Effects of Short-Term Annealing on the Thermal Stability and Microstructural Evolution of Oxygen-Free Copper Processed by High-Pressure Torsion.

This study explores the impact of short-term annealing on the thermal stability and mechanical properties of oxygen-free copper subjected to high-pressure torsion (HPT). Copper samples were deformed through HPT with varying numbers of turns at room temperature and subsequently subjected to short-term annealing at temperatures of 398 K and 423 K. Microstructural analysis revealed that annealing led to grain growth and a reduction in dislocation density, with samples processed with fewer HPT turns exhibiting more significant grain coarsening.

Radiogenomics Pilot Study: Association Between Radiomics and Single Nucleotide Polymorphism-Based Microarray Copy Number Variation in Diagnosing Renal Oncocytoma and Chromophobe Renal Cell Carcinoma.

RO and ChRCC are kidney tumours with overlapping characteristics, making differentiation between them challenging. The objective of this research is to create a radiogenomics map by correlating radiomic features to molecular phenotypes in ChRCC and RO, using resection as the gold standard. Fourteen patients (6 RO and 8 ChRCC) were included in the prospective study.

Unlocking Molecular Fingerprint of an Ombrotrophic Peat Bog: Advanced Characterization Through Hexamethyldisilazane Thermochemolysis and Principal Component Analysis.

This study examines a boreal peatland (the Sagnes peatland, Fanay, Limousin, France) with a depth of 1 m. This peatland is currently in the late stages of organic deposition, as evidenced by the growth of species, along with mosses, in the uppermost level. To gain molecular insights, we conducted an analysis of the lignin and polyphenolic counterparts using HMDS (hexamethyldisilazane) thermochemolysis, enabling the identification of lignin degradation proxies.

Mitigating Algorithmic Bias in AI-Driven Cardiovascular Imaging for Fairer Diagnostics.

: The research addresses algorithmic bias in deep learning models for cardiovascular risk prediction, focusing on fairness across demographic and socioeconomic groups to mitigate health disparities. It integrates fairness-aware algorithms, susceptible carrier-infected-recovered (SCIR) models, and interpretability frameworks to combine fairness with actionable AI insights supported by robust segmentation and classification metrics. : The research utilised quantitative 3D/4D heart magnetic resonance imaging and tabular datasets from the Cardiac Atlas Project's (CAP) open challenges to explore AI-driven methodologies for mitigating algorithmic bias in cardiac imaging.

Future Energy Breakthroughs: Implications for the Hydrocarbon Economies of the Arabian Gulf.

Countries in the Arabian Gulf are reliant upon hydrocarbons for revenues, exports, industries and funding services. It is largely assumed that the global energy transition will be gradual, as reflected in planning and strategy documents. However, energy breakthroughs can change the global energy system.

Comparative Efficacy of Endoscopic Versus Open Surgical Techniques in the Management of Gastric Outlet Obstruction: A Systematic Review.

Gastric outlet obstruction (GOO) is a clinical condition that can arise from both benign and malignant causes, requiring effective management strategies to ensure optimal patient outcomes. Traditionally, open surgical techniques like gastrojejunostomy (GJ) have been the standard treatment, but recent advances in minimally invasive procedures, such as endoscopic ultrasound-guided gastroenterostomy (EUS-GE), offer alternative approaches with potentially reduced morbidity. This systematic review compared the efficacy, safety, and clinical outcomes of endoscopic versus open surgical techniques in managing GOO.

Date palm (Phoenix dactylifera) bioactive constituents and their applications as natural multifunctional ingredients in health-promoting foods and nutraceuticals: A comprehensive review.

Foods that support human health and longevity are becoming increasingly relevant as substitutes for or adjuncts to pharmacological drugs, either through direct consumption or incorporation into designer foods fortified with health-promoting ingredients. Date palm (Phoenix dactylifera L.) fruits, seeds, and pollen are a cornerstone of diverse food and medicine traditions.

Feasibility and safety of autologous cord blood derived cell administration in extremely preterm infants: a single-centre, open-label, single-arm, phase I trial (CORD-SaFe study).

Background: Evidence from preclinical studies in small and large animal models has shown neuroprotective effects of intravenous administration of umbilical cord blood derived cells (UCBCs). This study aimed to evaluate the feasibility of umbilical cord blood (UCB) collection, extraction of UCBCs, and subsequent safety of intravenous autologous administration of UCBCs in extremely preterm infants (born <28 weeks gestation).

Methods: A single-centre, open-label, single-arm, safety and feasibility clinical intervention trial was conducted at Monash Medical Centre and Monash Children's Hospital, Melbourne, Australia.

Age-period-cohort modeling of oesophageal carcinoma risk in a middle eastern country: 1980-2019.

Background: Understanding of the factors influencing oesophageal cancer trends is crucial. Therefore, this cross-sectional cohort study sought to disentangle the age, period and cohort effects on the trends of oesophageal cancer in Kuwait.

Methods: The data on incident oesophageal carcinoma cases diagnosed between January 1, 1980, through December 31, 2019, and reference population were obtained.

Military Nurses' Deployment Experiences: A Qualitative Metasynthesis.

Introduction: Military medical personnel, including nurses, face a wide array of emotional and psychological issues while deployed. Understanding the challenges military nurses face in the deployed setting may prove useful in effectively preparing nurse leaders for future disaster responses in the military and civilian sectors. The purpose of this metasynthesis is to answer the following research question: What are the experiences of U.

Occupational health in the Gulf Cooperation Council (GCC): A systematic review and call for comprehensive policy development.

Background: This systematic review evaluates occupational health within the Gulf Cooperation Council (GCC) countries, focusing on ergonomic, physical, chemical, and biological hazards. It identifies significant impacts of these hazards across various professions and underscores the highlights for region-specific strategies and further research.

Methods: A comprehensive search in Scopus, PubMed, and Web of Science databases until October 2023 targeted occupational health studies in the GCC, adhering to PRISMA guidelines and NIH Quality Assessment Tools.

Perspectives of paediatric occupational therapists on the use of evidence-based practice in Kuwait: a qualitative study.

Objectives: To investigate the perspectives of paediatric occupational therapists on factors relating to the use of evidence-based practice (EBP) in clinical practice/settings.

Design: A qualitative approach entailing the use of (face-to-face) semistructured interviews. Collected data were analysed using thematic analysis.

A systematic risk spillover perspective for modelling China's energy security: Firm-level evidence.

The concept of energy security has gained extensive attention in academic interest. We use firm-level data to evaluate China's energy security from 2013 to 2022. The newly devised energy security index reveals temporal variability, particularly during extreme events.

Screening Asian Medicinal Plants for SARS-CoV-2 Inhibitors: A Computational Approach.

This work aimed to evaluate the antiviral potential of compounds from Asian medicinal plants against SARS-CoV-2's main protease and spike glycoprotein, identifying dual inhibitors from these plants that target both proteins through advanced virtual screening, molecular dynamics simulations, and pharmacophore analysis. An in-house library of 335 antiviral natural products was prepared from the selected medicinal plants. Following the virtual screening of this library against the main protease and spike glycoprotein, top compounds were subjected to downstream analysis for evaluating druggability potential and toxicity analysis.

Integration of validated functional evidence to support the pathogenicity of variants.

Functional investigation of genetic variants found in long QT syndrome can provide evidence that is needed to confirm the genetic diagnosis and establish the cause of the condition. We performed functional assessment to determine the -score, using a clinically calibrated automated patch clamp assay, for 2 missense variants found in 2 families that have been diagnosed with long QT syndrome. These variants are currently classified as variant of uncertain significance in ClinVar.

A case study for Kuwait mortality during the consequent waves of COVID-19.

The World Health Organization (WHO) announced on March 11, 2020, that COVID-19 could be considered a pandemic. This epidemic has become a huge issue for academics, doctors, healthcare providers, epidemiologists, and decision-makers alike. Motivated by studying natural phenomena, we concentrated on making a statistical model capable of fitting natural pandemics into the whole world.

An MCDM approach on Einstein aggregation operators under Bipolar Linear Diophantine Fuzzy Hypersoft Set.

The most extended form of a fuzzy set called the Bipolar Linear Diophantine Fuzzy Hypersoft Set is implemented with some basic operations. This is an extraordinary technique for handling uncertainty because it has a choice of reference parameters with auxiliary attributes. A widely used operator named Einstein aggregation operators was developed in our proposed context.

Phytochemical profiling and evaluation of compounds targeting Leishmania N-myristoyltransferase: molecular docking, drug-likeness, and toxicity analyses.

Background: has long been recognized for its therapeutic properties against various diseases. Among these is leishmaniasis, a parasitic infection that remains a global health challenge. Targeting Leishmania N-myristoyltransferase (NMT), a crucial enzyme for parasite survival, represents a promising therapeutic approach.

Further delineation of the SCAF4-associated neurodevelopmental disorder.

While mostly de novo truncating variants in SCAF4 were recently identified in 18 individuals with variable neurodevelopmental phenotypes, knowledge on the molecular and clinical spectrum is still limited. We assembled data on 50 novel individuals with SCAF4 variants ascertained via GeneMatcher and personal communication. With detailed evaluation of clinical data, in silico predictions and structural modeling, we further characterized the molecular and clinical spectrum of the autosomal dominant SCAF4-associated neurodevelopmental disorder.

Assessment of the ability of Lactococcus lactis 537 to bind aflatoxin M1 in the presence of inulin and Terminalia ferdinandiana (Kakadu plum).

One promising method for the detoxification of Aflatoxin M1 (AFM1) involves the use of probiotic bacteria combined with prebiotics. This approach is both safe and cost-effective, while also offering additional health benefits. The objective of this study was to investigate the capacity of Lactococcus lactis 537 (Lc.

The first report of two new janiroid isopod species (Asellota, Janiroidea) from the western Indian Ocean.

Two new janiroid isopod species, and , are described from the Kuwaiti waters, representing the first record of the genera in the western Indian Ocean. is distinguished from its congeners by pereonites 2-7 with a pair of short single lateral spine-like processes; the relatively short length of the anterior part of its pleotelson, which accounts for about 0.1 of the total length of the pleotelson; and the stylet with an elongate, downwardly curved, and distally pointed apex.

A rare case of isolated nasal tip neurofibroma in an 11-year-old female without neurofibromatosis: A case report.

Introduction And Importance: Isolated neurofibromas of the nasal tip are uncommon, particularly in pediatric patients. Neurofibromas are benign tumors that arise from the peripheral nerve sheath and are usually associated with neurofibromatosis type 1 (NF1). Isolated cases present unique challenges due to their location and the importance of cosmetic outcomes.

De novo Presentation of Systemic Lupus as Bullous Erythematosus: A Case Report.

Background: Systemic Lupus Erythematosus (SLE) (C1) is a disease with multi-organ involvement that can have a variety of cutaneous manifestations in 76% of cases during the disease. Less than 1% of these patients are diagnosed with confirmed bullous systemic lupus erythematosus (C1). Given the wide differential diagnosis of a bullous lesion, it is imperative to reach a conclusive diagnosis as it can have a direct impact on the course of management of the disease.