Functional Outcome of Extensor Mechanism Salvage in Patella Fracture Non-union Using Krackow Sutures: A Case Report.

Patellar fractures can lead to extensor mechanism dysfunction if not repaired properly, impacting knee function and mobility, and this complication can be challenging to manage, especially in cases where previous surgical interventions have failed. The aim of this study was to evaluate the functional outcome of the salvaged extensor mechanism in patella fracture non-union using Krakow sutures in a 61-year-old female patient who presented with knee pain, reduced flexion, and a 40-degree extension lag after two previous patellar fracture surgeries using tension band wiring resulted in non-union. Despite rehabilitation attempts, her knee function remained compromised.

Chromium-histidine complex enhances reproductive physiology and development in Drosophila melanogaster by modulating oxidative stress.

The interaction of metal ions with biological systems plays a critical role in cellular functions, including oxidative stress regulation and metabolic health. This study aimed to explore the effects of the chromium-histidine complex [Cr(hist)] on reproductive success, developmental processes, and oxidative stress defence in Drosophila melanogaster. Wild-type D.

The Endodontic Treatment of Three-Rooted Maxillary Premolar Resembling a Small Molar: A Case Report.

An appropriate access cavity, sufficient cleaning, proper shape, and full obturation are necessary for a root canal to be successful. In the earliest stages of therapy, the location of all root canals within the tooth is crucial. Even if the morphology of most teeth is normal, some variations should be acknowledged.

Biogenic silver nanoparticles synthesized using bracken fern inhibits cell proliferation in HCT-15 cells through induction of apoptosis pathway and overexpression of heat shock proteins.

Background: In recent years, biosynthesized nanoparticles has shown a promise as alternative avenue for improving the effectiveness of conventional chemotherapy. Despite, there is a significant gap in existing literature concerning the comprehensive study of biogenic silver nanoparticles derived from terrestrial fern species and their potential effects on cancer cells. This study is aiming to investigate effects of biogenic silver nanoparticles synthesized using aqueous extract of bracken fern Pteridium revolutum on inhibiting cell proliferation and inducing apoptosis in HCT-15 cells.

Antimicrobial Resistance Profile of Enterococcal Isolates From Clinical Specimens at a Tertiary Care Hospital in Western Maharashtra, India.

Background , once benign intestinal flora, has transformed into formidable nosocomial pathogens as a result of the accelerated emergence of antibiotic resistance represents a major global health challenge, particularly within hospital settings. has grown more prevalent in nosocomial infections, such as urinary tract infections (UTIs), surgical site infections (SSIs) and bacteremia. The potential emergence of vancomycin-resistant (VRE) strains further complicates treatment choices for multi-drug resistant (MDR) infections.

Evaluation of Antibiotic Sensitivity in Methicillin-Resistant Staphylococcus aureus Isolates From Clinical Specimens in a Tertiary Care Hospital.

Background: Common Gram-positive bacteria can cause infections ranging from minor skin conditions to serious illnesses like sepsis.Methicillin-resistant (MRSA) emerged in the 1960s and now causes over 50% of hospital infections. In India, MRSA prevalence ranges from 25% in the west to 50% in the south.

Unlocking the Future: New Biologic Therapies for Rheumatoid Arthritis.

Rheumatoid arthritis (RA) is a chronic autoimmune disorder that leads to joint destruction and functional disability. Traditional treatments, including disease-modifying antirheumatic drugs (DMARDs), often fail, leaving many patients without remission. The advent of biologic therapies that target specific immune system components (e.

Bacteriological Profiles and Antimicrobial Susceptibility Patterns Among Isolates in Tonsillitis Patients Attending a Tertiary Care Hospital.

Background: Tonsillitis, primarily affecting children, is an inflammation of the pharyngeal tonsils caused by bacterial pathogens such as and or viral agents. It can be classified as acute, chronic, or recurrent based on episode duration and frequency. Effective treatment requires identifying causative pathogens and assessing antibiotic resistance patterns.

The Burden and Prevention of Human Papillomavirus (HPV) Infections and Cervical Cancer in India: A Literature Review.

Human papillomavirus (HPV) is a widespread viral infection affecting the reproductive tract and is associated with multiple types of cancer. It is a significant global health concern, with cervical cancer being one of the most common cancers affecting women worldwide. HPV infection has been found in both married and unmarried women.

Study of Coagulation Parameters in Gastrointestinal Malignancies.

Introduction  Gastrointestinal (GI) malignancies represent a diverse group of cancers affecting various parts of the digestive system. These malignancies encompass an important burden of cancer incidence and mortality globally, contributing to substantial morbidity and mortality worldwide. Studying the coagulation parameters of patients having GI malignancies is crucial for several reasons.

Effect of Lumbar Spinal Stabilization Exercises Along With Neural Tissue Mobilization on Pain and Spinal Dysfunction in Failed Back Surgery Syndrome.

Background Failed back surgery syndrome (FBSS) mainly involves back pain radiating to the lower limb after back-related surgeries. It can develop various complications around the operation site and its surrounding area. This study evaluates the effect of lumbar spinal stabilization exercises and neural tissue mobilization on pain and spinal dysfunction in FBSS.

Bacteriological Profile and Antibiogram Pattern of Wound Infection in a Tertiary Care Hospital.

Background and aim Wound infection constitutes a major barrier to healing and can have a harmful effect on the patient's quality of life and also on the healing rate of the wound. The widespread use of antibiotics, along with their extensive history of availability, has resulted in significant issues with resistant organisms contributing to morbidity and mortality. The study was conducted to determine the prevalence of bacterial species obtained from the wound sample and its antibiotic resistance pattern.

Theranostic Applications of Scaffolds in Current Biomedical Research.

Theranostics, a remarkable combination of diagnostics and therapeutics, has given rise to tissue/organ-format theranostic scaffolds that integrate targeted therapy and real-time disease monitoring. The scaffold is a 3D structuring template for cell or tissue attachment and growth. These scaffolds offer unprecedented opportunities for personalized medicine and hold great potential for revolutionizing healthcare.

Effect of Chest Proprioceptive Neuromuscular Facilitation on the Respiratory Status of Post-stroke Survivor: A Systematic Review.

Respiratory complications are one of those complications that can determine a patient's prognosis in the acute state and are a commonly neglected complication in the chronic state. Respiratory complications can range from improper ventilation profusion to thick copious secretion which can slow the prognosis. Respiratory complications need to be addressed in order to ensure a good ventilation perfusion and in the long run increase the patient's quality of life.

A Comparative Study of Frontal and Cerebellar Lobe Volumes Between Patients With First-Episode Schizophrenia and Healthy Controls and Its Association With Psychopathology and Neurological Soft Signs in Patients.

Objectives Our study aimed to investigate the fronto-cerebellar volumes in both patients and controls, as well as explore their relationship with symptomatology. Our primary objectives were to compare the frontal and cerebellar lobe volumetric measurements between patients with first-episode schizophrenia (FES) and healthy controls and to assess the relationship of these volumes with psychopathology, cognition, and neurological soft signs in FES patients. The secondary objective was to explore the association of fronto-cerebellar lobe volumes with socio-demographic factors among patients and controls, as well as the duration of untreated illness (DUI) among patients.

Outcomes of Microscopic vs. Endoscopic Tympanoplasty at a Tertiary Healthcare Institution in Western Maharashtra.

Introduction Chronic suppurative otitis media (CSOM) involves tympanic membrane perforation and is traditionally treated with microscopic tympanoplasty. Recent advancements in endoscopic techniques offer enhanced visibility and outcomes. This retrospective study compares endoscopic and microscopic tympanoplasty outcomes in CSOM patients between 2023 and 2024.

Citric acid crosslinked hydroxyethyl tamarind gum-based hydrogel films: A promising biomaterial for drug delivery.

This investigation explored citric acid crosslinked hydroxyethyl tamarind gum hydrogel films as a potential biomaterial for drug delivery. Hydroxyethylation of tamarind gum aimed to improve its solubility, swelling, and crosslinking potential. The synthesized hydroxyethylated tamarind gum (HETG) was comprehensively characterized, revealing the presence of hydroxyethyl groups and increased viscosity in comparison to unmodified tamarind gum.

Investigation of magnesium aluminometasilicate (Neusilin US2) based surface solid dispersion of sorafenib tosylate using QbD approach: and pharmacokinetic study.

Background And Purpose: Sorafenib tosylate (SFN), a potent multikinase inhibitor, is used for the treatment of various cancers. However, it shows limited therapeutic applications due to its poor biopharmaceutical properties. The aim of the present investigation is to develop surface solid dispersion (SSD) of SFN using adsorbent to improve its solubility, bioavailability and therapeutic efficacy.