6 results match your criteria: "Kwansei Gakuin University 1[Affiliation]"

Optically active cofacial ABCD-Pt(II)-porphyrin dimer exhibits bright circularly polarized phosphorescence.

Chem Commun (Camb)

December 2024

Department of Applied Chemistry for Environment, School of Biological and Environmental Sciences, Kwansei Gakuin University 1 Gakuen Uegahara, Sanda, Hyogo 669-1330, Japan.

Article Synopsis
  • The synthesis of a chiral cofacial ABCD-Pt(II)-porphyrin dimer was successfully completed using a Pt-templated method followed by a Suzuki-Miyaura cross-coupling process.
  • The resulting enantiomers showcased bright red circularly polarized phosphorescence.
  • The phosphorescence had a high value of over 10 M cm, indicating strong optical properties.
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Article Synopsis
  • Raman spectroscopy was utilized to assess the effects of cytosine arabinoside (ara-C) on live neurons, which is important for selectively culturing neurons while excluding non-neuronal cells.
  • The study involved comparing Raman spectra from neurons exposed to different concentrations of ara-C (0, 5, and 25 µM) to determine how these levels impacted neurodevelopment.
  • Findings indicated that exposure to 5 µM ara-C did not significantly change neuronal characteristics, whereas 25 µM caused profound developmental alterations, emphasizing the effectiveness of Raman spectroscopy to detect minor physiological changes in neurons due to chemical exposure.
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Article Synopsis
  • - The self-assembly of d transition metal complexes like Pt(ii) and Pd(ii) is crucial for creating advanced materials used in optoelectronics and sensing, but understanding their electronic behaviors when excited is still unclear.
  • - This study compares the excited-state behavior of self-assembled Pt(ii) and Pd(ii) complexes, revealing that while both have similar structures, their thermal responses differ significantly.
  • - The Pt(ii) complex displays a dramatic thermochromic luminescence shift when heated, while the Pd(ii) complex shows increased luminescence efficiency when cooled, highlighting their contrasting properties.
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The decline in cellular iron is crucial for differentiation in keratinocytes.

Metallomics

April 2024

Department of Biomedical Sciences, Graduate School of Science and Technology, Kwansei Gakuin University. 1, Gakuen-Uegahara, Sanda 669-1330, Japan.

Iron is a vital metal for most biological functions in tissues, and its concentration is exquisitely regulated at the cellular level. During the process of differentiation, keratinocytes in the epidermis undergo a noticeable reduction in iron content. Conversely, psoriatic lesions, characterized by disruptions in epidermal differentiation, frequently reveal an excessive accumulation of iron within keratinocytes that have undergone differentiation.

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We report the first example of a synthetic thiol-based compound that promotes oxidative protein folding upon 1-equivalent loading to the disulfide bonds in the client protein to afford the native form in over 70% yield. -Methylation is a central post-translational processing of proteins for regulating functions including chaperone activities. Despite the universally observed biochemical reactions in nature, -methylation has hardly been utilized in the design, functionalization, and switching of synthetic bioregulatory agents, particularly folding promotors.

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Here, surface-enhanced Raman scattering (SERS) and tip-enhanced Raman scattering (TERS) were used to characterize the selective adsorption of N-substituted 4-[(NH-R)(phosphono)-S-methyl]phenylboronic acids on the surface of platinum nanoparticles (PtNPs) from an aqueous solution and from air. The nature of the interaction of the studied compounds with the PtNPs/H O and PtNPs/air interfaces was discussed and compared. For this purpose, 4-[(N-anilino)(phosphono)-S-methyl]phenylboronic acid (1-PBA-PA) and its two analogs (2-PBA-PA and bis{1-PBA-PA}) as well as the PtNPs were synthesized in surfactant/ion-free solution via a synthetic route that allows control of the size and morphology of the NPs.

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