Sunshine and Sadness: A Case Report on Summer Season Depression.

Seasonal affective disorder (SAD) is typically associated with winter; however, its less common variant, summertime depression, presents with depressive episodes during the summer months. We report a case of a 46-year-old male patient with recurrent summertime depressive episodes characterized by low mood, fatigue, anhedonia, insomnia, and loss of appetite, each resolving with the onset of the winter season. Our patient's history of summertime depression aligned with the atypical SAD symptoms, including irritability and weight loss, commonly associated with non-seasonal depression.

Efficacy and safety of sublingual buprenorphine in managing acute postoperative pain - A systematic review.

Sublingual (SL) buprenorphine has been used as a modality of managing acute postoperative pain in many studies. This systematic review aimed to investigate the safety and efficacy of SL buprenorphine as an analgesic for various surgeries. After registering the protocol with PROSPERO, we searched PubMed, Cochrane Library, and Ovid databases with relevant keywords.

Effect of Multi-component Exercise Program on Body Composition and Physical, Emotional and Social well being in Breast Cancer Survivors.

Objective: The purpose of this research intended to determine the impact of an multi-component exercise program on body composition and physical, emotional and social well being (PWB, EWB,SWB) in breast cancer survivors (BCS).  Methods: One hundred and thirty two eight women with BC were enrolled in this research based on inclusion and exclusion criteria and were randomized into group A and B. Group A received breast cancer (BC) support group therapy whereas group B received multi-component exercise program.

Effect of Multi-component Exercise Program on Functional Performance in Breast Cancer Survivors.

Background: Breast surgery, radiation, chemotherapy and modified radical mastectomy (MRM) may cause long-term side effects such as decreased muscle strength, pulmonary function, cardio-respiratory fitness (CRF), altered body fat distribution and poor sleep quality. These short- and long-term repercussions have an enormous effect on physical functioning in this population. The goal of this research was to determine the effect of a multi-component exercise program on functional performance in breast cancer survivors.

Impact of Hypothyroidism in Pregnancy on Feto-Maternal Outcomes: A Prospective Observational Study.

Introduction Hypothyroidism represents an endocrine disorder marked by the insufficient production of hormones by the thyroid gland, with significant effects on bodily functions. Its occurrence during pregnancy is of particular concern due to its profound effects on both maternal and fetal health outcomes. Aim To study the impact of hypothyroidism in pregnancy and its correlation with feto-maternal outcomes.

Current Advances in Lipid-Based Drug Delivery Systems as Nanocarriers for the Management of Female Genital Tuberculosis.

Female genital tuberculosis (FGTB) arises from infection and can rarely be caused by or atypical mycobacteria. FGTB usually arises from tuberculosis (TB) that affects the lungs or other organs. The infection can enter the vaginal tract directly from abdominal TB or by hematogenous or lymphatic pathways.

Study of the Analgesic Activity of the Aqueous and Methanolic Extracts of Fresh Rhizome of Zingiber officinale in Wistar Rats.

Introduction The study was done to evaluate the analgesic activity of the aqueous and methanolic extracts of fresh rhizome of . The study objectives included evaluating and comparing the analgesic activity of both extracts at two different doses with that of the standard drug (aspirin) in Wistar rats using the rat tail-flick method. Method The study was conducted after receiving approval from the animal ethics committee.

Antimicrobial Resistance Profile of Enterococcal Isolates From Clinical Specimens at a Tertiary Care Hospital in Western Maharashtra, India.

Background , once benign intestinal flora, has transformed into formidable nosocomial pathogens as a result of the accelerated emergence of antibiotic resistance represents a major global health challenge, particularly within hospital settings. has grown more prevalent in nosocomial infections, such as urinary tract infections (UTIs), surgical site infections (SSIs) and bacteremia. The potential emergence of vancomycin-resistant (VRE) strains further complicates treatment choices for multi-drug resistant (MDR) infections.

Emerging Healthcare Threat Candida auris: A Prevalence Study From a Rural Tertiary Referral Centre in Western India.

Background has emerged as an important healthcare-associated pathogen that has high mortality rates. Additionally, this pathogen can cause nosocomial outbreaks. However, in comparison to the vast majority of the pathogenic species from the genus Candida, is difficult to treat and identify by using conventional therapeutic and diagnostic modalities.

Unlocking the Future: New Biologic Therapies for Rheumatoid Arthritis.

Rheumatoid arthritis (RA) is a chronic autoimmune disorder that leads to joint destruction and functional disability. Traditional treatments, including disease-modifying antirheumatic drugs (DMARDs), often fail, leaving many patients without remission. The advent of biologic therapies that target specific immune system components (e.

The Burden and Prevention of Human Papillomavirus (HPV) Infections and Cervical Cancer in India: A Literature Review.

Human papillomavirus (HPV) is a widespread viral infection affecting the reproductive tract and is associated with multiple types of cancer. It is a significant global health concern, with cervical cancer being one of the most common cancers affecting women worldwide. HPV infection has been found in both married and unmarried women.

Study of Coagulation Parameters in Gastrointestinal Malignancies.

Introduction  Gastrointestinal (GI) malignancies represent a diverse group of cancers affecting various parts of the digestive system. These malignancies encompass an important burden of cancer incidence and mortality globally, contributing to substantial morbidity and mortality worldwide. Studying the coagulation parameters of patients having GI malignancies is crucial for several reasons.

Effect of Lumbar Spinal Stabilization Exercises Along With Neural Tissue Mobilization on Pain and Spinal Dysfunction in Failed Back Surgery Syndrome.

Background Failed back surgery syndrome (FBSS) mainly involves back pain radiating to the lower limb after back-related surgeries. It can develop various complications around the operation site and its surrounding area. This study evaluates the effect of lumbar spinal stabilization exercises and neural tissue mobilization on pain and spinal dysfunction in FBSS.

Bacteriological Profile and Antibiogram Pattern of Wound Infection in a Tertiary Care Hospital.

Background and aim Wound infection constitutes a major barrier to healing and can have a harmful effect on the patient's quality of life and also on the healing rate of the wound. The widespread use of antibiotics, along with their extensive history of availability, has resulted in significant issues with resistant organisms contributing to morbidity and mortality. The study was conducted to determine the prevalence of bacterial species obtained from the wound sample and its antibiotic resistance pattern.

Theranostic Applications of Scaffolds in Current Biomedical Research.

Theranostics, a remarkable combination of diagnostics and therapeutics, has given rise to tissue/organ-format theranostic scaffolds that integrate targeted therapy and real-time disease monitoring. The scaffold is a 3D structuring template for cell or tissue attachment and growth. These scaffolds offer unprecedented opportunities for personalized medicine and hold great potential for revolutionizing healthcare.

A Comparative Study of Frontal and Cerebellar Lobe Volumes Between Patients With First-Episode Schizophrenia and Healthy Controls and Its Association With Psychopathology and Neurological Soft Signs in Patients.

Objectives Our study aimed to investigate the fronto-cerebellar volumes in both patients and controls, as well as explore their relationship with symptomatology. Our primary objectives were to compare the frontal and cerebellar lobe volumetric measurements between patients with first-episode schizophrenia (FES) and healthy controls and to assess the relationship of these volumes with psychopathology, cognition, and neurological soft signs in FES patients. The secondary objective was to explore the association of fronto-cerebellar lobe volumes with socio-demographic factors among patients and controls, as well as the duration of untreated illness (DUI) among patients.

Cellular stress response and neuroprotection of flavonoids in neurodegenerative diseases: Clinical insights into targeted therapy and molecular signaling pathways.

Neurodegenerative diseases (NDs) are caused by the gradual decline of neuronal structure and function, which presents significant challenges in treatment. Cellular stress responses significantly impact the pathophysiology of these disorders, often exacerbating neuronal damage. Plant-derived flavonoids have demonstrated potential as neuroprotective agents due to their potent anti-inflammatory, anti-apoptotic, and antioxidant properties.