Cardiovascular Effects of Splenomegaly and Splenectomy in Beta-Thalassemia Major.

Background Beta-thalassemia major is a genetic blood disease complicated by splenomegaly, and splenectomy is a standard therapy for this medical condition. Although splenectomy results not only in the improvement of the hematological status, the long-term consequences to the cardiovascular system are still questionable. Objective The aim of the study was to assess and compare the cardiovascular impact of splenomegaly and splenectomy in patients with beta-thalassemia major.

-5,15-Bis[3-(iso-propyl-idenegalacto-pyran-oxy)phen-yl]-10,20-bis-(4-methyl-phen-yl)porphyrin.

The crystal structure of a glycosyl-ated porphyrin () system, CHNO, where two iso-propyl-idene protected galactose moieties are attached to the position of a substituted tetra-aryl porphyrin is reported. This structure reveals that the parent porphyrin is planar, with the galactose moieties positioned above and below the porphyrin macrocycle. This orientation likely prevents porphyrin-porphyrin H-type aggregation, potentially enhancing its efficiency as a photosensitizer in photodynamic therapy.

Superior pancreaticoduodenal artery pseudoaneurysm with subsequent : an unusual complication of chronic pancreatitis.

The development of an arterial pseudoaneurysm is an unusual complication of chronic pancreatitis. The most commonly involved artery is the splenic artery. This is a case report describing a case of a superior pancreaticoduodenal artery pseudoaneurysm in a patient with chronic pancreatitis who developed .

Modern-Day Management of the Dysglycemic Continuum: An Expert Viewpoint from the Arabian Gulf.

Prediabetes is the first stage of a continuum that extends through the diagnosis of clinical type 2 diabetes towards long-standing diabetes with multiple comorbidities. The diagnosis of prediabetes provides an opportunity to interrupt the diabetes continuum at an early stage to ensure long-term optimization of clinical outcomes. All people with prediabetes should receive intervention to improve their lifestyles (quality of diet and level of physical activity), as this has been proven beyond doubt to reduce substantially the risk of conversion to diabetes.

Effect of Smell and Taste of Milk on Feeding Parameters in Preterm Neonates: An Updated Meta-Analysis.

Smell and taste sensations have been linked to positive outcomes in the feeding of premature infants, though the impact on the time required to transition to oral feeding remains unclear. This study aimed to evaluate the beneficial effects of smell and taste interventions on clinical outcomes in preterm infants. We conducted a search in PubMed, Scopus, Web of Science, and the Cochrane Central Register of Controlled Trials from inception through September 2024 for randomized controlled trials (RCTs) examining the effects of smell and taste on clinical outcomes in preterm infants with a gestational age of less than 34 weeks.

Status of robotic surgery in pediatric genitourinary tumors: A systematic review.

Innovative surgical approaches are crucial in pediatric oncology to enhance treatment outcomes and minimize morbidity. Robotic-assisted surgery (RAS) has shown promise in both surgical precision and recovery in pediatric patients. This systematic review aims to address this gap by examining the current role and impact of RAS in managing pediatric genitourinary tumors, focusing on its feasibility, safety, and patient outcomes.

Intrapolyp Steroid Injection for Nasal Polyposis: A Systematic Review and Network Meta-Analysis.

Objective: To conduct a systematic review and network meta-analysis to evaluate the safety and efficacy of intrapolyp steroid injection compared with oral steroids, nasal steroid wash, nasal steroid spray, and a control group in patients with chronic rhinosinusitis with nasal polyps (CRSwNP).

Data Sources: PubMed, Scopus, Web of Science, Embase, and CENTRAL.

Review Methods: Both randomized and non-randomized clinical trials were included.

Undergraduate student nurses' experience of using standardized patient simulation in mental health course: A qualitative study.

Objectives: The aim of this research was to explore the perceptions of Lebanese student nurses on use of standardized patient simulations in the undergraduate mental health course.

Design: A qualitative descriptive research design informed by descriptive phenomenology was employed.

Method: Semi-structed interviews were carried out among 19 student nurses at one major private university in Beirut.

Impact of telomere length for risk assessment and prognosis in papillary thyroid cancer depending on the clinicopathological features.

Objective: . Despite the establishment of a link between telomere status and carcinogenesis, lack of a consensus in the cancer specific pattern of telomere length has a severe impact on the use of relative telomere length (RTL) in cancer diagnosis. The disparity in assessing the relationship between telomere length and cancer risk is complex and may vary as it is influenced by other factors.

Deep ultraviolet Raman spectroscopic analysis of antihistamine drugs in oral fluid for forensic purposes.

Owing to its inherent nondestructive nature, rapid analysis and simplicity, Raman spectroscopy has emerged as a promising tool for forensic analysis of different bodily fluids, particularly oral fluid (OF). Accurate drug identification and quantification are essential for understanding the circumstances surrounding a case, such as whether it involves an overdose fatality, substance abuse, or drug trafficking. This study aims to evaluate the potential of using deep ultraviolet Raman spectroscopy (DUVRS) to detect the antihistamine cetirizine (CTZ) in liquid and solid OF samples.

Cosmetic Stature Lengthening: An Investigation Into Sociodemographic Determinants and Public Perceptions.

Introduction: Height is an important psychosocial indicator, with short stature linked to a poorer quality of life. This study investigates public perceptions and attitudes toward cosmetic stature lengthening, a surgical procedure designed to increase individuals' height without a standard necessity.

Methods: Using a mixed-methods approach, an online general population sample was surveyed using a crowdsourcing platform (Prolific Academic), which facilitates demographically representative samples.

Deprescribing attitudes and predictors among older adults attending geriatric clinics in Kuwait.

Deprescribing is defined as the reduction of medications to improve patient care. For effective deprescribing regular evaluation of medication adjustment regimens is required as it is documented to be an effective method to reduce polypharmacy and potentially inappropriate medications while improving patient well-being. Several factors, including patient-related aspects, influence the deprescribing process.

International Validation of a Novel PEACE Scale to Improve the Quality of Upper Gastrointestinal Mucosal Inspection During Endoscopy.

Introduction: The performance of a high quality esophagogastroduodenoscopy (EGD) is dependent on the mucosal cleanliness. Recently, the Polprep: Effective Assessment of Cleanliness in EGD (PEACE) scale was created to assess the degree of mucosal cleanliness during EGD. The aim of this study was to validate this scoring system in a cohort of international endoscopists.

Predicting individuals' behaviors during a pandemic: why we might have acted as we did during the COVID-19 pandemic.

Background: This study examined individual differences in how people behave in response to a pandemic - more specifically, the current coronavirus pandemic.

Participants And Procedure: A sample of 420 participants was recruited through the online data collection platform MTurk. Participants were directed via an online link to a Qualtrics survey.

Monosaccharide coating modulate the intracellular trafficking of gold nanoparticles in dendritic cells.

Dendritic cells (DCs) have emerged as a promising target for drug delivery and immune modulation due to their pivotal role in initiating the adaptive immune response. Gold nanoparticles (AuNPs) have garnered interest as a platform for targeted drug delivery due to their biocompatibility, low toxicity and precise control over size, morphology and surface functionalization. Our investigation aimed to elucidate the intracellular uptake and trafficking of AuNPs coated with different combinations of monosaccharides (mannose, galactose, and fucose) in DCs.

Altered metabolic function induced by Aβ-oligomers and PSEN1 mutations in iPSC-derived astrocytes.

Altered energy metabolism in Alzheimer's disease (AD) is a major pathological hallmark implicated in the early stages of the disease process. Astrocytes play a central role in brain homeostasis and are implicated in multiple neurodegenerative diseases. Although numerous studies have investigated global changes in brain metabolism, redox status, gene expression and epigenetic markers in AD, the intricate interplay between different metabolic processes, particularly in astrocytes, remains poorly understood.

Demographic factors, knowledge, attitude and perception and their association with nursing students' intention to use artificial intelligence (AI): a multicentre survey across 10 Arab countries.

Background: Artificial intelligence (AI) is becoming increasingly important in healthcare, with a significant impact on nursing practice. As future healthcare practitioners, nursing students must be prepared to incorporate AI technologies into their job. This study aimed to explore the associated factors with nursing students' intention to use AI.

A Prospective Evaluation of Chemokine Receptor-4 (CXCR4) Overexpression in High-grade Glioma Using Ga-Pentixafor (Pars-Cixafor™) PET/CT Imaging.

Background: While magnetic resonance imaging (MRI) remains the gold standard for morphological imaging, its ability to differentiate between tumor tissue and treatment-induced changes on the cellular level is insufficient. Notably, glioma cells, particularly glioblastoma multiforme (GBM), demonstrate overexpression of chemokine receptor-4 (CXCR4). This study aims to evaluate the feasibility of non-invasive Ga-Cixafor™ PET/CT as a tool to improve diagnostic accuracy in patients with high-grade glioma.

Convective heat transport in a porous wavy enclosure: Nonuniform multi-frequency heating with hybrid nanofluid and magnetic field.

This work investigates the dynamics of the hybrid nanofluidic convective heat transfer in a permeable thermal system under the influence of multifrequency heating and a magnetic field. The geometry comprises a wavy-walled cavity filled with a water-based hybrid nanoliquid (AlO-Cu-HO) in a saturated porous medium. The finite volume approach is applied to scrutinize the hydro-thermal characteristics resulting from bottom heating and side cooling, considering various flow-controlling parameters.

Minimally invasive intervention of forniceal rupture in a solitary functioning kidney: A case report.

Renal Forniceal rupture is a common urological emergency, most commonly due to an underlying ureteral obstruction. There is no standardized management for forniceal rupture. We report a 70-year-old female who presented with vague abdominal symptoms, and acute on Chronic Kidney Disease.

Exploring Hypoglycemic Ketoacidosis in Nondiabetic Patients on Tirzepatide: Is Starvation the Culprit?

BACKGROUND Tirzepatide is a long-acting glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist administered via subcutaneous injection for weight reduction and treating type 2 diabetes. CASE REPORT We report case series of hypoglycemic ketoacidosis after the use of tirzepatide to treat nondiabetic patients with obesity from Kuwait. The first case was a 29-year-old woman with a body mass index (BMI) of 32 kg/m² who developed abdominal pain and vomiting after increasing the dose to 5 mg subcutaneously in week 5 of treatment.