1,338 results match your criteria: "KwanDong University College of Medicine[Affiliation]"

Article Synopsis
  • A study was conducted to evaluate the safety of COVID-19 treatments nirmatrelvir/ritonavir (NMVr) and molnupiravir (MOL) by comparing acute complications in treated versus untreated patients.
  • Data from nationwide databases were used to analyze results from over 700,000 NMVr users and over 150,000 MOL users, focusing on specific cardiac and neurological events.
  • The findings revealed that both NMVr and MOL users had a lower risk of certain serious side effects like atrial fibrillation and dysgeusia, suggesting these treatments may be effective in reducing acute complications linked to COVID-19.
View Article and Find Full Text PDF

Association Between Perceived Noise Pollution and Sleep Quality: Findings from the 2018 Community Health Survey.

Noise Health

September 2024

Department of Internal Medicine, International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, Republic of Korea.

Objectives: This study aimed to investigate the potential relationship between sleep quality and perceived noise.

Methods: A cross-sectional study involving 185,246 adults (81,854 men and 103,392 women) participating in the 2018 Korea Community Health Survey (KCHS) was conducted. Subjective sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI), while perceived noise pollutants were categorized into two groups: perceived noise pollution (n = 43,638) and perceived non-noise pollution (n = 141,608).

View Article and Find Full Text PDF

Association between Frailty and Asthma.

Medicina (Kaunas)

September 2024

Department of Internal Medicine, International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon 22711, Republic of Korea.

Article Synopsis
  • * Using the K-FRAIL scale, results showed that frailty was significantly higher (7.6%) in the asthma group compared to the non-asthma group (4.9%), particularly in areas like resistance, ambulation, and illness severity.
  • * After accounting for various factors, the study found that having asthma was associated with a 45% increased risk of frailty, indicating a potential connection that warrants further investigation.
View Article and Find Full Text PDF
Article Synopsis
  • - The study analyzes the oncologic outcomes for patients with biochemical recurrence (BCR) after radical prostatectomy (RP) who underwent either lymph node dissection (LND) or radiation therapy (RT) for positive lymph node recurrences detected by PET scans.
  • - It reviewed data from 2476 patients across 19 studies, finding that LND had higher rates of PSA and systemic progressions compared to RT, despite overall low mortality rates for both treatments.
  • - The authors emphasize the need for clearer trial designs in future research, particularly regarding the timing of PSMA PET scans and the use of concurrent systemic therapies alongside salvage treatments.
View Article and Find Full Text PDF

Modulation of Brain-derived Neurotrophic Factor Expression by Physical Exercise in Reserpine-induced Pain-depression Dyad in Mice.

Exp Neurobiol

August 2024

Department of Physiology and Medical Science, College of Medicine and Brain Research Institute, Chungnam National University, Daejeon 35015, Korea.

Article Synopsis
  • Chronic pain patients often experience depressive symptoms, and this study looked into how exercise affects brain-derived neurotrophic factor (BDNF) levels relating to pain and depression.
  • Mice were given reserpine (RSP) to induce pain and depression-like behaviors, then exercised on a rota-rod for seven days afterward, with various tests used to assess pain and depressive signs.
  • Results showed exercise lessened pain sensitivity and depression, while it also adjusted BDNF levels in affected areas of the nervous system, suggesting exercise could be a non-invasive treatment for conditions where pain and depression overlap.
View Article and Find Full Text PDF

Association of the COVID-19 lockdown with health risk behaviors in South Korean adolescents.

Medicine (Baltimore)

May 2024

Department of Internal Medicine, International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, Republic of Korea.

Article Synopsis
  • A study analyzed health risk behavior changes in South Korean adolescents (ages 12-18) using data from the Korea Youth Risk Behavior Survey, comparing pre-pandemic and during the COVID-19 pandemic periods.* -
  • Findings indicated significant decreases in behaviors such as alcohol consumption, substance use, sexual experiences, and instances of violence, as well as lower levels of stress, depression, and suicidal ideation during the pandemic.* -
  • The research suggests that the pandemic led to a notable reduction in various health risk behaviors among adolescents, highlighting a potential positive outcome of the lockdown measures.*
View Article and Find Full Text PDF

TERT mutations and aggressive histopathologic characteristics of radioiodine-refractory papillary thyroid cancer.

J Pathol Transl Med

November 2024

Department of Pathology, Gangnam Severance Hospital and Institute of Refractory Thyroid Cancer, Yonsei University College of Medicine, Seoul, Korea.

Article Synopsis
  • Radioiodine ablation is a common and effective treatment for papillary thyroid cancer (PTC), but some tumors become resistant, leading to poor outcomes and aggressive behavior.
  • This study compared genetic mutations (specifically BRAF V600E and TERT-promoter) and clinicopathological features between RI-refractory and RI-responsive PTC patients, analyzing tissue samples from both groups.
  • Findings revealed that RI-refractory tumors displayed more aggressive characteristics, such as higher instances of necrosis and metastasis, and were significantly associated with TERT mutations, alongside reduced expression of key proteins involved in thyroid function and tumor growth.
View Article and Find Full Text PDF

Purpose: We evaluated the feasibility, safety, and learning curve of extraperitoneal single-port robot-assisted radical prostatectomy (SP-RARP) and introduced innovative surgical techniques to maintain the instrument positions during the procedures.

Materials And Methods: A cohort of 100 patients underwent extraperitoneal SP-RARP at our institution from December 2021 to April 2023. The procedures were performed by an experienced urology surgeon utilizing two surgical techniques for dissecting the posterior aspect of the prostate-"changing instrument roles" and "using camera inversion"-to prevent positional shifts between the camera and instruments.

View Article and Find Full Text PDF

Acute kidney injury as a prognostic marker in severe fever with thrombocytopenia syndrome.

Sci Rep

September 2024

Department of Internal Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine, 156, Baengnyeong-Ro, Chuncheon-Si, Chuncheon, Gangwon-Do, 24289, Republic of Korea.

Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne illness with a notable morality risk that is becoming increasingly prevalent in East Asia (14-36%). Increasing evidence indicates a more direct role of the SFTS virus in renal impairment. However, few studies have explored the risk factors for and clinical outcomes of AKI in patients with SFTS.

View Article and Find Full Text PDF

Association between frailty and cognitive status among ambulating Korean elderly: An observational study.

Medicine (Baltimore)

August 2024

Department of Internal Medicine, International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, Republic of Korea.

We aimed to determine the association between frailty and cognitive status of the elderly population in Korea. We examined data from 9920 elders who participated in the 2020 Survey of Living Conditions and Welfare Needs of Korean Older Persons. Frailty was assessed using the Korean version of the Fatigue, Resistance, Ambulation, Illnesses, and Weight Loss scale.

View Article and Find Full Text PDF

Cerebrolysin Concentrate: Therapeutic Potential for Severe Oral Apraxia After Stroke: A Case Report.

Brain Neurorehabil

July 2024

Department of Rehabilitation Medicine, International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, Korea.

Cerebrolysin concentrate is a medication whose main active ingredient is brain-derived neurotrophic factor. It has been reported to help in the restoration of cognitive function and overall physical function after brain injuries. We present the case of a 72-year-old man with severe oral apraxia due to a left middle cerebral artery ischemic stroke involving the left insular cortex.

View Article and Find Full Text PDF

Medial Rectus Disinsertion for the Management of Large-Angle Sensory Esotropia.

Medicina (Kaunas)

July 2024

Department of Ophthalmology, Dongtan Sacred Heart Hospital, College of Medicine, Hallym University, Hwaseong-si 18450, Republic of Korea.

: The aim of the report is to report the outcomes of the medial rectus (MR) disinsertion procedure for the management of large-angle esotropia (ET) patients. : This is a retrospective case series of patients with large-angle ET who underwent an MR disinsertion procedure between March 2012 to April 2022. The procedure happened accidentally during muscle surgery.

View Article and Find Full Text PDF

Background: Minimally invasive radical hysterectomy (MIRH) has been increasingly adopted for its benefits of reduced blood loss and shorter hospital stays. This study aims to conduct a meta-analysis to compare the incidence of intraoperative urologic complications, including bladder and ureteral injuries, between MIRH and abdominal radical hysterectomy (ARH).

Method: The authors systematically searched PubMed, EMBASE, and the Cochrane Library for studies published up to April 2024.

View Article and Find Full Text PDF

Endotype and Phenotype Related Postoperative Effects of Bacterial Lysate in Chronic Rhinosinusitis.

Ann Otol Rhinol Laryngol

September 2024

Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University College of Medicine, Seoul National University Boramae Medical Center, Seoul, Republic of Korea.

Objectives: Chronic rhinosinusitis (CRS) endotypes have demonstrated clinical value in guiding treatment decisions. Bacterial lysates are immunomodulators that have shown beneficial effects in various respiratory inflammatory diseases. This study aimed to evaluate the effect of postoperative bacterial lysate therapy on different CRS endotypes.

View Article and Find Full Text PDF

Trends in alcohol use and alcoholic liver disease in South Korea: a nationwide cohort study.

BMC Public Health

July 2024

Department of Internal Medicine, Institute for Digestive Research, Digestive Disease Center, Soonchunhyang University College of Medicine, 59 Daesagwan-Ro, Yongsan-Gu, Seoul, 04401, Republic of Korea.

Background: There is a lack of national-level research on alcohol consumption and the epidemiology of alcoholic liver disease (ALD) in South Korea. This study aims to address the critical public health issue of ALD by focusing on its trends, incidence, and outcomes, using nationwide claims data.

Methods: Utilizing National Health Insurance Service data from 2011 to 2017, we calculated the population's overall drinking amount and the incidence of ALD based on ICD-10 diagnosis codes.

View Article and Find Full Text PDF

Background: Evaluating left ventricular diastolic function (LVDF) is crucial in echocardiography; however, the complexity and time demands of current guidelines challenge clinical use. This study aimed to develop an artificial intelligence (AI)-based framework for automatic LVDF assessment to reduce subjectivity and improve accuracy and outcome prediction.

Methods: We developed an AI-based LVDF assessment framework using a nationwide echocardiographic dataset from five tertiary hospitals.

View Article and Find Full Text PDF

Socioeconomic status and cardiovascular mortality in over 170,000 cancer survivors.

Eur Heart J Qual Care Clin Outcomes

July 2024

Division of Cardiology, Department of Internal Medicine, Seoul St. Mary's Hospital, Catholic Research Institute for Intractable Cardiovascular Disease, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.

Article Synopsis
  • This study explores the link between socioeconomic status (SES) and cardiovascular disease (CVD) mortality in cancer survivors, revealing that lower SES is associated with higher mortality rates.
  • Using a large database of cancer survivors, the research found that individuals in lower SES categories had progressively greater risks of CVD mortality, especially those with hypertension.
  • The results emphasize the need to consider SES as a critical risk factor for CVD in cancer survivors, particularly highlighting the combined impact of low SES and hypertension on mortality risks.
View Article and Find Full Text PDF

Choroidal venous overload in Vogt‒Koyanagi‒Harada disease.

Eye (Lond)

October 2024

Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Article Synopsis
  • * Signs of choroidal venous overload, such as perfusion delay and dilated veins, were significantly more common in VKH patients compared to controls, especially in the early stages of the disease.
  • * The findings suggest that angiographic signs of choroidal venous overload can be important indicators for assessing VKH disease progression and status.
View Article and Find Full Text PDF

The relationship between dementia caregivers and quality of life in South Korean populations.

Medicine (Baltimore)

June 2024

Internal Medicine, International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, Republic of Korea.

The purpose of this study was to assess the relationship between quality of life and dementia caregivers. The 2019 Korean Community Health Survey participants were assessed using the Patient Health Questionnaire-9, subjective cognitive decline (SCD) and SCD-related functional limitation, and EuroQol 5-dimension (EQ-5D). Sociodemographic and psychosocial variables were evaluated and compared between participants with dementia caregivers (n = 37,614) and non-dementia caregivers (n = 140,518).

View Article and Find Full Text PDF

Background: Knee osteoarthritis (OA) is a prevalent degenerative disease and causes disability, pain and imposes a substantial burden on patients. Conventional treatments for knee OA show limited effectiveness. Consequently, innovative treatments, such as radiofrequency ablation (RFA) and intra-articular mesenchymal stem cells (IA MSC), have gained attention for addressing these limitations.

View Article and Find Full Text PDF

Predictors associated with the rate of progression of nigrostriatal degeneration in Parkinson's disease.

J Neurol

August 2024

Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, 20 Eonjuro 63-gil, Gangnam-gu, Seoul, South Korea.

Background: Parkinson's disease (PD) manifests as a wide variety of clinical phenotypes and its progression varies greatly. However, the factors associated with different disease progression remain largely unknown.

Methods: In this retrospective cohort study, we enrolled 113 patients who underwent F-FP-CIT PET scan twice.

View Article and Find Full Text PDF

Background: Altering wrist biomechanics, Kienbock's disease leads to progressive carpal collapse that results in early arthritis and degenerative changes. By shifting the loading axis toward the radioscaphoid joint, scaphocapitate arthrodesis (SCA) has been reported as a salvage procedure effective in treating symptomatic patients with advanced Kienbock's disease. In this study, we aimed to evaluate the clinical and radiological outcomes of arthroscopic SCA in symptomatic patients with advanced stages of Kienbock's disease.

View Article and Find Full Text PDF

Background And Purpose: Olfactory dysfunction or dysautonomia is one of the earliest prodromal nonmotor symptoms of Parkinson's disease (PD). We aimed to investigate whether PD patients with dysautonomia and hyposmia at the de novo stage present different prognoses regarding PD dementia (PDD) conversion, motor complication development, and change in levodopa-equivalent doses (LED).

Methods: In this retrograde cohort study, we included 105 patients with newly diagnosed PD patients who underwent cross-cultural smell identification test (CC-SIT), autonomic function tests (AFT), and dopamine transporter (DAT) scan at the de novo stage.

View Article and Find Full Text PDF

We retrospectively evaluated the usefulness of an elevated glucose-to-lymphocyte ratio (GLR) as a sensitive prognostic biomarker of disease-specific survival in 338 patients who underwent surgical resection of pancreatic ductal adenocarcinoma (PDAC). The optimal GLR cutoff value was determined using the method of Contal and O'Quigley. Patient demographics, clinical information, and imaging data were analyzed to identify preoperative predictors of long-term survival outcomes.

View Article and Find Full Text PDF

Whole-genome sequences reveal zygotic composition in chimeric twins.

HGG Adv

July 2024

Research Center for Natural Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea. Electronic address:

While most dizygotic twins have a dichorionic placenta, rare cases of dizygotic twins with a monochorionic placenta have been reported. The monochorionic placenta in dizygotic twins allows in utero exchange of embryonic cells, resulting in chimerism in the twins. In practice, this chimerism is incidentally identified in mixed ABO blood types or in the presence of cells with a discordant sex chromosome.

View Article and Find Full Text PDF