Age-period-cohort modeling of oesophageal carcinoma risk in a middle eastern country: 1980-2019.

Background: Understanding of the factors influencing oesophageal cancer trends is crucial. Therefore, this cross-sectional cohort study sought to disentangle the age, period and cohort effects on the trends of oesophageal cancer in Kuwait.

Methods: The data on incident oesophageal carcinoma cases diagnosed between January 1, 1980, through December 31, 2019, and reference population were obtained.

Military Nurses' Deployment Experiences: A Qualitative Metasynthesis.

Introduction: Military medical personnel, including nurses, face a wide array of emotional and psychological issues while deployed. Understanding the challenges military nurses face in the deployed setting may prove useful in effectively preparing nurse leaders for future disaster responses in the military and civilian sectors. The purpose of this metasynthesis is to answer the following research question: What are the experiences of U.

Occupational health in the Gulf Cooperation Council (GCC): A systematic review and call for comprehensive policy development.

Background: This systematic review evaluates occupational health within the Gulf Cooperation Council (GCC) countries, focusing on ergonomic, physical, chemical, and biological hazards. It identifies significant impacts of these hazards across various professions and underscores the highlights for region-specific strategies and further research.

Methods: A comprehensive search in Scopus, PubMed, and Web of Science databases until October 2023 targeted occupational health studies in the GCC, adhering to PRISMA guidelines and NIH Quality Assessment Tools.

Perspectives of paediatric occupational therapists on the use of evidence-based practice in Kuwait: a qualitative study.

Objectives: To investigate the perspectives of paediatric occupational therapists on factors relating to the use of evidence-based practice (EBP) in clinical practice/settings.

Design: A qualitative approach entailing the use of (face-to-face) semistructured interviews. Collected data were analysed using thematic analysis.

A systematic risk spillover perspective for modelling China's energy security: Firm-level evidence.

The concept of energy security has gained extensive attention in academic interest. We use firm-level data to evaluate China's energy security from 2013 to 2022. The newly devised energy security index reveals temporal variability, particularly during extreme events.

Screening Asian Medicinal Plants for SARS-CoV-2 Inhibitors: A Computational Approach.

This work aimed to evaluate the antiviral potential of compounds from Asian medicinal plants against SARS-CoV-2's main protease and spike glycoprotein, identifying dual inhibitors from these plants that target both proteins through advanced virtual screening, molecular dynamics simulations, and pharmacophore analysis. An in-house library of 335 antiviral natural products was prepared from the selected medicinal plants. Following the virtual screening of this library against the main protease and spike glycoprotein, top compounds were subjected to downstream analysis for evaluating druggability potential and toxicity analysis.

Integration of validated functional evidence to support the pathogenicity of variants.

Functional investigation of genetic variants found in long QT syndrome can provide evidence that is needed to confirm the genetic diagnosis and establish the cause of the condition. We performed functional assessment to determine the -score, using a clinically calibrated automated patch clamp assay, for 2 missense variants found in 2 families that have been diagnosed with long QT syndrome. These variants are currently classified as variant of uncertain significance in ClinVar.

A case study for Kuwait mortality during the consequent waves of COVID-19.

The World Health Organization (WHO) announced on March 11, 2020, that COVID-19 could be considered a pandemic. This epidemic has become a huge issue for academics, doctors, healthcare providers, epidemiologists, and decision-makers alike. Motivated by studying natural phenomena, we concentrated on making a statistical model capable of fitting natural pandemics into the whole world.

An MCDM approach on Einstein aggregation operators under Bipolar Linear Diophantine Fuzzy Hypersoft Set.

The most extended form of a fuzzy set called the Bipolar Linear Diophantine Fuzzy Hypersoft Set is implemented with some basic operations. This is an extraordinary technique for handling uncertainty because it has a choice of reference parameters with auxiliary attributes. A widely used operator named Einstein aggregation operators was developed in our proposed context.

Phytochemical profiling and evaluation of compounds targeting Leishmania N-myristoyltransferase: molecular docking, drug-likeness, and toxicity analyses.

Background: has long been recognized for its therapeutic properties against various diseases. Among these is leishmaniasis, a parasitic infection that remains a global health challenge. Targeting Leishmania N-myristoyltransferase (NMT), a crucial enzyme for parasite survival, represents a promising therapeutic approach.

Further delineation of the SCAF4-associated neurodevelopmental disorder.

While mostly de novo truncating variants in SCAF4 were recently identified in 18 individuals with variable neurodevelopmental phenotypes, knowledge on the molecular and clinical spectrum is still limited. We assembled data on 50 novel individuals with SCAF4 variants ascertained via GeneMatcher and personal communication. With detailed evaluation of clinical data, in silico predictions and structural modeling, we further characterized the molecular and clinical spectrum of the autosomal dominant SCAF4-associated neurodevelopmental disorder.

Assessment of the ability of Lactococcus lactis 537 to bind aflatoxin M1 in the presence of inulin and Terminalia ferdinandiana (Kakadu plum).

One promising method for the detoxification of Aflatoxin M1 (AFM1) involves the use of probiotic bacteria combined with prebiotics. This approach is both safe and cost-effective, while also offering additional health benefits. The objective of this study was to investigate the capacity of Lactococcus lactis 537 (Lc.

The first report of two new janiroid isopod species (Asellota, Janiroidea) from the western Indian Ocean.

Two new janiroid isopod species, and , are described from the Kuwaiti waters, representing the first record of the genera in the western Indian Ocean. is distinguished from its congeners by pereonites 2-7 with a pair of short single lateral spine-like processes; the relatively short length of the anterior part of its pleotelson, which accounts for about 0.1 of the total length of the pleotelson; and the stylet with an elongate, downwardly curved, and distally pointed apex.

A rare case of isolated nasal tip neurofibroma in an 11-year-old female without neurofibromatosis: A case report.

Introduction And Importance: Isolated neurofibromas of the nasal tip are uncommon, particularly in pediatric patients. Neurofibromas are benign tumors that arise from the peripheral nerve sheath and are usually associated with neurofibromatosis type 1 (NF1). Isolated cases present unique challenges due to their location and the importance of cosmetic outcomes.

De novo Presentation of Systemic Lupus as Bullous Erythematosus: A Case Report.

Background: Systemic Lupus Erythematosus (SLE) (C1) is a disease with multi-organ involvement that can have a variety of cutaneous manifestations in 76% of cases during the disease. Less than 1% of these patients are diagnosed with confirmed bullous systemic lupus erythematosus (C1). Given the wide differential diagnosis of a bullous lesion, it is imperative to reach a conclusive diagnosis as it can have a direct impact on the course of management of the disease.

Association of mitochondrial haplogroup H with reduced risk of type 2 Diabetes among Gulf Region Arabs.

Background: Numerous studies have linked mitochondrial dysfunction to the development of type 2 diabetes (T2D) by affecting glucose-stimulated insulin secretion in pancreatic beta cells and reducing oxidative phosphorylation in insulin-responsive tissues. Given the strong genetic underpinnings of T2D, research has explored the connection between mitochondrial DNA haplogroups, specific variants, and the risk and comorbidities of T2D. For example, haplogroups F, D, M9, and N9a have been linked to an elevated risk of T2D across various populations.

Draft genome sequence of a halophilic, putative hydrocarbon-degrading sp. strain KWT2.

We report the draft genome sequence of a halophilic, putative hydrocarbon-degrading sp. strain KWT2. The bacterium was isolated from a crude oil-contaminated saline pond in Kuwait.

Integration of pharmacophore-based virtual screening, molecular docking, ADMET analysis, and MD simulation for targeting EGFR: A comprehensive drug discovery study using commercial databases.

The epidermal growth factor receptor (EGFR), a crucial component of cellular signaling pathways, is frequently dysregulated in a range of cancers. EGFR targeting has become a viable approach in the development of anti-cancer medications. This study employs an integrated approach to drug discovery, combining multiple computational methodologies to identify potential EGFR inhibitors.

Clean and Efficient Green Protocol of ,'-Bis(2-(arylazo)-2-(aroyl)vinyl)ethane-1,2-diamines in Aqueous Medium without Catalyst: Synthesis and Photophysical Characterization.

An interesting platform for the construction of novel ,'-bis(2-(arylazo)-2-(aroyl)vinyl)ethane-1,2-diamines is reported in this work. These bis-arylazo compounds were assembled based on the reaction of ethylenediamine with various 2-arylhydrazono-3-oxopropanals in aqueous conditions under both conventional stirring and microwave conditions at ambient temperature. The factors affecting the optimization conditions were intensively practiced.

Nodular Posterior Scleritis Mimicking Non-pigmented Choroidal Melanoma: A Case Report and Literature Review.

Nodular posterior scleritis is an uncommon inflammatory disorder of the eye characterized by nodular lesions that may be similar to other intraocular conditions such as choroidal melanoma, leading to diagnostic difficulties. This case report and literature review aims to evaluate the demographics, modalities, treatment, and outcomes of nodular posterior scleritis. We describe a 41-year-old female patient who presented with diminished vision in her left eye.

The Utility and Limitations of Artificial Intelligence-Powered Chatbots in Healthcare.

At the intersection of artificial intelligence (AI) and healthcare, it is essential that clinicians grasp the ability of chatbots. AI-powered chatbots such as ChatGPT are being explored for their potential benefits by both individuals and institutions. The utility of ChatGPT (OpenAI) in various scenarios was explored through a series of recorded prompts and responses.

Enhancing energy balance in wireless sensor networks through optimized minimum spanning tree.

Wireless sensor networks (WSNs) are important for applications like environmental monitoring and industrial automation. However, the limited energy resources of sensor nodes pose a significant challenge to the network's longevity. Energy imbalances among nodes often result in premature failures and reduced overall network lifespan.

Assessment of knowledge and awareness of stroke among Arabic speaking adults: unveiling the current landscape in seven countries through the first international representative study.

Introduction: While several studies have examined stroke public knowledge and awareness in individual countries within the Middle East and North Africa (MENA) region, none have provided a comprehensive cross-country assessment.

Purpose: To assess public stroke knowledge and awareness among Arabic-speaking adults in seven MENA countries and identify associated factors.

Materials And Methods: An online cross-sectional survey was self-administered by the public population in Iraq, Lebanon, Sudan, Jordan, United Arab Emirates, Syria, and Saudi Arabia (April 2021-2023).