Comparative Analysis of Effective Lens Position and Refractive Outcomes in Scleral-Fixated versus Intracapsular Intraocular Lenses.

Purpose: To evaluate the outcomes of scleral-fixated intraocular lenses (IOLs) implanted using either Yamane technique or Gore-Tex suture fixation, in comparison to intracapsular lens fixation, and to assess the efficacy of various lens formulas in achieving predicted refractive targets.

Patients And Methods: This study included 45 eyes from 44 patients with scleral-fixated IOLs, comprising 37 Yamane eyes and 8 Gore-Tex eyes. Preoperative refractive predictions from various formulae were compared with final postoperative refraction.

TEMPORARY AMNIOTIC MEMBRANE GRAFT PLACEMENT FOR TREATMENT OF REFRACTORY MACULAR HOLES.

Purpose: To report two patient cases demonstrating the management of refractory macular holes through the application of temporary thin amniotic membrane grafts, followed by subsequent graft removal upon achieving hole closure.

Methods: Comprehensive chart and literature review was conducted utilizing the PubMed database.

Results: We describe two patients who underwent repeat pars plana vitrectomy for treatment of refractory macular holes.

Retinal detachment in a pediatric patient with enhanced S-cone syndrome.

Enhanced S-cone syndrome (ESCS), also known as Goldmann-Favre syndrome, is a retinal degeneration that presents in childhood and leads to progressive nyctalopia and visual field loss. In advanced cases, this degeneration can result in loss of central visual acuity. We describe the case of a 15-year-old boy with ESCS who presented with retinal detachment, a rare complication.

Intraocular Lens Formula Comparison of Flanged Intrascleral Intraocular Lens Fixation with Double Needle Technique.

Purpose: To analyze visual outcomes and accuracy of intraocular lens (IOL) calculation formulas in predicting postoperative outcomes in patients undergoing flanged intrascleral IOL fixation.

Design: Case Series.

Subjects: Twenty-three patients who had undergone secondary IOL placement using flanged intrascleral fixation technique.

Autosomal Dominant Vitreoretinochoroidopathy With a Novel BEST1 Mutation and a Review of Reported Mutations.

Here we describe a patient with atypical presentation of autosomal dominant vitreoretinochoroidopathy (ADVIRC) with a novel missense mutation in BEST1 gene and briefly review reported ADVIRC-associated genetic mutations. The patient is a 71-year-old African American female who presented with progressively worsening blurry vision bilaterally over the course of 40 years, with significant deterioration in both peripheral and central vision in the past five years. Her anterior segment exam was unremarkable.

Pleiotropy of a Stickler syndrome genotype.

Purpose: To report a case of pleiotropy in the gene typically associated with Stickler Syndrome Type 1.

Observations: A patient with a confirmed mutation of the gene presented with an isolated retinitis pigmentosa phenotype.

Conclusions: The mutated gene in Stickler Syndrome Type 1 represents a site of pleiotropy, highlighting a change in phenotype across the same genotype potentially due to tissue alternative splicing.

Nonsurgical management of photoaversive ocular and systemic loiasis in Michigan.

Ocular loasis refers to ocular conditions such as pain and redness caused by the movement of the nematode through the subconjuctival space of the eye. It is a tropical disease that is very rarely seen in North America. We report the case of a 32-year-old male who was recently diagnosed with ocular loasis in the Midwestern region of the United States.

Quantifying vitreous inflammation in uveitis: an optical coherence tomography prospective study.

Objective: To quantify vitreous inflammation in a uveitis cohort using optical coherence tomography and correlate findings to gold-standard Nussenblatt scores.

Design: Prospective cohort study.

Participants: 36 eyes from 19 patients primarily with pan uveitis.

Pediatric conjunctival lymphoma associated with oral carbamazepine use.

Purpose: To report a case of a pediatric patient diagnosed with conjunctival lymphoma associated with oral carbamazepine use.

Observation: An 11-year-old boy who presented with 5-month history of a small nasal conjunctival mass in the left eye that failed therapy with topical corticosteroids. Upon excision and molecular analysis, diagnosis of Follicular Lymphoma was favored.

Lipotoxicity augments glucotoxicity-induced mitochondrial damage in the development of diabetic retinopathy.

Purpose: Although hyperglycemia is the main instigator in the development of diabetic retinopathy, dyslipidemia is also considered to play an important role. In the pathogenesis of diabetic retinopathy, cytosolic NADPH oxidase 2 (Nox2) is activated before retinal mitochondria are damaged. Our aim was to investigate the effect of lipids in the development of diabetic retinopathy.

Bilateral panuveitis in a patient on vemurafenib BRAF inhibitor therapy for stage IV melanoma.

Purpose: To describe a case of recurrent, bilateral panuveitis caused by the BRAF proto-oncogene inhibitor vemurafenib.

Methods: Case report.

Results: A 25-year-old woman developed bilateral panuveitis and macular edema after initiating treatment with the BRAF enzyme inhibitor vemurafenib for stage IV cutaneous melanoma.

A prospective study assessing the utility of Cogan's lid twitch sign in patients with isolated unilateral or bilateral ptosis.

Objective: Cogan's lid twitch is thought to suggest myasthenia gravis in patients with unexplained ptosis. The validity of this clinical test has not been established. We conducted a prospective study to ascertain the sensitivity and specificity of this finding.

Choroidal melanoma with massive extrascleral extension in a young black man.

The reported incidence of choroidal melanoma is low among the general population and is especially low among blacks. Choroidal melanoma is seen most commonly in whites in the sixth to seventh decades. The tumor is complicated by orbital invasion in only a small percentage of cases.

Ischemic pituitary apoplexy associated with the lupus anticoagulant.

Purpose: To report a case of ischemic pituitary apoplexy secondary to a hypercoagulable state following elective orthopedic surgery.

Design: Observational case report.

Methods: A 48-year-old Caucasian man underwent an uneventful, left-sided total hip replacement and corrective osteotomy of the proximal femur.