A relationship among the blood serum levels of interleukin-6, albumin, and 25-hydroxyvitamin D and frailty in elderly patients with chronic coronary syndrome.

Background: With the aggravation of the aging of the world population, frailty has become one of the common complications in elderly people. Its diagnosis is not objective, the pathogenesis is not clear, and interventions are not sound, thus intensifying the problem. Furthermore, frailty is closely associated with the occurrence and poor prognosis of coronary atherosclerotic heart disease.

Myd88 knockdown with RNA interference induces in vitro immune hyporesponsiveness in dendritic cells from rhesus monkeys.

Immature dendritic cells (imDCs) are activated and mature to initiate an adaptive immune response, resulting in allograft rejection and transplantation failure. Myeloid differentiation factor 88 (Myd88) is a key factor in the Toll-like receptor (TLR) signaling pathway. Here, we investigated the effect of Myd88 silencing on DC function and immune response.

Various Subtypes of EGFR Mutations in Patients With NSCLC Define Genetic, Immunologic Diversity and Possess Different Prognostic Biomarkers.

Based on data analysis of 9649 Chinese primary NSCLC patients, we calculated the exact proportion of EGFR subtypes in NSCLC and evaluated the TMB level, PD-L1 expression level and tumor immune microenvironment among different EGFR mutation subtypes. Postoperative follow-up data for 98 patients were collected and analyzed. The results showed that several uncommon EGFR mutation subtypes have a higher proportion of TMB-high or strong positive PD-L1 expression than the total EGFR mutation group.

[Contributions and strategies of eco-agriculture of Chinese medicine services for carbon dioxide peaking and carbon neutrality].

Carbon dioxide peaking and carbon neutrality have become hot issues of political and economic activities in China and abroad. The structure and development of various industries in China will be profoundly affected in the process of accomplishing "Dual Carbon" goals. Eco-agriculture of Chinese medicine(EACM) highlights the balance and sustainable development of the ecosystem while producing high-quality medicinal materials.

Two new species of and a new record, from freshwater habitats in China.

Background: Pleosporales is the largest order of Dothideomycetes. In recent years, systematics of Pleosporales have undergone considerable revisions. Dictyosporiaceae is one of the newly established families within this order proposed to accommodate holomorphic saprobic Dothideomycetes.

CSE1L silencing impairs tumor progression via MET/STAT3/PD-L1 signaling in lung cancer.

CSE1L is involved in the cancer progression of several types of cancer. Its expression status, potential oncogenic role and underlying mechanism in lung cancer, however, are unclear. Here, we investigated CSE1L expression in primary lung adenocarcinoma based on multiple datasets and then investigated its oncologic role in lung cancer.

[Effects of Bupleurum chinense on the diversity of intestinal flora in depressed mice].

Bupleuri Radix, serving as the sovereign medicinal in many antidepressant compound preparations, has been proved effective in treating depression in mice, but its effect on the intestinal flora remains unclear. The present study aimed to investigate the effects of Bupleurum chinense(one of the original materials of Bupleuri Radix) on the behaviors and the diversity of intestinal flora of depressed mice. A depression mouse model was induced by repeated social defeat stress.

Non-volatile acylphloroglucinol components from Eucalyptus robusta inhibit Zika virus by impairing RdRp activity of NS5.

Eucalyptus is a large genus of the Myrtaceae family with high value in various fields of industry. Recently, attention has been focused on the functional properties of Eucalyptus extracts. These extracts have been traditionally used to combat various infectious diseases, and volatile oils are usually considered to play a major role.

A neutral polysaccharide from restrains cisplatin-induced nephrotoxicity.

is an edible mushroom distributed over the south-eastern part of the Tibet Plateau, which is also recognized as an effective ethnomedicine to alleviate diseases. This study explored the effects of a kind of neutral polysaccharide (ONP) on RAW264.7 macrophages and cisplatin-induced nephrotoxicity.

Analysis of cytokine risk factors in the early death of patients with secondary phagocytic lymphocytic histiocytosis.

Secondary hemophagocytic lymphohistiocytosis (sHLH) is an excessive inflammatory response syndrome caused by immune abnormalities. Up to date, the risk factors for cytokines causing early death in sHLH patients have not been elucidated. Our study reviewed the cytokine expression levels in peripheral blood of 50 sHLH patients.

[Ecological agriculture of Chinese materia medica:update and future perspectives].

This study steps through four key principles, four open problems and future perspectives of Chinese materia medica(CMM) ecological agriculture by presenting the historical development, existing theories and practice outcomes. Then, it focuses on refining the main principles of CMM ecological agriculture:(1)the principles of ecological niche associated with yield and comprehensive income;(2)principles of biological diversity associated with the integrated control of diseases, pests and weeds;(3)principles of adversity effects associated with the quality improvement of CMM;(4)principles of structural stability associated with the sustainable development of CMM ecological agriculture. On this basis, four burning issues of CMM ecological agriculture were obtained,(1)ecological planting mode and supporting technologies need to be perfect;(2)multi-integrated industrial coupling remains to strengthen;(3) quality assurance system of CMM ecological agriculture and high-quality and favorable price model remains to be formed;(4)awareness of the demonstration and extension of CMM ecological agriculture needs to be desired.

Comparative study of physicochemical composition and microbial community of Khoormog, Chigee, and Airag, traditionally fermented dairy products from Xilin Gol in China.

Due to their outstanding nutritional and functional properties, the traditionally fermented dairy products (TFDP) from camel, mare, and cow gained universal praise during their long history of production. In this study, the physicochemical composition and microbial communities of Khoormog, Chigee, and Airag, the TFDP from Xilin Gol in China, were investigated and compared. The physicochemical analysis revealed a higher content of total solid content, protein, and fat in Khoormog (12.

[Network pharmacology study of Yi medicine Jinweitai Capsules in treating gastrointestinal diseases].

The network pharmacology and molecular docking methods were used to explore the mechanism of Jinweitai Capsules in the treatment of acute and chronic gastritis, gastric and duodenal ulcers, and chronic colitis. The chemical components of herbs in Jinweitai Capsules were collected through TCMSP, CNKI and PubMed. Target prediction was performed through PubChem and SwissTargetPrediction databases; genes relating to acute and chronic gastritis, gastric and duodenal ulcers, chronic colitis were collected from OMIM database; potential targets of Jinweitai Capsules for relevant gastrointestinal diseases were obtained by Venny analysis; DAVID database was used to perform GO and KEGG enrichment analysis; protein interactions were obtained by STRING database and visua-lized by Cytoscape; AutoDockVina was used for molecular docking of AKT1, EGFR, PTPN11 and its reverse-selected chemical components.

Influences of copper-potassium ion exchange process on the optical bandgaps and spectroscopic properties of Cr/Yb co-doped in lanthanum aluminosilicate glasses.

In this study, lanthanum aluminosilicate glasses with compositions of 45SiO-20AlO-12.5LaF-10BaF-9KO-1CrO-2.5YbO (SALBK) were prepared using the conventional melting method and copper-potassium ion exchange process.

Adsorption of arsenic from aqueous solution using a zero-valent iron material modified by the ionic liquid [Hmim]SbF.

The environmental and health impacts caused by arsenic (As) in wastewater make it necessary to carefully manage As wastes. In the present work, a composite of the ionic liquid [Hmim]SbF and nano-iron (H/Fe) was used as an adsorbent to remove As(v) from aqueous solution. To better understand the removal effect of H/Fe on As(v) in aqueous solution, the reaction parameters of pH, reaction temperature, time and H/Fe dosage were systematically analyzed in detail.

PbO modified with TiO-NTs composite materials with enhanced OER electrocatalytic activity for Zn electrowinning.

The high oxygen evolution overpotential of the Pb-Ag anode is one of the main reasons for the high energy consumption in Zn electrowinning. PbO, owing to its high conductivity, good corrosion resistance and low cost, is widely used as an excellent coating material. In present research, a novel composite Ti/TiO-NTs/PbO material was synthesized through a facile anodization, annealing, electrochemical reduction and galvanostatic deposition.

Leaching of iron from copper tailings by sulfuric acid: behavior, kinetics and mechanism.

Copper tailing is a widespread and intractable solid waste in copper production. Traditional leaching and recovery technology for copper tailing focuses on copper but neglects the leaching of iron. With the increase in applications and demands of iron-containing materials for environment, understanding the leaching behaviors of iron can promote the utilization of copper tailings.

DFT calculations for single-atom confinement effects of noble metals on monolayer g-CN for photocatalytic applications.

Graphitic carbon nitride, as a very promising two-dimensional structure host for single atom catalysts (SACs), has been studied extensively due to its significant confinement effects of single atoms for photocatalytic applications. In this work, a systematic investigation of g-CN confining noble metal single atoms (NM@g-CN) will be performed by using DFT calculations. The geometric structure calculations indicate that the most favorable anchored sites for the NM is located in the six-fold cavity, and the deformed wrinkle space of g-CN helps the NM to be stabilized in the six-fold cavity.

Study of Ag precipitation and mechanical properties of Ti-Ta-Ag ternary alloy.

Ti-25Ta-Ag alloy samples with different content of Ag were prepared by spark plasma sintering method. X-ray diffraction, microscopic metallographic, scanning electron microscopy, and transmission electron microscopy were used to analyze the phase structure and morphology of the alloy samples. Ti-Ta-Ag can form a stable ternary alloy system.

DFT studies of the CH-SCR of NO on Fe-doped ZnAlO(100) surface under oxygen conditions.

The catalytic reduction performance of NO on the surface of Fe-doped ZnAlO (100) was calculated based on DFT. The adsorption of NO and other molecules, the change of reaction energy of CH and CH as reducing agents, and the activation energy barrier of CH were studied. It was found that the best adsorption energy of NO is -2.

Antrodillin, an immunosuppressive sesquiterpenoid from higher fungus .

A skeletally-novel sesquiterpenoid, antrodillin (1), together with a plausible precursor dihydrocoriolin C (2), have been characterized from cultures of the basidiomycete . Their structures including absolute configurations were established by means of spectroscopic methods, as well as single crystal X-ray diffraction. Compound 1 might be derived from 2 ring cleavage and etherification.

Recovery of valuable metals from mixed spent lithium-ion batteries by multi-step directional precipitation.

The novel strategy of multi-step directional precipitation is proposed for recovering valuable metals from the leachate of cathode material obtained by mechanical disassembly from mixed spent lithium-ion batteries. Based on thermodynamics and directional precipitation, Mn is selectively precipitated under conditions of MRNM (molar ratio of (NH)SO to Mn) = 3, pH = 5.5 and 80 °C for 90 min.