The effect of mesoporous silica doped with silver nanoparticles on glass ionomer cements; physiochemical, mechanical and ion release analysis.

Background: The purpose of the study was to evaluate the effect of adding mesoporous silica with silver nanoparticles to conventional glass ionomer cements (GIC) on its, physical, chemical, mechanical properties and ion release analysis.

Methods: Synthesized mesoporous silica with silver nanoparticles were added in 1, 3 and 5% by weight to the liquid component of GIC forming three experimental groups and compared with plain GIC as control group. Physical and chemical characterization were conducted using nano-computerized tomography (NanoCT) and Fourier transform infrared spectroscopy.

Association of selected gene variants with nonsyndromic orofacial clefts in Kuwait.

Introduction And Objectives: Non-syndromic orofacial clefts (NSOFCs) are complex congenital abnormalities involving both environmental and genetic factors involved in orofacial development. This study aimed to investigate the genetic association of specific genetic variants at different CYRIA gene loci with the development of NSOFCs in Kuwait.

Methods: Four genetic variants (rs7552, rs3758249, rs3821949, and rs3917201) at four selected gene loci (CYRIA, FOXE1, MSX1, and TGFB3) were genotyped in a total of 240 DNA samples (patients (n = 114) and random controls (n = 126)) employing TaqMan® allele discrimination assay.

Recent research directions on functional royal jelly: highlights prospects in food, nutraceutical, and pharmacological industries.

The food and pharmaceutical industries have utilized royal jelly, an alternative medicinal food, as a natural pharmaceutical product since ancient times. Royal jelly has a unique remarkable composition containing lipids, proteins, carbohydrates, vitamins, minerals, hormones, and phenolic compounds. The rapidly expanding functional food market has coincided with the increasing consumer demand for royal jelly.

Lentil protein and trehalose conjugates: Structural interactions and mechanisms for improving multi-level structure and functional characteristics.

This study aimed to improve lentil proteins' (LPs) functionality and nutritional value, specifically addressing their lower water solubility and digestibility. A unique combination of LP-disaccharide interactions was employed. Spectroscopic technologies, which include fluorescence spectra, ultraviolet spectra, and Fourier-transform infrared, investigated the structure of LPs at various concentrations of trehalose.

Machine learning-based remission prediction in rheumatoid arthritis patients treated with biologic disease-modifying anti-rheumatic drugs: findings from the Kuwait rheumatic disease registry.

Background: Rheumatoid arthritis (RA) is a common condition treated with biological disease-modifying anti-rheumatic medicines (bDMARDs). However, many patients exhibit resistance, necessitating the use of machine learning models to predict remissions in patients treated with bDMARDs, thereby reducing healthcare costs and minimizing negative effects.

Objective: The study aims to develop machine learning models using data from the Kuwait Registry for Rheumatic Diseases (KRRD) to identify clinical characteristics predictive of remission in RA patients treated with biologics.

A Core set of patient-reported outcome measures to measure quality of life in obesity treatment research.

The lack of standardization in patient-reported outcome measures (PROMs) has made measurement and comparison of quality of life (QoL) outcomes in research focused on obesity treatment challenging. This study reports on the results of the second and third global multidisciplinary Standardizing Quality of life measures in Obesity Treatment (S.Q.

Dysregulation of the DRAIC/SBK1 Axis Promotes Lung Cancer Progression.

Long non-coding RNAs (lncRNAs) are key regulators of cellular processes that underpin cancer development and progression. DRAIC is a migration inhibitor that has been linked with lung adenocarcinoma progression; however, its mechanisms remain to be studied. Several bioinformatics tools were used to explore the role of DRAIC in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC).

c-Jun N-terminal Kinase Supports Autophagy in Testicular Ischemia but Triggers Apoptosis in Ischemia-Reperfusion Injury.

Oxidative stress triggered by testicular torsion and detorsion in young males could negatively impact future fertility. Using a rat animal model for testicular IRI (tIRI), we aim to study the induction of autophagy (ATG) during testicular ischemia and tIRI and the role of oxidative-stress-induced c-Jun N-terminal Kinase (JNK) as a cytoprotective mechanism. Sixty male Sprague-Dawley rats were divided into five groups: sham, ischemia only, ischemia+SP600125 (a JNK inhibitor), tIRI only, and tIRI+SP600125.

Notoginsenoside R1, a metabolite from Panax notoginseng (Burkill) F.H.Chen, stimulates insulin secretion through activation of phosphatidylinositol 3-kinase (PI3K)/Akt pathway.

Background: For ages, botanical medicine has been used in the treatment of diabetes mellitus (DM). Notoginsenoside R1 (NGR1), a Panax notoginseng (Burkill) F.H.

Enhancing craniofacial bone tissue engineering strategy: integrating rapid wet chemically synthesised bioactive glass with photopolymerized resins.

Background: Craniofacial bone regeneration represents a dynamic area within tissue engineering and regenerative medicine. Central to this field, is the continual exploration of new methodologies for template fabrication, leveraging established bio ceramic materials, with the objective of restoring bone integrity and facilitating successful implant placements.

Methods: Photopolymerized templates were prepared using three distinct bio ceramic materials, specifically a wet chemically synthesized bioactive glass and two commercially sourced hydroxyapatite variants.

Recoverable and reusable light-induced multi-arm azobenzenes-FeO hybrid sorbent for enrichment of phthalate plasticizer and utilized as a SALDI substrate for the detection of 2-naphthol.

The construction, structural identifications along with compositional properties, using TEM, FT-IR, and XPS spectroscopies, of an innovative light-induced multi-arm azobenzenes based FeO magnetic nanoparticles (Azo-FeO MNPs) are being reported. Such organic (light-sensitive dendrimers-like structure), inorganic (magnet core), hybrid material has been applied as an efficient recoverable/reusable extractive sorbent for the detection of phthalate plasticizers from acetate buffer solution. The extraction study was controlled within consecutive procedures via UV-light exposure to achieve pore-size control which then further subjected for the evaluation of the analytes' retention, separation, and release as well as the detection of the phthalate pollutants using GCMS-.

Mapping the Dental Applications of Nanosilver Fluoride: A Narrative Review.

Unlabelled: Advances in nanotechnology have been changing the face of dentistry with their diverse range of dental applications. Silver nanoparticles (AgNPs) are a relatively new breakthrough in dentistry.

Aim: The main objective of this paper is to discuss the current progress in the field of dentistry and highlight the aspects regarding silver nanoparticle incorporation, emphasizing the properties, applications, and advantages of nanosilver fluoride (NSF) that it brings to dentistry.

Explainable AI and optimized solar power generation forecasting model based on environmental conditions.

This paper proposes a model called X-LSTM-EO, which integrates explainable artificial intelligence (XAI), long short-term memory (LSTM), and equilibrium optimizer (EO) to reliably forecast solar power generation. The LSTM component forecasts power generation rates based on environmental conditions, while the EO component optimizes the LSTM model's hyper-parameters through training. The XAI-based Local Interpretable and Model-independent Explanation (LIME) is adapted to identify the critical factors that influence the accuracy of the power generation forecasts model in smart solar systems.

Safety and Effectiveness of Two Different Fluid-Filled Intragastric Balloons: A Single Center Experience.

Objective: The aim of the study is to compare weight loss and safety outcomes of two different commonly available fluid-filled intragastric balloons (IGBs) used for weight loss.

Method: A retrospective cohort study of a prospectively maintained database of adult patients who underwent IGB insertion between July 2020 and November 2021 in a single private clinic in Kuwait. The patient either received the Elipse™ or Orbera365™ balloon and was followed until the end of treatment.

Reproductive and oncologic outcomes in young women with uterine sarcoma undergoing fertility-sparing treatment: a systematic review.

Background: Uterine sarcomas (US) are rare cancer of possible occurrence even in women of childbearing age. To date, total hysterectomy is the standard treatment in the early stages. The possibilities of carrying out fertility-sparing treatments (FST) to save the fertility of women with unfulfilled reproductive desires are described in the literature, but to date, they can only be considered experimental.

Investigating the impact of shear and bulk viscosity on the damping of confined acoustic modes in phononic crystal sensors.

Phononic crystal (PnC) sensors are recognized for their capability to control acoustic wave propagation through periodic structures, presenting considerable potential across various applications. Despite advancements, the effects of fluid viscosity on PnC performance remain intricate and inadequately understood. This study theoretically investigates the influence of shear (dynamic) and bulk viscosity on acoustic wave damping in defective one-dimensional phononic crystal (1D PnC) sensors designed for detecting liquid analytes.

Rhabdomyolysis Induced by Levetiracetam: A Case Report in Kuwait.

Epilepsy is a common disorder caused by a myriad of drugs, of that levetiracetam is being commonly used late because of its strong safety profile and efficacy. With the increasing usage of drugs, some rare side effects may sometimes appear that can escape the most stringent checks, possibly due to the rarity of their occurrence. Rhabdomyolysis is known to occur in some patients owing to a variety of causes, even leading to kidney injury.

Mapping at Early and Late Stages of Infection in a Clinically Representative Hip Prosthetic Joint Infection Rat Model.

Prosthetic joint infection (PJI) continues to be a devastating complication following total joint replacement surgeries where is the main offending organism. To improve our understanding of the disease pathogenesis, a histological analysis of infected peri-implant tissue in a hip PJI rat model was utilized to assess spread and tissue reaction at early and late stages of infection. Sprague-Dawley rats were used and received a left cemented hip hemiarthroplasty using a 3D-printed titanium femoral stem.