8 results match your criteria: "Korean German Institute of Technology[Affiliation]"
Sulfonanilide Derivatives in Identifying Novel Aromatase Inhibitors by Applying Docking, Virtual Screening, and MD Simulations Studies.
Biomed Res Int
August 2018
Division of Applied Life Science (BK21 Plus), Plant Molecular Biology and Biotechnology Research Center (PMBBRC), Systems and Synthetic Agrobiotech Center (SSAC), Research Institute of Natural Science (RINS), Gyeongsang National University (GNU), 501 Jinju-daero, Jinju 52828, Republic of Korea.
Breast cancer is one of the leading causes of death noticed in women across the world. Of late the most successful treatments rendered are the use of aromatase inhibitors (AIs). In the current study, a two-way approach for the identification of novel leads has been adapted.
View Article and Find Full Text PDFQSAR modeling to design selective histone deacetylase 8 (HDAC8) inhibitors.
Arch Pharm Res
October 2016
Department of Biochemistry, Division of Applied Life Science (BK21 Plus Program), Systems and Synthetic Agrobiotech Center (SSAC), Plant Molecular Biology and Biotechnology Research Center (PMBBRC), Research Institute of Natural Science (RINS), Gyeongsang National University, Jinju, Republic of Korea.
Article Synopsis
- HDAC8 inhibitors are emerging as promising treatments for cancer, leading this study to explore potential chemical structures that can selectively inhibit histone deacetylase 8 (HDAC8) using computational methods.
- The researchers developed advanced models for predicting HDAC8 inhibitors through non-linear QSAR methods and validated these models with high accuracy and correlation coefficients.
- Ultimately, this study identified two new chemical compounds for further biological testing, showcasing a valuable computational approach that could benefit drug design for other targets as well.
Molecular interactions of UvrB protein and DNA from Helicobacter pylori: Insight into a molecular modeling approach.
Comput Biol Med
August 2016
Division of Applied Life Science (BK21 Plus), Systems and Synthetic Agrobiotech Center (SSAC), Plant Molecular Biology and Biotechnology Research Center (PMBBRC), Research Institute of Natural Science (RINS), Gyeongsang National University (GNU), 501 Jinju-daero, Jinju 52828, Republic of Korea. Electronic address:
Article Synopsis
- * The UvrB protein is crucial for the DNA repair process in H. pylori, as it helps recognize and fix damaged DNA through multi-enzyme interactions.
- * Molecular modeling studies show that the Y96A mutation in UvrB reduces its binding to DNA, and comparing the stability of wild-type and mutant protein-DNA complexes suggests that understanding these interactions could aid in developing inhibitors to combat H. pylori infections.
Novel chemical scaffolds of the tumor marker AKR1B10 inhibitors discovered by 3D QSAR pharmacophore modeling.
Acta Pharmacol Sin
August 2015
Division of Applied Life Science (BK21 Plus Program), Systems and Synthetic Agrobiotech Center (SSAC), Plant Molecular Biology and Biotechnology Research Center (PMBBRC), Research Institute of Natural Science (RINS), Gyeongsang National University (GNU), 501 Jinju-daero, Jinju, 660-701 Republic of Korea.
Aim: Recent evidence suggests that aldo-keto reductase family 1 B10 (AKR1B10) may be a potential diagnostic or prognostic marker of human tumors, and that AKR1B10 inhibitors offer a promising choice for treatment of many types of human cancers. The aim of this study was to identify novel chemical scaffolds of AKR1B10 inhibitors using in silico approaches.
Methods: The 3D QSAR pharmacophore models were generated using HypoGen.
Structural Identification of a Non-Glycosylated Variant at Ser126 for O-Glycosylation Site from EPO BRP, Human Recombinant Erythropoietin by LC/MS Analysis.
Mol Cells
June 2015
Deptatment of Stereoscopic Media, Korean German Institute of Technology, Seoul 157-930, Korea.
Article Synopsis
- A variant peak of recombinant human erythropoietin (rHu-EPO) was identified during RP-HPLC analysis, constituting about 7% of the total content.
- Mass analysis via ESI-TOF MS revealed that the variant peak has a molecular mass that is 600-1000 Da smaller than the main peak, indicating structural differences.
- Peptide mapping showed that the variant lacks O-glycopeptides at Ser126, leading to the conclusion that it is non-O-glycosylated rHu-EPO, while the main peak is fully O-glycosylated.
Personal computer wallpaper user segmentation based on typology.
Integr Med Res
March 2015
Newmedia Department, Korean German Institute of Technology, Seoul, Korea.
Background: As human-computer interaction (HCI) is becoming a significant part of all human life, the user's emotional satisfaction is an important factor to consider. These changes have been pointed out by several researchers who claim that a user's personality may become the most important factor in the design. The objective of this study is to examine typology as a user segmentation method in the area of HCI design.
View Article and Find Full Text PDFA target model construction algorithm for robust real-time mean-shift tracking.
Sensors (Basel)
November 2014
Department of Newmedia, Korean German Institute of Technology, 99, Hwagok-ro 61-gil, Gangseo-gu, Seoul 157-930, Korea.
Article Synopsis
- Mean-shift tracking is gaining popularity due to its ability to implement real-time and reliable tracking.
- The paper introduces a new method for generating an indicator function that minimizes background clutter by using prior knowledge about the target model.
- Results show that this improved target model enhances the robustness and accuracy of mean-shift object tracking.
Structural identification of modified amino acids on the interface between EPO and its receptor from EPO BRP, human recombinant erythropoietin by LC/MS analysis.
Mol Cells
November 2014
Department of Newmedia, Korean German Institute of Technology, Korea Research Institute of Standards and Science, Korea.
Article Synopsis
- - Protein modifications in recombinant pharmaceuticals can lead to decreased efficacy, changes in bioavailability, and increased antigenicity, making it crucial to monitor these modifications for quality assurance.
- - The study focused on erythropoietin (EPO) and its receptor, identifying specific amino acids involved in their interaction and noting two types of modifications in the recombinant human EPO (rHu-EPO BRP) preparation.
- - A UPLC/Q-TOF MS method was employed to analyze the extent of modifications, revealing that oxidation occurred at Met54 (3.0%) and deamidation at Asn47 (2.9%) and Asn147 (4.8%).