Application of a 3D-Printed Part with Conformal Cooling in High-Pressure Die Casting Mould and Evaluation of Stress State During Exploitation.

The article addresses stress formation in the structural 3D-printed elements of a high-pressure die casting die mould used for production of aluminum castings. The 3D-printed elements with conformal cooling are manufactured of 18Ni300 powder. Initial numerical calculations were performed on a test die mould made of standard steel X40CrMoV5 to determine temperature distribution and stress state, providing a baseline for comparing 3D-printed 18Ni300 parts.

One Change, Many Benefits: A Glycine-Modified Bacteriochlorin with NIR Absorption and a Type I Photochemical Mechanism for Versatile Photodynamic Therapy.

Difluorinated sulfonamide porphyrin (FPGly) and bacteriochlorin (FBGly), modified by glycine residues, were synthesized and evaluated for photodynamic therapy (PDT). F₂PGly exhibits superior stability and singlet oxygen generation efficiency but features a low-intensity band in the red range (λ = 639 nm). In contrast, FBGly shows a favorable, red-shifted absorption spectrum (λ = 746 nm) that aligns well with phototherapeutic window, facilitating deeper tissue penetration.

Gradient Titanium Alloy with Bioactive Hydroxyapatite Porous Structures for Potential Biomedical Applications.

Hard bone disease is a clinical problem affecting more than 20 million people annually worldwide, with significant health, social, and economic consequences. For successful integration of any implant, the key aspects are bone regeneration, osseointegration at the bone-implant interface, and the mitigation of inflammation. The purpose of this research work is to demonstrate an innovative material system and method of biomaterial preparation for regenerative medicine.

Development of selective ssDNA micro-probe for PD1 detection as a novel strategy for cancer imaging.

Programmed death receptor 1, PD1, modulates the function of immune cells by providing inhibitory signals and constitutes the marker of immune exhaustion. Monitoring the level of PD1 promises a useful diagnostic approach in autoimmune diseases and cancer. Here we describe the development of an ssDNA aptamer-based molecular probe capable of specific recognition of human PD1 receptor.

Pattern Recognition in the Processing of Electromyographic Signals for Selected Expressions of Polish Sign Language.

Gesture recognition has become a significant part of human-machine interaction, particularly when verbal interaction is not feasible. The rapid development of biomedical sensing and machine learning algorithms, including electromyography (EMG) and convolutional neural networks (CNNs), has enabled the interpretation of sign languages, including the Polish Sign Language, based on EMG signals. The objective was to classify the game control gestures and Polish Sign Language gestures recorded specifically for this study using two different data acquisition systems: BIOPAC MP36 and MyoWare 2.

Application of X-Ray Computed Tomography to Identify Defects in Lost Wax Ceramic Moulds for Precision Casting of Turbine Blades.

This article presents the results of testing the suitability of X-ray computed tomography for the quality control of the casting moulds used for producing turbine blades. The research was focused on the analysis of cross-sectional images, spatial models and the porosity of moulds using a Phoenix L 450 microtomograph. The research material consisted of samples from three mixtures of ceramic materials and binders intended for producing casting moulds using the lost wax method.

Machine Learning-Based Gesture Recognition Glove: Design and Implementation.

In the evolving field of human-computer interaction (HCI), gesture recognition has emerged as a critical focus, with smart gloves equipped with sensors playing one of the most important roles. Despite the significance of dynamic gesture recognition, most research on data gloves has concentrated on static gestures, with only a small percentage addressing dynamic gestures or both. This study explores the development of a low-cost smart glove prototype designed to capture and classify dynamic hand gestures for game control and presents a prototype of data gloves equipped with five flex sensors, five force sensors, and one inertial measurement unit (IMU) sensor.

Better in the Near Infrared: Sulfonamide Perfluorinated-Phenyl Photosensitizers for Improved Simultaneous Targeted Photodynamic Therapy and Real-Time Fluorescence Imaging.

Tetraphenyloporphyrin derivatives are a useful scaffold for developing new pharmaceuticals for photodynamic therapy (PDT) and the photodiagnosis (PD) of cancer. We synthesized new sulfonamide fluorinated porphyrin derivatives and investigated their potential as photosensitizers and real-time bioimaging agents for cancer. We found that 5,10,15,20-tetrakis-[2',3',5',6'-tetrafluoro-4'-methanesulfamidyl)phenyl]bacteriochlorin () has intense absorption and fluorescence in the near-infrared, efficiently generates singlet oxygen and hydroxyl radicals, has low toxicity in the dark, and high phototoxicity.

Raman imaging unveils heme uptake in endothelial cells.

Heme released from damaged and senescent red blood cells (RBCs) may contribute to oxidant-mediated cell injury. One of the recently investigated physiological processes, essential in preventing the inflammatory impact of labile heme, is its uptake from the bloodstream by endothelial cells (ECs). In this study, we investigated heme uptake by ECs starting from the model studies on the in vitro cellular level, through the endothelium layer on the ex vivo murine aortic tissues.

Multivariate analysis of the kinematics of an upper limb rehabilitation robot.

The purpose of this work is to present a multivariate analysis of the kinematics of an upper limb rehabilitation robot. Comparing multiple concepts of kinematic chains makes it possible to identify advantages and disadvantages and, as a consequence, choosing the optimal solution to create a physical device. Such actions shall contribute towards automation of the rehabilitation process, bringing benefits to both therapists and patients in comparison with conventional rehabilitation.

Efficient and Selective, In Vitro and In Vivo, Antimicrobial Photodynamic Therapy with a Dicationic Chlorin in Combination with KI.

Various cationic photosensitizers employed in antimicrobial photodynamic therapy (aPDT) have the ability to photoinactivate planktonic bacteria under conditions of low phototoxicity to mammalian cells and without generating antimicrobial resistance (AMR). However, the photoinactivation of biofilms requires orders-of-magnitude higher photosensitizer concentrations, which become toxic to host cells. Remarkably, the bactericidal effect of a dicationic di-imidazolyl chlorin toward planktonic and was observed in this work for concentrations below 400 nM under illumination at 660 nm and below 50 μM for the corresponding biofilms.

Evaluation of the use of an antigravity device in leveling functional inequalities of the lower limbs and inhibiting the progression of idiopathic scoliosis.

Background: The conservative treatment of idiopathic scoliosis (IS) may be enhanced through a combination of specialized physiotherapy, bracing, and the utilization of assistive devices.

Objectives: This study aims to evaluate the efficacy of the GraviSpine device in supporting the conservative treatment of IS in children.

Material And Methods: A cohort of 142 patients, aged 10-17 years with an average age of 12.

An Innovative Method for the Conservative Treatment of Idiopathic Scoliosis Using the GraviSpine Device According to the Concept of Spinal Reflex Balance.

Conservative treatment of idiopathic scoliosis is more effective as a result of early diagnosis in conjunction with the use of specific physiotherapy and bracing techniques. Our aim was to investigate the effectiveness of specific physiotherapy developed according to the concept of spinal reflex balance using the GraviSpine device. This study is a retrospective analysis of prospectively collected data.

Machine Learning Methods for the Analysis of the Patch-Clamp Signals.

Patch-clamp technique provides a unique possibility to record the ion channels' activity. This method enables tracking the changes in their functional states at controlled conditions on a real-time scale. Kinetic parameters evaluated for the patch-clamp signals form the fundamentals of electrophysiological characteristics of the channel functioning.

Crystal Clear: Metal-Organic Frameworks Pioneering the Path to Future Drug Detox.

The growing number of acute drug abuse overdoses demands the development of innovative detoxification strategies for emergency purposes. In this study, an innovative approach for the application of porous Zr-based metal-organic frameworks for the treatment of acute overdoses of popular drugs of abuse including amphetamine, methamphetamine, cocaine, and MDMA is presented. A comprehensive approach determining the efficacy and the kinetics of drug removal, considering dosage, adsorption time, and adsorption mechanisms, was tested and corroborated with density functional theory (DFT) modeling.

Decision Support Tool in the Selection of Powder for 3D Printing.

The work presents a tool enabling the selection of powder for 3D printing. The project focused on three types of powders, such as steel, nickel- and cobalt-based and aluminum-based. An important aspect during the research was the possibility of obtaining the mechanical parameters.

The Effectiveness of Early Rehabilitation in Limiting the Progression of Idiopathic Scoliosis.

The purpose of this study was to assess specific rehabilitation methods' effectiveness in early idiopathic scoliosis (IS) development, focusing on lower limb functional inequality's role in scoliosis progression. : This study comprised 812 patients aged 6-16 years at risk of developing idiopathic scoliosis (IS). The mean (SD) age was 10.

High-Temperature Reactive Wetting of Natural Quartz by Liquid Magnesium.

High-temperature wetting of natural, high-purity quartz (SiO) and liquid magnesium (Mg) was investigated at temperatures between 973 and 1273 K. Sessile drop experiments using the capillary purification (CP) procedure were carried out under an Ar gas atmosphere (N6.0), eliminating the native oxide layer on the surface of Mg melt.

Electrochemical Assays for the Determination of Antidiabetic Drugs-A Review.

This article presents the current state of knowledge regarding electrochemical methods for determining the active substances within drugs that are used in the treatment of type 1 and type 2 diabetes. Electrochemical methods of analysis, due to their sensitivity and easiness, are a great alternative to other, usually more expensive analytical assays. The determination of active substances mentioned in this review is based on oxidation or reduction processes on the surface of the working electrode.

Deposition of NiAl/AlNi(CrB) Coatings from Ni, Al and CrB Powders Using Mechanical Synthesis in Planetary Ball Mill.

Interest in composite thick coatings with an intermetallic matrix stimulates the development of new deposition techniques like the co-milling of pre-alloyed NiAl powder with platelet-shaped substrates. Obtained coatings were up to several micrometers thick as cold-welding of intermetallic particles was effective only at the start of this process, while later, chipping prevailed over added material. The present experiment covered the co-milling in the planetary ball mill of Ni and Al elemental powders (1:1 molar ratio) with AISI 304 steel platelets for 32 h at 300 rpm.

Surface-enhanced Raman scattering (SERS) and tip-enhanced Raman scattering (TERS) in label-free characterization of erythrocyte membranes and extracellular vesicles at the nano-scale and molecular level.

The manuscript presents the potential of surface-enhanced Raman spectroscopy (SERS) and tip-enhanced Raman spectroscopy (TERS) for label-free characterization of extracellular microvesicles (EVs) and their isolated membranes derived from red blood cells (RBCs) at the nanoscale and at the single-molecule level, providing detection of a few individual amino acids, protein and lipid membrane compartments. The study shows future directions for research, such as investigating the use of the mentioned techniques for the detection and diagnosis of diseases. We demonstrate that SERS and TERS are powerful techniques for identifying the biochemical composition of EVs and their membranes, allowing the detection of small molecules, lipids, and proteins.

Analysis of the Possibility of Using Selected Tools and Algorithms in the Classification and Recognition of Type of Microstructure.

The aim of this research was to develop a solution based on existing methods and tools that would allow the automatic classification of selected images of cast iron microstructures. As part of the work, solutions based on artificial intelligence were tested and modified. Their task is to assign a specific class in the analyzed microstructure images.

Improvement in Abrasive Wear Resistance of Metal Matrix Composites Used for Diamond-Impregnated Tools by Heat Treatment.

This work presents the possibilities of producing a substitute for a commercial matrix material for sintered metal-diamond tools which is characterized by increased tribological properties required in machining natural stones and concrete. In this study, the improvement in wear behavior of sintered pre-alloyed matrix caused by a thermal treatment was investigated. Several mixtures made of commercially available powders were homogenized by ball milling and consolidated at 900 °C using the spark plasma sintering (SPS) method.