Molecular dynamics simulations of ribosome-binding sites in theophylline-responsive riboswitch associated with improving the gene expression regulation in chloroplasts.

The existence of an efficient inducible transgene expression system is a valuable tool in recombinant protein production. The synthetic theophylline-responsive riboswitch (theo.RS) can be replaced in the 5[Formula: see text] untranslated region of an mRNA and control the translation of downstream gene in chloroplasts in response to the binding with a ligand molecule, theophylline.

Role of autologous blood patch pleurodesis for management of prolonged pulmonary air leak: A systematic review.

Prolonged air leak (PAL) represents the most commonly encountered complication following pulmonary resection. This review aims to show the role of autologous blood pleurodesis (ABPP) in the management of PAL. A search was conducted on the Web of Science, PubMed, MEDLINE, and Google Scholar for English-language articles until September 15, 2023, with titles containing the related phrase "autologous blood patch pleurodesis (ABPP), and prolonged air leaks.

The study of acceptability HIV self-testing among Iranian injecting drug users: a qualitative study.

Background: In 2016, The World Health Organization introduced HIV self-testing (HIVST) as an alternative to traditional HIV testing (1), the present study aims to study the acceptability of HIV self-testing among Iranian women injecting drug users (WIDUs). The results of this study are expected to provide valuable evidence for the proper implementation of this program in Iran.

Methods: This study employed a content analysis approach to gather qualitative data.

The effect of a caring program based on the Pender's health promotion model on caregiver burden in family caregivers of patients with chronic heart failure: A quasi-experimental study.

Background: The Pender's Health Promotion Model is a comprehensive solution to improve health and reduce the risk of chronic conditions. This study aimed to determine the effect of a care program based on the Pender's Health Promotion Model on the caregiving burden of family caregivers of patients with chronic heart failure.

Methods: This semi-experimental study with a control group was conducted at the Imam Khomeini Heart Clinic in Saqqez in 2022-2023.

Basic Reproduction Number (R0), Doubling Time, and Daily Growth Rate of the COVID-19 Epidemic: An Echological Study.

Introduction: In infectious diseases, there are essential indices used to describe the disease state. In this study, we estimated the basic reproduction number, R0, peak level, doubling time, and daily growth rate of COVID-19.

Methods: This ecological study was conducted in 5 provinces of Iran.

Hydrogel Encapsulation Techniques and Its Clinical Applications in Drug Delivery and Regenerative Medicine: A Systematic Review.

Hydrogel encapsulation is a promising carrier for cell and drug delivery due to its ability to protect the encapsulated entities from harsh physiological conditions and enhance their therapeutic efficacy and bioavailability. However, there is not yet consensus on the optimal hydrogel type, encapsulation method, and clinical application. Therefore, a systematic review of hydrogel encapsulation techniques and their potential for clinical application is needed to provide a comprehensive and up-to-date overview.

The Effects of Melatonin Alone or in Combination with Zinc on Gonadotropin and Thyroid Hormones in Female Rats.

Thyroid and gonadotropin hormones play an essential role in the regulation of regulating various physiological functions. The effects of melatonin and zinc (Zn) on these hormones have already been investigated. The aim of the present study was to investigate the effect of melatonin with and without zinc on the levels of gonadotropin hormones and thyroid hormones (triiodothyronine (T), thyroxine (T) and thyroid-stimulating hormone (TSH)) in female rats.

Surfactant administration methods for premature newborns: LISA vs. INSURE comparative analysis.

Introduction: Respiratory Distress Syndrome (RDS) is the most common respiratory disorder among premature infants. The use of surfactant has significantly reduced respiratory complications and mortality. There are two conventional methods for administering surfactant: Intubate-Surfactant-Extubate (INSURE) and Less Invasive Surfactant Administration (LISA).

Tuberculosis vaccine developments and efficient delivery systems: A comprehensive appraisal.

Despite the widespread use of the Bacillus Calmette-Guérin (BCG) vaccine, (MTB) continues to be a global burden. Vaccination has been proposed to prevent and treat tuberculosis (TB) infection, and several of them are in different phases of clinical trials. Though vaccine production is in progress but requires more attention.

Genetic Regulation of Interleukin-6 and Interleukin-10 in COVID-19 Infection.

Background: The role and regulation mechanisms of the interleukin-6 and 10 (IL6 and IL-10) serum levels and the interaction between CD4+ and CD8+ lymphocytes with SARS-COV-2 IgM and IgG in the context of COVID-19 infection are not fully understood.

Methods: This study was conducted on 45 COVID-19 patients and 45 healthy individuals. The IL-6 and IL-10 promoter methylation, IL-6 and IL-10 gene expression, SARS-COV-2 IgM, and IgG antibodies and CD4+ and CD8+ lymphocytes were studied by qMSP-PCR, Real-time PCR, ELISA, and flow cytometry techniques, respectively.

Nasopharyngeal Branchial Cyst and Thornwaldt Cyst in a Patient with Hearing Loss after Coronavirus Infection.

Introduction: The majority of nasopharyngeal cysts are asymptomatic and rare. Nevertheless, these lesions are rarely discovered during regular endoscopies and imaging tests. An upper nasopharyngeal Thornwaldt cyst is a benign, mucosal congenital cyst.

Role of residential greenspace in the trajectory of major neurological disorders: A longitudinal study in UK Biobank.

Background: Stroke and dementia are major neurological disorders that contribute significantly to disease burden and are interlinked in terms of risk. Nevertheless, there is currently no study investigating the influence of residential greenspace on the trajectory of these neurological disorders.

Methods: This longitudinal study utilized data from the UK Biobank.

T1 and T2 weighted lesions and cognition in multiple Sclerosis: A systematic review and meta-analysis.

Background: Considering the different results regarding the correlation between Magnetic Resonance Imaging (MRI) structural measures and cognitive dysfunction in patients with MS, we aimed to perform a systematic review and meta-analysis study to investigate the correlation between T1 and T2 weighted lesions and cognitive scores to find the most robust MRI markers for cognitive function in MS population.

Methods: The literature of this paper was identified through a comprehensive search of electronic datasets including PubMed, Scopus, Web of Science, and Embase in February 2022. Studies that reported the correlation between cognitive status and T1 and T2 weighted lesions in MS patients were selected.

Exploring medical students' perceptions and understanding of the health impacts of climate change: a qualitative content analysis.

Background: Climate change has been identified as the greatest threat to global health in the twenty-first century, with its unfavorable health consequences being among its impacts on humans. Exploring the perspectives and understanding of healthcare professionals and service providers concerning climate change becomes imperative. The aim of this study is to investigate the perceptions and understanding of final-year medical students regarding the health impacts of climate change on individuals and the healthcare system using a qualitative content analysis.

Ectopia cordis with multiple ventricular septal defect and sternal cleft in a newborn: a case report.

Unlabelled: Ectopia cordis is a rare type of malformation where the heart is not located normally. It may be partially or completely located outside the thoracic cavity and can be associated with other congenital abnormalities.

Case Presentation: This case report is of a 34-week- and 6-day-old female fetus with a birth weight of 2040 g, a height of 41 cm, and a head circumference of 32 cm.

The Effect of Psycho-education on the Affiliate Stigma in Family Caregivers of People with Bipolar Disorder.

Introduction: Paying attention to stigma among caregivers to provide proper care for patients is necessary, and promoting awareness (about mental illness and mental health) to taking care of the caregivers' health, is crucial.

Objective: This study aimed to investigate the effect of psycho-education on the affiliate stigma in family caregivers of people with bipolar disorder.

Method: This study is a quasi-experimental research with an experimental and control groups.

Recurrence and 5-year survival rate in patients with borderline ovarian tumors and related factors in Kurdistan.

The aim of this study was to investigate the recurrence rate and five-year survival in patients with borderline ovarian tumors and related factors. This retrospective cohort study was performed on 20 women diagnosed with a borderline ovarian tumor in Kurdistan province, Iran, between 2007 and 2019. Patients' records were reviewed and a researcher-made questionnaire was completed for each patient, which included demographic and clinical variables related to patient survival.

HIV prevalence and associated factors among female sex workers in Iran: a bio-behavioral survey in 2020.

Despite the overall decline in human immunodeficiency virus (HIV) prevalence, it remains unacceptably high in key populations. This study aimed to estimate prevalence of HIV infection and high-risk behaviors among female sex workers (FSWs). This study was a cross-sectional survey of FSWs conducted between December 2019 and August 2020 in eight geographically diverse cities in Iran.

Autologous hematopoietic stem cell transplantation in neuromyelitis optica spectrum disorder: A systematic review and meta-analysis.

Introduction: Treatment options for neuromyelitis optica spectrum disorder (NMOSD) are corticosteroids, immunosuppressive drugs, emerging monoclonal antibodies, rituximab, eculizumab, satralizumab, and inebilizumab. Due to disabling and deadly nature of NMOSD, there is a great motivation among physicians for finding new treatment options. Recently, several studies have been conducted on the therapeutic effects of autologous hematopoietic stem cell transplantation (AHSCT) on NMOSD patients.

Effect of cigarette smoke condensate on mouse embryo development and expression of pluripotency and apoptotic genes .

The aim of the present study was to investigate the effect of cigarette smoke condensate (CSC) on development of mouse embryos. In total 3000 NMRI mice 2PN embryos were divided into six groups ( = 500). The test group was exposed to 20, 40, 80, 160 or 320 μg/ml of CSC.

Role of the Wnt and GTPase pathways in breast cancer tumorigenesis and treatment.

Breast cancer (BC) is the most frequently diagnosed cancer among women in all the populations of the world. Although the BC mortality rate has declined, resistance to treatment is still a significant challenge for patient survival. Various cellular signaling pathways, such as Wnt and Rho/GTPase have been linked to the development, migration, and metastasis of BC, and also in treatment resistance mechanisms.

Changes in liver enzymes and association with prognosis in patients with COVID-19: a retrospective case-control study.

Objective: COVID-19 has recently emerged as a serious threat to global health. This study examined the laboratory investigations of patients with COVID-19, with an emphasis on liver enzymes.

Methods: This retrospective, single-center study was performed on patients with COVID-19 who were admitted to Imam Reza Hospital, Iran from March 2020 to February 2021.

SARS-CoV-2 seroprevalence around the world: an updated systematic review and meta-analysis.

Background: Covid-19 has been one of the major concerns around the world in the last 2 years. One of the challenges of this disease has been to determine its prevalence. Conflicting results of the serology test in Covid explored the need for an updated meta-analysis on this issue.

Clinical and radiological results of using proximal femoral locking compression plate and proximal femoral nail antirotation for subtrochanteric fractures.

The aim of this study was to evaluate the results of treatment of subtrochanteric femoral fracture in the use of proximal femoral locking compression plate (PFLCP) and proximal femoral nail antirotation (PFNA). This retrospective study was performed on patients who referred to Firoozgar Hospital in 2017 with subtrochanteric fracture. During follow-up, control radiographs were obtained from patients and the Harris Hip Score questionnaire was completed.

Pseudobulbar affect in neurodegenerative diseases: A systematic review and meta-analysis.

Background: Pseudobulbar affect (PBA) is characterized by uncontrolled episodes of crying and laughing which is associated with a variety of neurological diseases including traumatic brain injury, multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), brain tumors, stroke, Parkinson's disease (PD), Alzheimer's disease (AD) and other dementias. However, there is a lack of exact estimated prevalence of PBA among neurological disorders.

Aim: In this systematic review and meta-analysis study we aimed to assess the prevalence of PBA in four neurodegenerative diseases including ALS, MS, AD, and PD.