3 results match your criteria: "Krasnoyarsk branch of the «National Research Center for Hematology» Department of Health.[Affiliation]"
Article Synopsis
- The study explores the simultaneous measurement of five specific mRNA genes (WT1, BAALC, EVI1, PRAME, HMGA2) in whole blood samples as a potential diagnostic marker for acute leukemia, noting that traditional methods require isolation of cells first.
- Researchers analyzed 127 blood samples from confirmed acute leukemia patients and a comparison group of 87 patients without blood cancers to assess mRNA levels using multiplex PCR techniques.
- Results showed significant differences in mRNA expression levels, with high levels of WT1 found in most leukemia patients, and variations for BAALC, PRAME, and HMGA2 among different leukemia subtypes compared to the control group.
Abnormal mRNAs of the hybrid BCR-ABL gene in the majority of cases initiate the synthesis of proteins with a mass of 210 kDa (p210), 190 kDa (p190), and 230 kDa (p230). Expression of the p210 variant is most common in CML (95% of cases), while the p190 and p230 variants are less common (1-4%). On the contrary, p190 predominates in ALL.
View Article and Find Full Text PDF[Investigation of miR-155 level in the blood of patients with chronic lymphocytic leukemia and Ph-negative myeloproliferative neoplasms.].
Klin Lab Diagn
July 2020
Krasnoyarsk branch of the «National Research Center for Hematology» Department of Health, Krasnoyarsk, Russian Federation.
MiR-155 is involved in various physiological processes in the cell, including hematopoiesis, immunity, inflammation and differentiation. Increased expression of miR-155 is observed in many malignant diseases, including lymphomas, acute myeloid leukemia and CLL. However, a comparative study of the miR-155 expression in the blood leukocytes in patients with chronic myeloid and lymphoproliferative diseases has not yet been carried out.
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