Prophylactic direct oral anticoagulants vs. low molecular weight heparin after urological surgery: A systematic review and meta-analysis.

Purpose: To compare the outcomes of using prophylactic direct oral anti-coagulants (DOAC) and low-molecular-weight heparin (LMWH) after major urologic surgery.

Materials And Methods: Systematic literature searches of MEDLINE, Embase, Web of Science, and Cochrane CENTRAL were performed up to 9 November 2023, and protocols were registered on PROSPERO (CRD42024494424). The primary outcomes were post-operative incidence of VTE and bleeding.

Sarcocystis Cymruensis in the Brown Rat (Rattus Norvegicus) from an Urban District in Kuwait: Detailed Morphologic and Molecular Characterization.

Purpose: The objective of the study was to establish the prevalence of Sarcocystis (Apicomplexa, Sarcocystidae) in brown rats from Jleeb Al-Shuyoukh, Kuwait, and to describe detected parasites using morphological and DNA analysis methods.

Methods: Ninety-eight brown rats (Rattus norvegicus) were examined for Sarcocystis spp. Obtained sarcocysts were investigated using light microscopy and electron microscopy.

Comparative Evolutionary Epidemiology of SARS-CoV-2 Delta and Omicron Variants in Kuwait.

Continuous surveillance is critical for early intervention against emerging novel SARS-CoV-2 variants. Therefore, we investigated and compared the variant-specific evolutionary epidemiology of all the Delta and Omicron sequences collected between 2021 and 2023 in Kuwait. We used Bayesian phylodynamic models to reconstruct, trace, and compare the two variants' demographics, phylogeographic, and host characteristics in shaping their evolutionary epidemiology.

Integrating Wi-Fi, Li-Fi, and BPL Technologies for a Secure Indoor Communication System.

In today's digital age, there is an increasing demand for integrated wireless and wired technologies; however, there is a difficulty in achieving secure and reliable communications within buildings and facilities. This paper presents a proposal for maintaining the infrastructure while expanding it to implement communication technologies with high transmission and reception speeds and high levels of data confidentiality to enhance the operational efficiency of organizations. Three main technologies have emerged as promising solutions for this purpose: Wi-Fi, Li-Fi, and BPL.

Bovine Colostrum in Pediatric Nutrition and Health.

Bovine colostrum (BC), the first milk secreted by mammals after birth, is a trending alternative source for supplementing infants and children, offering benefits for gut and immune health. Its rich components, such as proteins, immunoglobulins, lactoferrin, and glycans, are used to fortify diets and support development. Preterm development is crucial, especially in the maturation of essential systems, and from 2010 to 2020, approximately 15% of all premature births occurred at less than 32 weeks of gestation worldwide.

Coffee and Cardiovascular Health: A Review of Literature.

Cardiovascular disease is the leading cause of death worldwide and is on the rise. Diet is considered to be a key modifiable risk factor for reducing the incidence of cardiovascular disease. Dietary approaches have proved advantageous for preventing disease morbidity and mortality but tend to focus on fruit, vegetables, fiber, lean protein and healthy fats.

ANN-QSAR, Molecular Docking, ADMET Predictions, and Molecular Dynamics Studies of Isothiazole Derivatives to Design New and Selective Inhibitors of HCV Polymerase NS5B.

RNA polymerase (NS5B), serves as a crucial target for pharmaceutical interventions aimed at combating the hepatitis C virus (HCV), which poses significant health challenges worldwide. The present research endeavors to explore and implement a variety of advanced molecular modeling techniques that aim to create and identify innovative and highly effective inhibitors that specifically target the RNA polymerase enzyme. In this study, a QSAR investigation was carried out on a set of thirty-eight isothiazole derivatives targeting NS5B inhibition and thus hepatitis C virus (HCV) treatment.

Targeting mTOR Kinase with Natural Compounds: Potent ATP-Competitive Inhibition Through Enhanced Binding Mechanisms.

: The mammalian target of the rapamycin (mTOR) signaling pathway is a central regulator of cell growth, proliferation, metabolism, and survival. Dysregulation of mTOR signaling contributes to many human diseases, including cancer, diabetes, and obesity. Therefore, inhibitors against mTOR's catalytic kinase domain (KD) have been developed and have shown significant antitumor activities, making it a promising therapeutic target.

Altered Cellular Metabolism Is a Consequence of Loss of the Ataxia-Linked Protein Sacsin.

Mitochondrial dysfunction is implicated in the pathogenesis of the neurological condition autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), yet precisely how the mitochondrial metabolism is affected is unknown. Thus, to better understand changes in the mitochondrial metabolism caused by loss of the sacsin protein (encoded by the SACS gene, which is mutated in ARSACS), we performed mass spectrometry-based tracer analysis, with both glucose- and glutamine-traced carbon. Comparing the metabolite profiles between wild-type and sacsin-knockout cell lines revealed increased reliance on aerobic glycolysis in sacsin-deficient cells, as evidenced by the increase in lactate and reduction of glucose.

Association Between Severe Periodontitis and Cognitive Decline in Older Adults.

(1) Background: Periodontal disease, a progressive inflammatory condition, disrupts the oral microbiome and releases inflammatory cytokines, leading to systemic issues, including cognitive decline. This study investigates the association between severe periodontitis and cognitive decline, exploring the role of alkaline phosphatase (ALP), an enzyme linked to systemic inflammation, as an effect modifier. (2) Methods: We analyzed cross-sectional data from the 2013-2014 National Health and Nutrition Examination Survey (NHANES).

Application of the U-Net Deep Learning Model for Segmenting Single-Photon Emission Computed Tomography Myocardial Perfusion Images.

Background: Myocardial perfusion imaging (MPI) is a type of single-photon emission computed tomography (SPECT) used to evaluate patients with suspected or confirmed coronary artery disease (CAD). Detection and diagnosis of CAD are complex processes requiring precise and accurate image processing. Proper segmentation is critical for accurate diagnosis, but segmentation issues can pose significant challenges, leading to diagnostic difficulties.

The role of taxation in environmental sustainability in G-20 economies: A double dividend theoretical assessment.

This study analyses the influence of environmental taxes, renewable energy, economic growth, green innovation and financial development on environmental sustainability in G-20 countries from 1990 to 2022. To this end, the Method of Moments Quantile Regression (MMQR) was applied to obtain the reference results, complemented with Fully Modified Ordinary Least Square (FMOLS) and Driscoll-Kraay techniques to perform a comparative analysis. Our results confirm a negative relationship between environmental taxes and sustainability in all quantiles, although this relationship is only significant in the middle and upper quantiles.

Exploring the relationship between trauma, mental health, and occupational performance in health science center students.

Introduction: Attending university marks a pivotal yet stressful phase in students' lives, characterized by significant adjustments to a new environment that can impact mental, emotional, and physical well-being. The journey through the acceptance and admissions process into university introduces substantial challenges, academic performance and changes to daily life. Such challenges and corresponding conditions can be intensified for students entering university with prior traumatic experiences.

Motivational orientation and perception of active learning instruction by pre-service language teachers.

This study investigates the impact of active learning instruction on the motivational orientation of pre-service language teachers. The data were collected by using the AGQ-R and the StRIP questionnaire, and analyzed through repeated measures of MANOVAs and correlation coefficient. Pre-service language teachers reported a higher approach goal orientation emphasizing the desire to succeed rather than avoidance goal orientation, i.

Investigations on the synthesis and characterization of silver-doped MoO thin films for photocatalytic applications.

In this study, we aimed to enhance the photocatalytic performance of molybdenum oxide (MoO) thin films by doping with silver (Ag) via a spray pyrolysis technique. The primary objective for silver incorporation was intended to introduce additional energy levels into the band structure of MoO, improving its efficiency. Structural, optical, and photocatalytic properties were analyzed using X-ray diffraction (XRD) and optical spectroscopy.

Energy yield framework to simulate thin film CIGS solar cells and analyze limitations of the technology.

This study presents a comprehensive evaluation of Copper Indium Gallium Selenide (CIGS) solar technology, benchmarked against crystalline silicon (c-Si) PERC PV technology. Utilizing a newly developed energy yield model, we analyzed the performance of CIGS in various environmental scenarios, emphasizing its behavior in low-light conditions and under different temperature regimes. The model demonstrated high accuracy with improved error metrics of normalized mean bias error (nMBE) ~ 1% and normalized root mean square error (nRMSE) of  ~ 8%-20% in simulating rack mounted setup and integrated PV systems.

A real-world study to assess the disease control of moderate to severe atopic dermatitis in patients receiving dupilumab therapy, with atopic dermatitis control tool in Gulf countries.

Purpose/aim Of The Study: There is limited real-world evidence regarding the effectiveness and safety of dupilumab in Gulf countries. The study aimed to evaluate atopic dermatitis (AD) disease control in adult and adolescent patients (≥12 years) treated with dupilumab in Gulf countries.

Materials And Methods: This observational study included patients with moderate-to-severe AD who initiated dupilumab within 30 days.

Management of metastatic colorectal cancer: consensus in the Gulf Cooperation Council countries.

Colorectal cancer (CRC) represents a major public health challenge globally, particularly in the Gulf Cooperation Council (GCC) countries, where it is identified as the second most prevalent form of cancer. Despite advancements in management strategies, tailored guidelines specific to the Gulf region are lacking. This paper presents consensus recommendations developed by a panel of experts from the GCC countries to address this gap.

Prevalence of polycystic ovary syndrome among infertile women in the Gulf Cooperation Council (GCC) countries: A systematic review and meta-analysis.

Background: Polycystic ovary syndrome (PCOS) is a significant contributor to female infertility and other various metabolic disorders. This systematic review estimates the prevalence of PCOS among infertile women in the Gulf Cooperation Council (GCC) countries.

Methods: The study searched five databases (PubMed, Embase, CINAHL, Web of Science, and SCOPUS), from their inception to 2022 for observational studies conducted in GCC countries.

Unveiling nature's antidiabetic potential in Berberis orthobotrys seeds for alloxan-induced diabetic rats.

To illustrate the anti-diabetic properties of Berberis orthobotrys seeds was the aim of the current study. After a series of experiments, two doses of aqueous methanolic extract of the seeds were selected i.e.

Optimizing solar performance of CFTSe-based solar cells using MoSe as an innovative buffer layers.

In this study, we explore the photovoltaic performance of an innovative high efficiency heterostructure utilizing the quaternary semiconductor CuFeSnSe (CFTSe). This material features a kesterite symmetrical structure and is distinguished by its non-toxic nature and abundant presence in the earth's crust. Utilizing the SCAPS simulator, we explore various electrical specifications such as short circuit current (J), open circuit voltage (V), the fill factor (FF), and power conversion efficiency (PCE) were explored at a large range of thicknesses, and the acceptor carrier concentration doping (N).

Analysis of the stability of a predator-prey model including the memory effect, double Allee effect and Holling type-I functional response.

This study proposes and analyses a revised predator-prey model that accounts for a twofold Allee impact on the rate of prey population expansion. Employing the Caputo fractional-order derivative, we account for memory impact on the suggested model. We proceed to examine the significant mathematical aspects of the suggested model, including the uniqueness, non-negativity, boundedness, and existence of solutions to the noninteger order system.