2 results match your criteria: "Kunming Army General Hospital[Affiliation]"
Converting Skin Fibroblasts into Hepatic-like Cells by Transient Programming.
J Cell Biochem
March 2016
Stanford University Medical School, Palo Alto, California.
Article Synopsis
- A new method allows the transformation of human skin fibroblasts into liver-like cells, which could serve as a potential therapy for end-stage liver disease.
- The fibroblasts were treated with fish egg extracts and then injected into fetal monkey and mouse livers, where they successfully differentiated and integrated into the liver tissue.
- This process involves activating specific signaling pathways that reactivate genes necessary for cell potency, suggesting that the approach is both feasible and cost-effective.
Transient in vitro epigenetic reprogramming of skin fibroblasts into multipotent cells.
Biomaterials
April 2010
The Research Center of Stem Cell, Tissue and Organ Engineering, Kunming Army General Hospital, Kunming 650032, PR China.
Article Synopsis
- Multipotent stem cells show promise for regenerative medicine, but their limited availability poses challenges for clinical use.
- Researchers developed an in vitro method to reprogram skin fibroblasts into multipotent cells, activating important stem cell markers like Oct4 and Nanog.
- The reprogrammed cells can differentiate into various cell types and form teratomas, while maintaining genomic imprinting, offering a safer alternative to traditional iPS cell methods.