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Overexpression of Jagged1 Ameliorates Aged Rat-Derived Endothelial Progenitor Cell Functions and Improves Its Transfusion Efficiency for Rat Balloon-Induced Arterial Injury.

Ann Vasc Surg

May 2017

Cell Biological Therapy Center, Cell Biological Medicine Integrated Engineering Laboratory of State and Region, Department of Clinical Laboratory, Kunming General Hospital of Chengdu Military Area Command of PLA, Kunming, Yunnan Province, People's Republic of China. Electronic address:

Background: Endothelial progenitor cell (EPC) has significant age-dependent alterations in properties, but the role of Jagged1 in aging-induced decline of EPC functions remains unclear.

Methods: 2- and 20-month old healthy male Sprague-Dawley rats were used in present study. Jagged1 gene transfection was performed in EPC isolated from aged (AEPC) and young rats (YEPC), respectively.

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