Long-range intermolecular interaction between broken DNA fragments.

We analyzed the long-range intermolecular interaction between fragments of broken DNA. We considered two constituents of long-range intermolecular interaction. The first is a net electrostatic Coulomb interaction between charges, involved in a structure of opposite nucleotides, which we evaluate using Debye-Huckel theory.

Peculiarities of long-range interaction between the nucleotides after DNA damage.

In this work, the long-range interaction between the pairs of nucleotides situated on the opposite ends of a double broken DNA helix have been studied theoretically. The long-range energy was considered as a sum of electrodynamics Van der Waals and electrostatic Coulomb interactions. The most important region for the problem under consideration is about 5-15 A between the nucleotides.