Here, we report that quercetin 3,5,7,3',4'-pentamethyl ether (KPMF-8), a natural STAC from Thai black ginger Kaempferia parviflora, interacts with SIRT1 directly and stimulates SIRT1 activity by enhancing the binding affinity of SIRT1 with Ac-p53 peptide, a native substrate peptide without a fluorogenic moiety.

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Association between Work Environments and Stigma towards People with Schizophrenia among Mental Health Professionals in Japan.

Healthcare (Basel)

January 2021

Department of Psychiatric Nursing, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.

This study aimed to examine the association between control over practice in work environments and stigma toward people with schizophrenia among mental health professionals. We conducted secondary analyses on data from a self-administered questionnaire survey. The sample in the initial study included mental health professionals from two psychiatric hospitals, 56 psychiatric clinics, and community service agencies in Japan.

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This study aimed to examine the relationship between memory status of and factors related to patients in the intensive care unit (ICU) using a cross-sectional study design. Participants were adult patients who were admitted to the general ICUs for more than 48 hours. One week after ICU discharge, a survey on memory distortion was conducted.

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A genetically modified (GM) soybean kernel detection system using combination of DNA preparation from individual soybean kernels and event-specific real-time PCR was developed to simultaneously identify GM soybean events authorized for food after safety assessments in Japan. Over 100 kernels in the non-identity-preserved soybean samples imported from the United States of America (two U.S.

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Certified Nurse Specialists (CNS) are advanced practice nurses that often play a role in management. This study aims to investigate whether cooperation between CNSs in the position of Intensive Care Unit (ICU) head nurse and intensivists change the length of stay for ICU patients. A single centered retrospective cohort study design was followed.

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Hydrochloric acid (HCl)-treated wheat protein (HWP) is widely used in various products, including foods, cosmetics and shampoos. Recently, immediate hypersensitivity towards facial soap containing HWP has been reported. HCl treatment of protein causes hydrolysis not only of main-chain amide bonds (peptide-bond hydrolysis) but also of side-chain ones (deamidation).

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Drug-related work is one of the most difficult tasks for nurses. This may stem from the lack of knowledge of pharmacology as the minimum duration of the pharmacology course in basic nursing education is only 30 h (2 units). According to the Project to Collect Medical Near-miss/Adverse Event Information 2018 Annual Report of the Japan Council for Quality Health Care, 9.

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Objectives This study aimed to develop the Family Empowerment Scale for Parents with Toddlers (FES-P) and to examine its validity and reliability.Methods A draft version of the scale was prepared based on a literature review and interviews with experts. Next, we conducted a web-based structured questionnaire survey of 800 parents (400 men and 400 women) with children aged 1 to 3 years, across Japan, and then verified the validity and reliability of the FES-P.

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Objectives: This study evaluated the impact of the presence of a certified nurse specialist in critical care (CNS) as ICU head nurse in an open ICU on clinical outcomes.

Methods: The presence of a CNS as ICU head nurse was implemented in practice in April 2017. To evaluate the impact on patient outcomes before and after the implementation, patients were divided into two groups: before (April 2014 to March 2017; 1988 patients) and after (April 2017 to March 2019; 1664 patients).

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Starch starts to retrograde and form a crystalline structure immediately after gelatinization upon heating with water. The retrogradation rate is affected by the starch granule size, degree of polymerization, amylose/amylopectin ratio, starch concentration, water content, and storage temperature. Retrogradation of amylose occurs over a short term, while that of amylopectin occurs over a long term.

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Aim: To explore what factors may influence recovery knowledge and attitudes among professionals in mental health.

Methods: We utilized an existing dataset from a study that surveyed 331 subjects among 475 eligible professionals. We used data from 289 participants without missing values for the analyses (valid response rate = 60.

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Analytical survey of plasticizers used in about 500 polyvinyl chloride (PVC) toys in Japanese market was performed in 2014. The results obtained were compared with those obtained in 2009. Fifteen types of plasticizers including di (2-ethylhexyl) terephthalate (DEHTP) were detected.

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The present study aimed to investigate the effects of the combination of Marukome Nenrin miso, which has natriuretic effects, and Marukome MK-34-1 miso, which has potent angiotensin converting enzyme inhibitory effects, on blood pressure (BP) in humans. A total of 40 subjects aged 40-69 years with high-normal BP or stage I hypertension were randomly assigned to two groups: 1) the miso group (32 g 2:1 w/w Nenrin and MK-34-1 with 3.8 g salt/day) or 2) the control soy food group (14.

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We newly manufactured miso rich in angiotensin-converting enzyme (ACE) inhibitory activity (Marukome MK-34-1, shinki miso) and investigated its antihypertensive properties in rat models of genetic hypertension. ACE inhibitory activity was tenfold higher in shinki miso than in commercially available Marukome Nenrin miso (nenrin miso). The inhibitory activity of shinki miso was confined to <3 kDa fractions and was detected in several fractions with high polarity by C high-performance liquid chromatography.

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