67 results match your criteria: "Krishna Institute of Medical Sciences (Deemed to be University)[Affiliation]"

Sublingual (SL) buprenorphine has been used as a modality of managing acute postoperative pain in many studies. This systematic review aimed to investigate the safety and efficacy of SL buprenorphine as an analgesic for various surgeries. After registering the protocol with PROSPERO, we searched PubMed, Cochrane Library, and Ovid databases with relevant keywords.

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Objective: The purpose of this research intended to determine the impact of an multi-component exercise program on body composition and physical, emotional and social well being (PWB, EWB,SWB) in breast cancer survivors (BCS).  Methods: One hundred and thirty two eight women with BC were enrolled in this research based on inclusion and exclusion criteria and were randomized into group A and B. Group A received breast cancer (BC) support group therapy whereas group B received multi-component exercise program.

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Background: Breast surgery, radiation, chemotherapy and modified radical mastectomy (MRM) may cause long-term side effects such as decreased muscle strength, pulmonary function, cardio-respiratory fitness (CRF), altered body fat distribution and poor sleep quality. These short- and long-term repercussions have an enormous effect on physical functioning in this population. The goal of this research was to determine the effect of a multi-component exercise program on functional performance in breast cancer survivors.

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Article Synopsis
  • The study investigates the relationship between genetic variations in Cytochrome P450 (CYP) enzymes and the risk of gastrointestinal (GI) cancer in a rural population of Maharashtra, focusing on specific gene polymorphisms.
  • Using a case-control design with 200 GI cancer patients and 200 healthy controls, the researchers employed the PCR-RFLP method to analyze single-nucleotide polymorphisms (SNPs) in several CYP genes.
  • The results highlight that the variant allele of CYP2B6*5 is significantly linked to an increased risk of GI cancer, while certain alleles of CYP1B1 show a protective effect against the disease.
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Effect of Integrated Survivorship Model on Physical Health for Breast Cancer Survivors in Rural Area.

Asian Pac J Cancer Prev

February 2024

Department of Musculoskeletal Sciences, Krishna College of Physiotherapy, Krishna Vishwa Vidypeeth, KIMSDU, Karad, Maharashtra, India.

Objective: The objective of this study was to evaluate the effect of the integrated survivorship model on the physical health of breast cancer survivors in rural areas.

Methods:  Ninety-two patients who were breast cancer survivors were selected as per inclusion criteria and divided into two groups (control group and intervention group). The participants were randomly allotted to two groups of 46 each.

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Background: Last few decades, multiple studies all over the world revealed the association of genetic polymorphism in cytochrome P450 (CYP) genes with risk of developing different type of cancers, but contradictory outcomes were evidenced in case of cervical cancer (CC) risk. Therefore, the discrepancies in earlier reports influenced us to evaluate the association of CYP1A1*2A rs4646903, CYP1B1*3 rs1056836, CYP2C8*2 rs11572103, CYP2C9*2 rs1799853, CYP2C9*3 rs1057910, and CYP2C19*2 rs4244285 polymorphisms and CC susceptibility in the women of rural population of Maharashtra.

Materials And Methods: In this case-control study, genetic association of the polymorphisms in CYP genes was studied by using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) method.

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Objective: Resistance of Staphylococcus aureus (S. aureus) against common antibiotics has been increasing given the rampant use of antibiotics. Methicillin-resistant S.

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Background: Osteoarthritis of the knee causes pain and gait disturbances, as well as a distinct gait pattern. Patients with knee OA have decreased range of motion (ROM) and increased ground reaction force. OA reduces stride length and walking speed.

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Article Synopsis
  • - A case-control study in rural Maharashtra examined the connection between certain genetic variations (polymorphisms) in tumor suppressor genes p21 and p53 and breast cancer risk among women, involving 800 participants (400 breast cancer patients and 400 healthy controls).
  • - The study specifically focused on four single nucleotide polymorphisms (SNPs) in the p21 and p53 genes and utilized PCR-RFLP methods to analyze blood samples, assessing the genetic risk factors using odds ratios and logistic regression.
  • - Results showed that specific polymorphisms in the p21 gene, particularly the rs1801270 SNP, were negatively associated with breast cancer risk, indicating that certain genetic variations may offer some level of protection in
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Background: Distinguishing benign breast diseases (BBDs) from malignant breast diseases is a worrisome entity and should also have knowledge of the pattern of occurrence of the disorders in their geographical location. This research aimed to study the clinical and histopathological pattern of BBD in Indian patients.

Materials And Methods: The study was conducted on 153 specimens from lumpectomy, core needle biopsy, and mastectomy.

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Lack of identification of the root canal results in root canal treatment failure, one of the most frequent causes of root canal treatment failure. To successfully treat root canals, it is crucial to have a detailed understanding of root canal configuration, including distinguishing traits and anatomical differences. The root canal in the C form arrangement is among the most important anatomical variances.

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Background: Over the course of four decades, the bioactive materials have changed. They have become more specialized, more manageable, possessing superior qualities. Thus, it should be encouraged to conduct ongoing research to improve these materials even further in order to meet the growing clinical and restorative needs.

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Introduction: Recent advancements in biomedicine have revolutionized nanomedicine as a therapeutic moderator in the management of both infectious and noninfectious diseases.

Purpose: In the current study we demonstrated biosynthesis of gold nanoparticles using aqueous leaf extract of as a capping and reducing agent and evaluation of their antioxidant, antibacterial, and anticancer properties.

Methods: The biosynthesized LE-AuNPs were characterized by UV-Vis spectrophotometry, SEM, TEM, XRD, FTIR, DLS, and Zeta potential analysis.

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Background: Breast surgery, Axillary Lymph Node Dissection (ALND), radiation and chemotherapy may develop several complications such as axillary web syndrome, frozen shoulder, numbness, shoulder pain and range of motion restriction, lymphostasis, and lymphedema. Up to 77% report sensory disturbance in the breast or arm after breast surgery. These short- and long-term consequences have dramatic impact on physical function and quality of life in this population.

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Background And Objectives: The usage of a toothbrush with the most appropriate bristle type and a correct brushing technique are the most important factors in determining the thoroughness of plaque control. The dental undergraduate course conventionally does not impart tooth brushing techniques in the preclinical years. This study aimed to assess the effect of an educational intervention of correct tooth brushing technique on the wear of toothbrush bristles by light microscopic examination amongst the budding dental professionals.

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Background: Posttraumatic facial scars are not only unaesthetic but also have a negative sociopsychological impact. Surgeons constantly try to achieve the most aesthetic scar by various suturing methods. The tensile forces acting on the edges of the wound during healing are a major factor in determining the final appearance of a scar.

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Prevalence of oral potentially malignant disorders (OPMD) in adults of Western Maharashtra, India: A cross-sectional study.

J Cancer Res Ther

December 2022

Departments of Public Health Dentistry & Oral Pathology and Microbiology, Faculty of Dental Sciences, Krishna Institute of Medical Sciences Deemed to be University, Karad, Maharashtra, India.

Background: Oral cavity cancer is estimated to be the third most common malignancy after cancer of cervix and stomach in developing countries.

Objectives: The objective of this study is to investigate the relationship between smoking, alcoholic consumption, betel quid chewing, and OPMD in a prospective manner.

Materials And Methods: A descriptive, cross-sectional study was conducted among 35-55-year-old adults of Western Maharashtra, India.

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Introduction: The emergence of novel nanobiomedicine has transformed the management of various infectious as well as non-infectious diseases., a medicinal plant, revealed the presence of active secondary metabolites and biological potentials.

Objective: The present study was aimed to demonstrate the biosynthesis of silver nanoparticles using leaf extract (LE-AgNPs) and their biological properties, such as antioxidant, antibacterial and anticancer potential.

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Background: The Objective of this study was estimation of Temporomandibular joint dysfunction in oral cancer survivors.

Methods: The hundred patients with oral cancer who had undergone radiotherapy or chemotherapy were randomly selected as per inclusion criteria. Range of motion of temporomandibular joint(TMJ), visual analogue scale (VAS), Manual muscle testing (MMT), Auscultation test, Chvostek test and swelling over orofacial muscles were used as the  Outcome measures.

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Three-dimensional printing in maxillofacial surgery: A quantum leap in future.

Natl J Maxillofac Surg

August 2022

Department of Oral and Maxillofacial Surgery, Rural Dental College, Loni, Maharashtra, India.

Although application of three-dimensional (3D) printing in oral and maxillofacial surgery (OMFS) was first reported almost 30 years back, reduction in its manufacturing cost and availability of affordable 3D printing devices have popularized its use over the past few years. The 3D-printed objects include anatomical models, occlusal splints, drilling, or cutting guides and patient-specific implants (custom made plates and reconstruction devices). The anatomical model not only assists the surgeon in better understanding of the deformity or pathology but also aids in explaining the same to the patient and relatives.

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Estimation of Neural Tissue Mobility in Breast Cancer Survivors with Lymphedema.

Asian Pac J Cancer Prev

October 2022

Department of Musculoskeletal Sciences, Krishna College of Physiotherapy, Krishna Institute of Medical Sciences, Deemed to Be University, Karad, Maharashtra, India.

Background: Lymphedema in breast cancer survivors is a very common condition which progressively may lead to entrapment  neuropathy. In lymphedema there is accumulation of fluid due to removal of lymph nodes which causes stretching of nerve fibres within the skin, compression on top of the nerve bundle leading to nerve entrapment. This will increase the neural mechanosensitivity and functional impairment of shoulder as a protective neural response to movement or traction.

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Background: Dental remineralization is the process of transporting minerals from the surrounding environment (i.e., saliva and biofilm) into partially demineralized tooth structures.

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Background: Tuberculosis is the leading cause of death from a single infectious agent among the HIV-negative population and ranks first among the HIV-positive population. However, few studies have assessed tuberculosis trends in Brazil, Russia, India, China and South Africa (BRICS) or with an emphasis on HIV status. This study assesses the time trends of tuberculosis mortality across the BRICS with an emphasis on HIV status from 1990 to 2019.

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Statement Of Problem: The leaching of elements from long-term definitive prostheses, with saliva acting as an electrolyte, poses a biological concern. The approximate concentration in the biological samples that are considered clinically toxic ranges from 1 to 5000 nmol/L for Cr and Co, 1 to 200 nmol/L for Ni, and 1 to 20 nmol/L for Mo. While in vitro studies are available regarding the leaching of elements in artificial saliva, solutions containing protein, solutions of different pH, and different culture media, the in vivo effects of leaching in the biological sample with increasing time are unknown.

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An study to Compare Dental Laser with other Treatment Modalities on Biofilm Ablation from Implant and Tooth Surfaces.

J Pharm Bioallied Sci

July 2022

Department of Public Health Dentistry, MDS Public Health Dentistry, Mumbai, Maharashtra, India.

Background: Periodontal and peri-implant disorders are etiologically linked to bacterial biofilms. The researchers wanted to see how well the erbium-doped yttrium aluminum garnet (Er:YAG) laser removed bacterial biofilms along with attached epithelial cells (EC), gingival fibroblasts (GF), in addition to osteoblast-like cells (OC) dentin along with titanium surfaces compared to previous therapy methods.

Methodology: 3.

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