Surgical management of oligometastatic recurrence in primary esophageal melanoma: a feasible approach in resource-limited settings.

Primary esophageal melanoma (PEM) is a rare and aggressive malignancy with limited treatment options. Due to its rarity, no standardized guidelines exist for managing oligometastatic recurrence, particularly in resource-limited settings. We present a case of a 60-year-old male with PEM who underwent esophagectomy followed by surgical resection of an adrenal metastasis.

Highly Optimized Simulation of Atomic Resolution Cell-Like Protein Environment.

Computational approaches can provide details of molecular mechanisms in a crowded environment inside cells. Protein docking predicts stable configurations of molecular complexes, which correspond to deep energy minima. Systematic docking approaches, such as those based on fast Fourier transform (FFT), also map the entire intermolecular energy landscape by determining the position and depth of the full spectrum of the energy minima.

The Diagnostic Role of the Platelet-to-Lymphocyte Ratio in Ovarian Cancer: A Systematic Review and Meta-Analysis.

Ovarian cancer is among the most lethal gynecologic malignancies, often diagnosed at advanced stages due to a lack of effective screening tools. Recent studies suggest that the platelet-to-lymphocyte ratio (PLR), an indicator of systemic inflammation, may serve as a potential biomarker for diagnosing and staging ovarian cancer. We conducted a systematic review and meta-analysis, adhering to PRISMA guidelines.

Biodegradation of Polyhydroxybutyrate, Polylactide, and Their Blends by Microorganisms, Including Antarctic Species: Insights from Weight Loss, XRD, and Thermal Studies.

This study explores the biodegradation of polyhydroxybutyrate (PHB), polylactide (PLA), and their blends by 11 bacterial species (including Antarctic strains) and 6 fungal species. Aeration significantly enhanced PHB degradation by mold fungi (, ) and bacteria (, ), while was most effective under non-aerated conditions. For PLA, degradation peaked under aeration with and .

Mental health of university students twenty months after the beginning of the full-scale Russian-Ukrainian war.

Background: Russia's full-scale military invasion of Ukraine on February 24, 2022 led to an increase of anxiety and depressive states, psychosomatic manifestations, and a tendency to abuse alcohol and psychoactive substances in the population. The aim of this paper is to examine the mental health burden among university students twenty months after war and to identify risk and protective factors for mental health problems.

Methods: A cross-sectional study was conducted among Ukrainian students in October 2023 (n = 1398).

In silico development of HASDI-G2 as a novel agent for selective recognition of the DNA sequence.

Genetic information, which is mostly encoded in the form of DNA sequence, is the basis of life. Its deviations are often the cause of the most deadly diseases such as cancer. Accordingly, the development of methods to control the transcription of certain DNA parts is an important direction of modern pharmacological and biological research.

Methods to assess on-farm biosecurity in Europe and beyond.

The aim of this study was to identify which biosecurity assessment methods (BAMs) are currently used in practice in animal farms. To address this, a structured questionnaire was developed to gather information such as the animal species, main objectives, type of enforcement, output generated and feedback of the result. In the context of the BETTER Cost Action project, country representatives identified in each of their countries which BAMs were used and completed an online survey.

The impact of ERN1 endoribonuclease activity inhibition on , , and genes expression in U87MG glioblastoma cells.

It is known that inhibition of the endoplasmic reticulum transmembrane signaling protein (ERN1) suppresses the glioblastoma cells proliferation. The present study aims to investigate the impact of inhibition of ERN1 endoribonuclease and protein kinase activities on the , , and gene expression in U87MG glioblastoma cells with an intent to reveal the role of ERN1 signaling in the regulation of expression of these genes. The U87MG glioblastoma cells with inhibited ERN1 endoribonuclease (dnrERN1) or both enzymatic activities of ERN1 (endoribonuclease and protein kinase; dnERN1) were used.

The ERN1 signaling pathway of unfolded protein controls the expression of EDEM1 and its hypoxic regulation in glioblastoma cells.

For the effective growth of malignant tumors, including glioblastoma, the necessary factors involve endoplasmic reticulum (ER) stress, hypoxia, and the availability of nutrients, particularly glucose. The ER degradation enhancing alpha-mannosidase like protein 1 (EDEM1) is involved in ER-associated degradation (ERAD) targeting misfolded glycoproteins for degradation in an N-glycan-independent manner. EDEM1 was also identified as a new modulator of insulin synthesis and secretion.

Enhancing energy efficiency in buildings using sawdust-based insulation in hot arid climates.

In the quest for sustainable construction solutions, this study explores the thermal insulation potential of sawdust as an eco-friendly material for building applications in hot-arid climates, with a focus on Iraq. The research evaluates the thermal behavior of sawdust when mixed with clay and glue, forming two different composite insulation materials. Laboratory experiments were conducted to measure thermal conductivity, with results compared against traditional insulators like Styrofoam.

Comparison of silver and gold nanoparticles green synthesis by Artemisia annua hairy root extracts.

The green synthesis of metal nanoparticles has garnered significant attention due to its simplicity, cost-effectiveness, and environmental sustainability. Gold nanoparticles (AuNPs) and silver nanoparticles (AgNPs) are widely employed across various industries, agriculture, and medicine owing to their unique physicochemical properties. This study explores the feasibility of synthesizing metal nanoparticles through green methods using ethanolic (70%) extracts from Artemisia annua hairy roots.

Unified resilience model using deep learning for assessing power system performance.

Energy resilience in renewable energy sources dissemination components such as batteries and inverters is crucial for achieving high operational fidelity. Resilience factors play a vital role in determining the performance of power systems, regardless of their operating environment and interruptions. This article introduces a Unified Resilience Model (URM) using Deep Learning (DL) to enhance power system performance.

General SIR model for visible and hidden epidemic dynamics.

To simulate hidden epidemic dynamics connected with asymptomatic and unregistered patients, a new general SIR model was proposed. For some cases, the analytical solutions of the set of 5 differential equations were found, which allow simplifying the parameter identification procedure. Two waves of the pertussis epidemic in England in 2023 and 2024 were simulated with the assumption of zero hidden cases.

Assessment of sarcopenia in young patients with inflammatory arthritis: a cross-sectional study.

Sarcopenia is a disease characterized by decreasing muscle mass and strength or performance. The prevalence of sarcopenia in rheumatic diseases has been evaluated in single diseases using various diagnostic approaches, generating conflicting data. The study aims to investigate sarcopenia prevalence in young adults with inflammatory arthritis (IA) and to detect factors associated with low muscle mass and strength.

Current priorities in research on metabolic-associated fatty liver disease based on the results of EASL - 2024.

Objective: Aim: To systematize and comprehensively analyze scientific sources and studies on metabolic-associated steatotic liver disease (MASLD) based on materials from the European Congress of the European Association for the Study of the Liver (EASL - 2024)..

Patients And Methods: Materials and Methods: This paper analyzes the current scientific research on the prevalence, pathogenesis, diagnostic methods, prognosis, and pharmacotherapy of MASLD presented at the EASL 2024 Congress.

The role of oxidative disorders in the pathogenesis of kidney damage in type 1 diabetes mellitus and diabetic nephropathy in children: xanthine oxidase as a trigger.

Objective: . Aim: This review aims to analyze scientific articles and publications on the role of oxidative stress and xanthine oxidase in the pathogenesis of type 1 diabetes mellitus and diabetic nephropathy in order to update the theories underlying its development and progression.

Patients And Methods: Materials and Methods: The literature analysis used peer-reviewed articles, reviews, and descriptions of experimental studies from 2021-2024.

Forensic medical and legal analysis of cases of improper performance of professional duties by medical employees, including incorrect prescription of medical products Anzhela B. Berzina, Alina O. Pletenetska BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE KEY WO RDS.

Objective: Aim: To conduct a forensic medical and legal analysis of cases of improper performance of professional duties by medical employees, including incorrect prescription of medical products..

Patients And Methods: Materials and Methods: The article is based on the analysis of defects in the performance of professional duties by medical employees, particularly according to data from commission forensic medical examinations, as well as an analysis of international and national legal acts and national judicial practices of Ukraine.

Peculiarities of psychophysical readiness formation in future law enforcement officers for their professional activities under martial law.

Objective: Aim: To investigate the impact of the improved Working Program of the academic subject "Special Physical Training" on the dynamics of indicators of cadets' physical and psycho-emotional state in their training process..

Patients And Methods: Materials and Methods: The research, which was conducted in 2023-2024, involved 167 male cadets of the 3rd and 4th training years of National Academy of Internal Affairs (Kyiv, Ukraine).

Comprehensive approach to the rehabilitation of professionals with high levels of psychophysical stress, pain syndromes and type 2 diabetes mellitus during the war Lidiia V. Butska1,2,3, Oksana O. Drevitska1,2,3, Sergei V. Dybkalyuk4, Valentyn O. Ryzhak 5 1TARAS SHEVCHENKO NATIONAL UNIVERSITY OF KYIV, KYIV, UKRAINE 2INTERREGIONAL ACADEMY OF PERSONNEL MANAGEMENT, KYIV, UKRAINE 3STATE INSTITUTION «KUNDIIEV INSTITUTE OF OCCUPATIONAL HEALTH OF THE NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE», KYIV, UKRAINE 4SHUPYK NATIONAL HEALTHCARE UNIVERSITY OF UKRAINE, KYIV, UKRAINE 5OPTIMUM MEDIA UKRAINE, KYIV, UKRAINE.

Objective: . Aim: To evaluate the effectiveness of a multilevel rehabilitation program integrating physiotherapy (PT), transcranial electrical stimulation (TES), and endonasal breathing of a singlet-oxygen mixture (EBSO) on pain syndromes (PS), quality of life (QL), and levels of depression in professionals with type 2 diabetes mellitus (T2DM) and high psychophysical stress.

Patients And Methods: Materials and Methods: Sixty professionals with high psychophysical stress were randomly divided into three groups (n=20 each).

Changes in mineral metabolism in blood and periodontium in animals with modelled peri-implantitis under the influence of a therapeutic and prophylactic complex.

Objective: Aim: To investigate the effectiveness of a therapeutic and prophylactic complex based on mineral metabolism markers in a peri-implantitis model under calcium deficiency conditions..

Patients And Methods: Materials and Methods: A peri-implantitis under calcium deficiency was modeled in experimental animals.

Morphological features of the dermis collagen fibers and regenerate filling the experimental skin wound cavity during its closure in different ways.

Objective: Aim: The purpose was to determine the morphological features of collagen fibers of the dermis and regenerate filling the cavity of the experimental skin wound during its closure by different methods..

Patients And Methods: Materials and Methods: The experimental study was conducted on 60 rats of the WAG population weighing 250-300 grams.

Engineering a Quality Management System for Academic Research: Navigating Challenges to Comply with the New Medical Device Regulations in Europe.

Purpose: The new Medical Device Regulations (MDR) in Europe represent unprecedented challenges for researchers in academic environments. Adherence to regulatory frameworks, like the Medical Device Directive (MDD), was mostly relevant for projects nearing commercialization. However, the MDR now extends its reach into the preliminary phases of pre-clinical research, imposing new challenges and necessitating compliance for any clinical investigation involving medical device safety or performance.

War in Ukraine vs. Motherhood: Mental health self-perceptions of relocated pregnant women and new mothers.

Background: The Russian military's carnal crimes render certain Ukrainian areas uninhabitable. As a result, a significant portion of the population is experiencing stress-related issues caused by hostilities and forced displacement. This research aimed to examine the self-assessed mental health of pregnant women and new mothers (PNM) who faced relocation.

Exploring the role of exosomes in diabetic neuropathy: From molecular mechanisms to therapeutic potential.

Diabetic neuropathy (DN) is a debilitating complication of diabetes mellitus (DM), characterized by progressive neuronal damage, sensory dysfunction, and impaired quality of life. Recent advances in exosome research have elucidated their crucial role in DN's pathogenesis, diagnosis, and treatment. Exosomes-nanoscale extracellular vesicles-function as vehicles for molecular cargo, including microRNAs (miRNAs), proteins, and lipids, which mediate intercellular communication and regulate key biological processes.