Impact of COVID-19 infection on cyclooxygenase-2 gene expression and mast cell count in testicular tissue of azoospermic men.

The COVID-19 pandemic has posed significant threats to human life and health. Numerous studies have shown that men are more vulnerable to this infection, and recent evidence suggests that the presence of angiotensin-converting enzyme 2 (ACE2) receptors in male reproductive tissues may particularly predispose them to viral infection. Therefore, it is crucial to assess the potential impact of COVID-19 infection on male fertility.

Tropisetron attenuates D-galactose-induced heart aging in male mice: activation of sirtuin1.

This study pursued to evaluate the tropisetron effects in attenuating D-galactose induced heart aging in mice. The study aimed to ascertain whether tropisetron affects apoptotic processes, mitochondrial oxidative stress, or inflammatory variables in cardiac tissue, presumably through the modulation of the SIRT1 signaling pathway or sirtuin 1. Aging was induced via administration of D-galactose (200 mg/kg, s.

Age- and sex-standardized prevalence of alcohol consumption and its determinants in the western region of Iran, Ilam: a cross-sectional study.

Background And Objective: In recent years, alcohol consumption in different parts of Iran has increased. However, this growth was dramatic in deprived regions. The percent study aimed to determine the age-sex standardized prevalence of alcohol consumption and related factors in the general population of Ilam city during 2021-2022.

The role of vitamin D in treated and refractory ulcerative colitis patients: a case-control study.

Background: Ulcerative colitis is a form of chronic inflammatory bowel disease (IBD) marked by ongoing inflammation of the mucosal lining that extends from the rectum to the upper part of the colon. Vitamin D regulates immune responses in several autoimmune and inflammatory diseases, including ulcerative colitis. Therefore, the study aims to investigate the role of vitamin D in the pathogenesis and treatment of ulcerative colitis.

Investigating miR-9 and miR-222 in CSF and Plasma of Neuroblastoma Patients as Metastatic and Apoptotic-Related Markers.

Neuroblastoma is a cancer that occurs due to abnormal development of the sympathetic nervous system. The dysregulation of miR-9 and miR-222 plays a crucial role in neuroblastoma development. These microRNAs have a significant relationship with PTEN, caspase-9, and MMP14, which can potentially form the basis for the specific diagnosis and treatment of this disease.

Teach back educational strategy on knowledge about breast cancer among low health literate women.

Background: This randomized controlled trial examines the effectiveness of a "teach-back" educational strategy in increasing knowledge about breast cancer among women with low health literacy.

Methods: Data collection for this study was conducted at the Farabi Comprehensive Health Services Center in Sanandaj, Iran, between December 2020 and October 2022. In this randomized controlled trial, 84 women who had low health literacy were randomly allocated into groups of the study (teach back, and control groups).

Coronary Artery Disease Empowerment Scale (CADES): Persian translation and psychometric properties.

Introduction: Coronary artery disease (CAD) is a leading cause of global mortality and a prevalent health issue in Iran. Assessing the empowerment of CAD patients during treatment and care is essential. However, no scale is available to measure empowerment in CAD patients in Iran.

COVID-19 vaccines: current and future challenges.

As of December 2020, around 200 vaccine candidates for Coronavirus Disease 2019 (COVID-19) are being developed. COVID-19 vaccines have been created on a number of platforms and are still being developed. Nucleic acid (DNA, RNA) vaccines, viral vector vaccines, inactivated vaccines, protein subunit vaccines, and live attenuated vaccines are among the COVID-19 vaccine modalities.

Health-related quality of life in adults with metabolic syndrome: a multi-level analysis of family and individual level variation.

Purpose: The current study aimed to investigate the associations between metabolic syndrome (MetS) with health-related quality of life (HRQoL) using multilevel analysis among the Iranian adult population.

Methods: This cross-sectional study was conducted in the framework of the Tehran Lipid and Glucose Study (TLGS). Participants were 6113 participants (3318 women and 2795 men) aged≥20 years of the TLGS seventh phase who had completed data on HRQoL and MetS.

Assessment of heavy metal contamination in groundwater of rural areas of Kurdistan Province Iran: A comprehensive study.

This study focuses on the contamination of groundwater by heavy metals (HMs) in the Kurdistan Province of Iran, an area heavily reliant on these water resources, especially in rural regions. This research aimed to quantify the concentrations of 20 HMs in groundwater sources and assess the associated health risks, including both carcinogenic and non-carcinogenic effects, for different age groups. The study was conducted in 2024.

CCN5/WISP2 serum levels in patients with coronary artery disease and type 2 diabetes and its correlation with inflammation and insulin resistance; a machine learning approach.

Introduction: Studies have shown various effects of CCN5/WISP2 on metabolic pathways, yet no prior investigation has established a link between its serum levels and CAD and/or T2DM. Therefore, this study seeks to explore the relation between CCN5 and the risk factor of CAD and/or diabetes, in comparison to individuals with good health, marking a pioneering endeavor in this field.

Methods: This case-control study investigates serum levels of CCN5, TNF-α, IL-6, adiponectin, and fasting insulin in a population of 160 individuals recruited into four equal groups (T2DM, CAD, CAD-T2DM, and healthy controls).

Exploring the ethical decision-making experience of caregivers of end stage cancer patients in Iran: a phenomenological study.

Background: Ethical decision making is a complex issue because it strongly depends on the religion, beliefs, traditional laws and moral views of each society. The purpose of this study was to explore the experience of Iranian family caregivers of end stage cancer patients about ethical decision making.

Methods: This qualitative study is based on van Manen's method of hermeneutic phenomenology.

Directing Rat Hair Follicle Stem Cells Toward Neuronal Lineage With Enhanced Trophic Factor Expression.

Background: Hair follicle stem cells (HFSCs) are promising candidates for cell-based therapies in neurodegenerative diseases because of their ability to differentiate into neural lineages and exert paracrine effects in damaged tissues. However, their clinical application faces challenges, particularly in efficiently guiding them toward neural lineages. This study explores using chick embryo extract (CEE) to enhance HFSCs' secretory capacity and neuronal differentiation.

Comparative study of lidocaine- saline versus saline as washout for lumpectomy cavity on acute postoperative pain.

Purpose: This study aimed to evaluate the impact of lidocaine-saline solution compared to saline alone for washing out the lumpectomy cavity, focusing on its effect on acute postoperative pain-a prevalent and significant concern among patients undergoing breast surgery.

Methods: In this comparative study, 72 patients scheduled for lumpectomy surgery were randomly assigned to either the lidocaine-saline or saline group. The lidocaine-saline group was administered a washout of the lumpectomy cavity with 2 % lidocaine at a dosage of 1.