Systemic Mechanisms of Ionic Regulation in Carcinogenesis.

Cancer is a complex disease characterized by uncontrolled cell proliferation at various levels, leading to tumor growth and spread. This review focuses on the role of ion homeostasis in cancer progression. It describes a model of ion-mediated regulation in both normal and cancerous cell proliferation.

Challenges in Liquid-Phase Exfoliation of Non-van der Waals CrS.

Two-dimensional (2D) chromium(III) sulfide has recently attracted increased attention from researchers due to its interesting electronic and magnetic properties and has great potential for application in spintronics and optoelectronics to create sensitive photodetectors. However, the synthesis of 2D CrS crystals is still a challenging task. At present, the mainly used method is vapor deposition, which is a poorly scalable, time-consuming, and expensive process.

Using Computer Modeling and Experimental Methods to Screen for Aptamers That Bind to the VV-GMCSF-LACT Virus.

Oncolytic virotherapy is a promising approach for cancer treatment. However, when introduced into the body, the virus provokes the production of virus-neutralizing antibodies, which can reduce its antitumor effect. To shield viruses from the immune system, aptamers that can cover the membrane of the viral particle are used.

A new material built with alternating Cu sulfide and (Al,Mg) hydroxide molecular sheets: hydrothermal synthesis and selected characteristics.

Two-dimensional materials with new physical phenomena are gaining popularity due to their unique properties. In recent years, a new family of layered compounds inspired by the minerals valleriite and tochilinite which are composed of alternating quasi-atomic sheets of transition metal chalcogenides (sulfides and selenides of Fe, Fe-Cu and other metals) and hydroxides of Mg, Al, Fe, Li, ., assembled electrostatic interaction, has arisen as a new synthetic platform for 2D materials.

Inhibition of M2 tumor-associated macrophages polarization by modulating the Wnt/β-catenin pathway as a possible liver cancer therapy method.

The problem of liver cancer is becoming increasingly important due to the epidemic of metabolic diseases and persistent high alcohol consumption. This determines great attention to the development and improvement of methods for early diagnosis and treatment of liver cancer. Huang presented a study in the , in which they showed that the use of the traditional Chinese medicine (CB) can suppress tumor growth in mice by inhibiting M2 tumor-associated macrophages (TAM) through modulating the activity of the Wnt/β-catenin pathway.

Tailoring of Ultrasmall NiMnO Nanoparticles: Optimizing Synthesis Conditions and Solvent Effects.

Nickel manganese oxide (NiMnO) combines magnetic and dielectric properties, making it a promising material for sensor and supercapacitor applications, as well as for catalytic water splitting. The efficiency of its utilization is notably influenced by particle size. In this study, we investigate the influence of thermal treatment parameters on the phase composition of products from alkali co-precipitation of nickel and manganese (II) ions and identify optimal conditions for synthesizing phase-pure nickel manganese oxide.

Novel SOI-Biosensor Topology for the Detection of an Acute Myocardial Infarction Marker - Troponin I.

Unlabelled: A biosensor based on field-effect transistors on silicon-on-insulator structures (SOI-biosensor) is a high-potential device for detection of biological molecules, for instance, such as troponin I; the biosensor allows conducting label-free real-time analysis. is the development of SOI-biosensor design for detection of acute myocardial infarction marker - troponin I. A notable feature of this design was the integration of two grounding electrodes directly onto the biosensor surface, which effectively nullified the static potential of the liquid sample and minimized physical breakdowns of biosensor elements.

Unleashing the antitumor power of cyclophosphamide by arabinogalactan and aptamer conjugation.

Cyclophosphamide (CPA) (2-oxo-2-di(β-chloroethyl)amino tetrahydro-2,1,3-phosphoxazine) is an alkylating cytostatic compound with a broad spectrum of antitumor activity. Despite its efficacy, the clinical application of CPA is hindered by the significant occurrence of adverse side effects. To address these limitations, a promising approach involves the mechanochemical treatment of CPA with arabinogalactan (AG) to facilitate the dispersion of the drug within the AG matrix.

In Vitro Hemocompatibility of Arabinogalactan, Betulin, and Betulin Derivatives.

The hemocompatibility of arabinogalactan, betulin and its derivatives was evaluated in vitro and samples suitable for creation of nanostructures or materials in contact with blood were selected. The prospects of arabinogalactan as a component of the construct (nanostructure) for drug delivery are due to the fact that it did not affect blood/plasma coagulation (at concentrations of 0.0033-3.

Parasites of the liver: A global problem?

Parasitic liver diseases can be caused by trematodes, cestodes, nematodes, and protozoa. This pathology is significant because millions of people in different parts of the world have liver parasites, which can manifest themselves in the development of inflammation, liver cysts, cholecystitis, cholelithiasis, pancreatitis and liver cirrhosis that are often threatening their lives. The International Agency for Research on Cancer considers three species of trematodes, , and , to be carcinogens.

Visualization of Brain Tumors with Infrared-Labeled Aptamers for Fluorescence-Guided Surgery.

Gliomas remain challenging brain tumors to treat due to their infiltrative nature. Accurately identifying tumor boundaries during surgery is crucial for successful resection. This study introduces an innovative intraoperative visualization method utilizing surgical fluorescence microscopy to precisely locate tumor cell dissemination.

Comparative Proteomic Profiling of Blood Plasma Revealed Marker Proteins Involved in Temporal Lobe Epilepsy.

Temporal lobe epilepsy has various origins, involving or not involving structural changes in brain tissue. The mechanisms of epileptogenesis are associated with cell regulation and signaling disruptions expressed in varied levels of proteins. The blood plasma proteomic profiling of temporal lobe epilepsy patients (including magnetic resonance imaging (MRI)-positive and MRI-negative ones) and healthy volunteers using mass spectrometry and label-free quantification revealed a list of differently expressed proteins.

Fauna and Ecology of Macromycetes (Basidiomycota) in the Arctic Tree and Shrub Ecosystems of Central Siberia.

The research was aimed at studying the taxonomic diversity, habitat specialization, and trophic characteristics of mycobiota, including Basidiomycota, in the northern ecosystems of the Krasnoyarsk Krai (Central Siberia) near Norilsk. Larch forests and woodlands in the Siberian permafrost zone are distinctive and Basidiomycota, as a component of these ecosystems, plays an essential role in their functioning. Currently, there is a paucity of information about this group in Arctic ecosystems, both in terms of floristic and ecological aspects.

The Preparation and Contact Drying Performance of Encapsulated Microspherical Composite Sorbents Based on Fly Ash Cenospheres.

Sorption technologies are essential for various industries because they provide product quality and process efficiency. New encapsulated microspherical composite sorbents have been developed for resource-saving contact drying of thermolabile materials, particularly grain and seeds of crops. Magnesium sulfate, known for its high water capacity, fast sorption kinetics, and easy regeneration, was used as an active moisture sorption component.

The use of bioluminescent enzyme bioassay for the analysis of human saliva: Advantages and disadvantages.

The purpose of the work was to find optimal conditions for bioluminescent enzymatic analysis of saliva (based on the use of NADH:FMN oxidoreductase + luciferase) and then to determine the biological effect of using bioluminescence assay of saliva to study the physiological state of the body under normal and pathological conditions. The saliva of snowboarders and students were studied in the "rest-training" model. The saliva of patients diagnosed with acute pharyngitis was examined in the "sick-healthy" model.

Correction: Volova et al. Laser Processing of Polymer Films Fabricated from PHAs Differing in Their Monomer Composition. 2021, , 1553.

In the original publication [...

Effects of iron oxide nanoparticles on the gene expression profiles of cerebral endotheliocytes and astrocytes.

Iron oxide nanoparticles (IONPs) are considered as the most biocompatible magnetic materials suitable for biomedical applications. Nevertheless, there are many evidences of their toxicity for living organisms and partially neurotoxicity. The central nervous system is protected from undesirable substances circulating in the bloodstream by the blood-brain barrier (BBB).

Association of Blood NK Cell Phenotype with the Severity of Liver Fibrosis in Patients with Chronic Viral Hepatitis C with Genotype 1 or 3.

Background: NK cells phenotype and functional state in different genotypes of chronic viral hepatitis C (CVHC), depending on liver fibrosis severity, have not been sufficiently studied, which limits the possibilities for the development of pathology therapy.

Methods: The CVHC diagnosis was based on the EASL recommendations (2018). Clinical examination with liver elastometry was performed in 297 patients with genotype 1 and in 231 patients with genotype 3 CVHC.

Fatty Acid Profile of Juvenile Arctic Char (Salvelinus alpinus Complex) from Natural Ecosystems and Aquaculture.

Significant differences in the fatty acid composition of the muscle tissue of juvenile Arctic char Salvelinus alpinus (Linnaeus, 1758) from the natural habitat (Lake Sobach'e) and aquaculture, as well as juveniles of the anadromous form of char (malma) Salvelinus malma (Walbaum, 1792) from the Avacha River were found. The observed differences between aquaculture and wild juvenile char were associated with different food sources. The muscle tissue of juvenile char from natural habitat was characterized by significantly higher levels of fatty acids-biomarkers of diatoms, as well as biomarkers of marine copepods in the anadromous form.

[Assessment of the phenotypic composition of lymphocytes, immunoglobulins and their relationships in patients with chronic rinosinusitis].

Objective: The study of the population and subpopulation content of lymphocytes and immunoglobulins and their associations in IgE-mediated CRS relative to other CRS and the control group.

Material And Methods: 23 patients with IgE-mediated chronic rhinusinusitis and 67 patients with normal IgE blood levels were examined. For analysis, flow cytometry (Cytomics FC500, Beckman Coulter, USA), using monoclonal antibodies CD3, CD4, CD8, CD16, CD19 and enzyme immunoassay (Thermo Scientific Multiskan FC, Thermo Fisher Scientific, USA), using IgA, IgM, IgE and IgG in serum, statistical processing was performed using Statistica 7.

Particulate matter from water moss of a large Siberian river: Morphometric, mineral, elemental and radionuclide composition.

Particulate matter trapped by tufts of water moss Fontinalis antipyretica inhabiting fast flowing waters of the Yenisei River (Siberia, Russia) contaminated with artificial radionuclides has been studied as a potential monitor of radioactive releases to the river. Particulate matter, which was removed from wet tufts of water moss of the Yenisei by rinsing them in water, constituted at least 38% of bulk dry weight of the moss biomass sample and was similar in the contents of chemical elements, minerals, organic matter, and artificial radionuclides to bottom sediments of the Yenisei. Considerable bulk percentages of artificial radionuclides in the sample of water moss, 77% of Cs, 44% of Co, 41% of Eu, 55% of Eu, 66% of Am, and 34-36% of plutonium were associated with extracellular particles.

Metal Chalcogenide-Hydroxide Hybrids as an Emerging Family of Two-Dimensional Heterolayered Materials: An Early Review.

Two-dimensional (2D) materials and phenomena attract huge attention in modern science. Herein, we introduce a family of layered materials inspired by the minerals valleriite and tochilinite, which are composed of alternating "incompatible", and often incommensurate, quasi-atomic sheets of transition metal chalcogenide (sulfides and selenides of Fe, Fe-Cu and other metals) and hydroxide of Mg, Al, Fe, Li, etc., stacked via electrostatic interaction rather than van der Waals forces.