Is Surgery for Congenital Heart Defects in Neonates, Infants, and Children More Challenging and Demanding Than Surgery for Acquired Heart Defects in Adults?

Pediatric cardiac surgery is a highly challenging medical subspecialty requiring technical precision, adaptability, and extensive multidisciplinary support. Unlike adult cardiac surgery, which often addresses standardized acquired conditions, surgery for congenital heart disease (CHD) in neonates, infants, and children involves unique anatomical and physiological complexities. These patients often need individualized surgical plans, and many benefit from staged interventions to accommodate growth.

A case report on comparison between PMCT and conventional autopsy approach in traumatic death.

In cases of traumatic death, precise injury evaluation is crucial for both legal and medical reasons. In the modern era, many scholarly articles recommend postmortem computed tomography (PMCT) instead of routine postmortem practices. This case report compares the findings of PMCT with those of conventional autopsy methods for assessing blunt traumatic injuries.

Addressing the Alarming Rise in Pediatric Cancer Prevalence in India: A Call to Action.

Background: Childhood cancer has become a pressing global concern, impacting over 200,000 children annually, and is projected to escalate to 21 million diagnoses by 2030. This article discusses the growing incidence of pediatric cancer in India, describes the unique obstacles it faces, and encompasses a strategy for solving this pressing problem.

Methods: We reviewed published scientific literature and available information on cancer control and prevention programs in India.

Movement Disorders after Dengue Virus Infection: A Scoping Review.

Movement disorders after dengue virus (DENV) infection have been increasingly recognized. We aimed to synthesize the clinical and paraclinical characteristics, treatment responses, and outcomes of these neurologic complications. We systematically reviewed PubMed, Embase, Scopus, and LILACS databases up to September 2023 following a published protocol.

Dr. Krishna Manohar Soman Rema: A Legacy of Innovation, Education, and Compassion in Pediatric Cardiac Surgery.

Dr. Krishna Manohar Soman Rema (SR) (1956-2022) was a pioneering congenital cardiac surgeon and an inspiring educator who dedicated his life to advancing pediatric cardiac care and mentoring the next generation of surgeons. Trained in cardiac surgery at the Sree Chitra Tirunal Institute for Medical Sciences and Technology in Kerala, he served as faculty there for 20 years, contributing significantly to the development of the Chitra Heart Valve.

Retraction: Corrective Efficacy of Calcaneal Lengthening Osteotomy for Planovalgus Deformity in Cerebral Palsy Patients.

[This retracts the article DOI: 10.7759/cureus.57092.

Fatal acute uterine inversion post-vaginal delivery: an autopsy-based case report.

Uterine inversion refers to the condition where the fundus is turned inside and positioned within the uterine cavity. Uterine inversion is a life-threatening and uncommon obstetric emergency that can be fatal because of postpartum hemorrhage and shock. Acute uterine inversion is the most common type, which occurs within 24 h of delivery and is usually associated with untrained birth attendants and a lack of knowledge of labor-inducing drugs.

Reimplantation of Thymus at the First Superior Cavo-Pulmonary Anastomosis and Its Outcome.

During bidirectional cavo-pulmonary anastomosis (bidirectional Glenn; BDG), the thymic tissue is often excised to facilitate the exposure of the superior vena cava and its junction with the innominate vein. Subsequently, it is discarded. Since the last two decades, the lead author (ST) has pursued anchoring the excised thymus in its position by suturing it to the opposite unexcised thymic lobe.

Importance of Urine Culture and Antibiotic Sensitivity for Improving Clinicians' Choice in Treating Urinary Tract Infections.

Background: The local antibiogram is essential to prevent the development of multidrug-resistant organisms. The aim of the study was to find out the synchronization of empirical antibiotics with the sensitivity pattern of the urine culture report and to study the differences in the organisms and sensitivity patterns in urinary tract infection (UTI) with and without other comorbidities.

Materials And Methods: UTI, diagnosed by a positive urine culture report of 300 consecutive patients above the age of 18, was studied retrospectively.

Indian Trial of Tranexamic acid in Spontaneous Intracerebral Hemorrhage study protocol.

Rationale: Early mortality in intracerebral hemorrhage (ICH) is due to hematoma volume (HV) expansion, and there are no effective treatments available other than reduction in blood pressure. Tranexamic acid (TXA) a hemostatic drug that is widely available and safe can be a cost-effective treatment for ICH, if proven efficacious.

Hypothesis: Administration of TXA in ICH patients when given within 4.

Progressive Supranuclear Palsy in India: Past, Present, and Future.

Progressive supranuclear palsy (PSP) has emerged as a key area of interest among researchers worldwide, including those in India, who have actively studied the disorder over the past several decades. This review meticulously explores the extensive range of Indian research on PSP up to the present and offers insights into both current initiatives and potential future directions for managing PSP within the region. Historical research contributions have spanned 80 publications from 1974 to 2023, encompassing diverse themes from clinical phenotyping and historical analysis to isolated investigative studies and therapeutic trials.

Graham-Little-Piccardi-Lassueur Syndrome with Mucosal Involvement: A Rare Case.

Graham-Little-Piccardi-Lassueur syndrome (GLPLS) is a type of lichen planopilaris. It mainly affects females aged 40-60 years. It is characterized by the triad of patchy cicatricial alopecia of the scalp, noncicatricial alopecia of the axilla and groin and a follicular spinous papule on the body, scalp, or both.

Prospective Observational Cohort Study of Tenecteplase: Results From the Indian Registry in Ischemic Stroke-Tenecteplase.

Background: Tenecteplase has been approved for acute ischemic stroke at a dose of 0.2 mg/kg by the Indian licensing authority. A registry to evaluate the safety of tenecteplase was mandated by the licensing authority.

A Global Bibliometric Analysis of the Top 100 Most Cited Articles on Early Thoracotomy and Decortication in Pleural Empyema.

Most pleural empyema cases are linked to pneumonia, a substantial fraction of patients present with empyema without any association to pneumonia. The occurrence of empyema caused by tuberculosis (TB) is increasing in regions where TB is prevalent. In May 2024, a bibliometric analysis was conducted involving the screening of 7,620 articles sourced from Google Scholar.

Evaluation of Various Retention Protocols in Sustaining Treatment Outcomes Following Orthodontic Therapy.

Background: Orthodontic therapy aims at achieving stable treatment outcomes by ensuring retention of corrected tooth positions. Various retention protocols have been proposed, but their efficacy in sustaining treatment outcomes remains unclear.

Materials And Methods: This study evaluated the effectiveness of different retention protocols in maintaining treatment outcomes following orthodontic therapy.

The Study of Correlation between Symptoms of Gastritis and Endoscopic Biopsy.

Background: Gastritis is a very common disorder that is widely distributed worldwide, representing one of the most prevalent pathological entities in gastroenterology and digestive endoscopy. This study aims to analyse the correlation between the endoscopic findings and the symptoms of gastritis. Upper gastro-intestinal (UGI) endoscopy is a widely used investigation for a variety of UGI symptoms namely dysphagia, dyspepsia, abdominal pain, etc.

Loop Diuretics Unique Mechanism of Action.

Loop diuretics, including torsemide, furosemide, bumetanide, and piretanide, act by inhibiting the sodium-potassium-chloride (Na/K/2Cl) cotransporter in the thick ascending limb of the loop of Henle within the nephron. This mechanism is pivotal in managing fluid retention associated with conditions such as heart failure, cirrhosis, chronic kidney disease, and hypertension. A comprehensive understanding of how these diuretics uniquely target this transporter provides crucial insights into effectively addressing fluid overload across diverse clinical conditions.

Biofilm mediated integrin activation and directing acceleration of colorectal cancer.

Bacterial biofilm plays a vital role in influencing several diseases, infections, metabolic pathways and communication channels. Biofilm influence over colorectal cancer (CRC) has been a booming area of research interest. The virulence factors of bacterial pathogen have a high tendency to induce metabolic pathway to accelerate CRC.

Levodopa Equivalent Daily Dosage: Geographical Variations and Real-Life Modules in Parkinson's Disease.

Background: The Levodopa Equivalent Daily Dosage (LEDD) calculation algorithms help in capturing and harmonization of Parkinson's Disease (PD) therapies. Analyzing these updates is essential for validating their effectiveness.

Objective: To assess updated LEDD conversion factors in capturing the newer therapies in PD and therapy modules in different geographical cohorts.