Ultrasensitive Flexible NO Sensors with Remote-Controllable ADC-Electropolymerized Conducting Polymers on Plastic.

Alternating- and direct-current (ADC) bipolar electropolymerization (EP) offers an efficient and scalable approach for the lateral synthesis of conjugated macromolecules, enabling the simultaneous polymerization and deposition of large conducting polymer films with intriguing fractal-like ramified topographies onto arbitrary insulating substrates under remote control. In this study, we presented the remote synthesis of poly(3,4-ethylenedioxythiophene) (PEDOT):anion sensing films on a plastic substrate, aimed at their use in flexible nitrogen dioxide (NO) gas sensors. Notably, the PEDOT:ClO films exhibited excellent gas-sensing characteristics, with a sensitivity of 54.

Comparative efficacy and safety of stent retrievers as a bailout strategy following failed contact aspiration technique in acute stroke thrombectomy.

Background: The contact aspiration (CA) technique is often used to perform endovascular thrombectomy (EVT) for acute ischemic stroke (AIS); however, rescue strategies are necessary if CA fails to achieve recanalization. This study investigates the outcomes of incorporating stent retriever (SR) thrombectomy in the rescue strategy following failed CA.

Methods: EVT patients with failed CA attempts were identified from a large multicenter registry and stratified by rescue technique: CA alone or incorporating SR in the rescue strategy.

Cryo-EM structures reveal the H/citrate symport mechanism of INDY.

I'm Not Dead Yet (INDY) functions as a transporter for citrate, a key metabolite in the citric acid cycle, across the plasma membrane. Partial deficiency of INDY extends lifespan, akin to the effects of caloric restriction. In this work, we use cryo-electron microscopy to determine structures of INDY in the presence and absence of citrate and in complex with the well-known inhibitor 4,4'-diisothiocyano-2,2'-disulfonic acid stilbene (DIDS) at resolutions ranging from 2.

The Small Cycloamylose (CA15) Synthesizing Properties of 4-α-Glucanotransferase from Hyperthermophilic Archaeon with Its Distinct Disproportionation Activity.

4-α-Glucanotransferase (4-α-GTase, EC 2.4.1.

Anatomical considerations for thread-based brow lifting and wrinkle treatment.

This review explores the anatomical considerations and technical aspects of thread lifting for the forehead and eyebrow, focusing on the relationships between vascular structures, muscular anatomy, and age-related changes in the forehead-eyebrow complex. It highlights the critical importance of understanding neurovascular pathways, particularly the supratrochlear and supraorbital vessels, as well as the appropriate thread placement techniques necessary for optimal outcomes. The review demonstrates that I-shaped threads, when placed beneath the frontalis muscle, provide a safer and equally effective alternative to traditional U-shaped designs.

Physicians Who Provide Primary Care in US Nursing Homes: Characteristics and Care Patterns.

Objectives: To examine practice trends and characteristics of primary care physicians providing care in US nursing homes.

Design: Retrospective cohort study using Medicare Fee-for-Service claims.

Setting And Participants: Physicians who provided primary care to long-stay nursing home residents.

In vitro and in vivo efficacy studies of an engineered endolysin targeting gram-negative pathogens.

Endolysins have drawn considerable attention as viable modalities for antibiotic use. The most significant obstacle for Gram-negative targeting endolysins is the presence of the outer membrane barrier. A heterologously expressed endolysin encoded by bacteriophage PBPA90 infecting Pseudomonas aeruginosa exhibited intrinsic antibacterial activity against P.

State-of-the-art progress and prospect of metal-organic frameworks and composites for photoelectrochemical amino-drugs sensing.

Unregulated discharge of antibiotics in waterbodies has posed significant threat to the aquatic flora and fauna in post-pandemic times. This alarming situation has ascertained the need for suitable sensors to detect persistent antibiotic residues. In this context, functional hybrid materials centralized on reticular metal-organic frameworks (MOFs)/composites have been a research hot spot for photoelectrochemical host-guest recognition events over the past two decades.

Diagnostic Performance of the Modified Lung-RADS in a Tuberculosis-endemic Country: The Korean National Lung Cancer Screening Program.

Background: In 2019, Korea initiated the world's first national low-dose computed tomography (CT) lung cancer screening (LCS) program, adapting the Lung CT Screening Reporting and Data System (Lung-RADS) to counteract the high false-positive rates driven by prevalent tuberculosis.

Research Question: Does the modified Lung-RADS enhance screening specificity while maintaining sensitivity?

Study Design And Methods: This nationwide, retrospective, cohort study included high-risk current smokers aged 54 to 74 with at least 30 pack-years, participating in the national LCS program from 2019 to 2020. The modified Lung-RADS 1.

Smart theranostic contact lenses.

Although smart contact lenses have demonstrated great potential in theranostics, there remain critical challenges and opportunities in their commercial development. In this Perspective, the current status and capability of smart theranostic contact lenses are highlighted, focusing on their application as sensing systems for detecting biomarkers such as glucose, intraocular pressure (IOP), and inflammatory cytokines, and as drug delivery systems (DDS) for precise and controlled therapy. Additionally, key challenges associated with clinical development and commercialization of smart theranostic contact lenses are discussed, to optimize diagnostic and therapeutic interventions.

In-vivo high-resolution χ-separation at 7T.

A recently introduced quantitative susceptibility mapping (QSM) technique, χ-separation, offers the capability to separate paramagnetic (χ) and diamagnetic (χ) susceptibility distribution within the brain. In-vivo high-resolution mapping of iron and myelin distribution, estimated by χ-separation, could provide a deeper understanding of brain substructures, assisting the investigation of their functions and alterations. This can be achieved using 7T MRI, which benefits from a high signal-to-noise ratio and susceptibility effects.

Cypermethrin triggers oxidative stress, apoptosis, and inflammation in bovine mammary glands by disruption of mitogen-activated protein kinase (MAPK) pathways and calcium homeostasis.

Cyano-(3-phenoxyphenyl)methyl]3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate (cypermethrin) is a pyrethroid insecticide that is widely used to repel insects, such as cockroaches and ants. In addition to the target insects, its hazards have been outlined for carp; mice; and the nervous, reproductive, and gastrointestinal systems of humans. However, the effects of cypermethrin on the mammary tissue and milk production in dairy cattle remain unknown.

Investigation of potential toxic effects of nano- and microplastics on human endometrial stromal cells.

Nanoplastics (NPs) and microplastics (MPs) have become a global concern in recent years. Most current research on the impact of plastics on obstetrics has focused on their accumulation in specific tissues in animal models and the disease-causing potential of MPs. However, there is a relative lack of research on the cellular changes caused by the accumulation of MPs.

Association between menopausal age and smoking status defined using urinary cotinine or tobacco-specific nitrosamine metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol: The Korea National Health and Nutrition Examination Survey 2016-2018.

This study aimed to establish the optimal cut-off values for urinary cotinine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL)to determine smoking status in Korean women over 20 years of age and to assess the correlation of these biomarkers with reproductive health, particularly menopausal age, in postmenopausal women. Utilizing data from the 7th edition of the Korea National Health and Nutrition Examination Survey (2016- 2018), researchers included postmenopausal women aged 40-60 years who were within 5 years of menopause. Self-reported smoking status was aligned with biomarkers levels to calculate optimal cut-off values, classifying a total of 503 postmenopausal women into four groups: never smokers (cotinine <0.

Age-related eye diseases and subsequent risk of mental disorders in older adults: A real-world multicenter study.

Background: The relationship between age-related eye diseases and the subsequent risk of dementia and depressive disorders remains inconsistent. Furthermore, the effects on anxiety disorders and sleep disorders have been underexplored. This study aims to comprehensively examine the impact of age-related eye diseases on common mental disorders in older adults, thereby enhancing our understanding of the mental health implications in these conditions.

Identification of a novel fibroblast growth factor receptor-agonistic peptide and its effect on diabetic wound healing.

Aims: Fibroblast growth factor (FGF) is a broad class of secretory chemicals that act via FGF receptors (FGFR). The study aims to explore the role of a novel peptide, FAP1 (FGFR-agonistic peptide 1), in tissue regeneration and repair. It investigates whether FAP1 mimics basic fibroblast growth factor (bFGF) and accelerates wound healing both in vitro and in vivo.

Vaccines and AMR: An analysis of the funding landscape for human bacterial vaccines in low-and middle-income countries.

Background: Vaccines are critical tools to prevent the emergence and spread of antimicrobial resistance (AMR) through prevention of infection and reduction of subsequent antibiotic use. Since AMR is a critical issue disproportionately affecting Low- and Middle- Income Countries (LMICs), we examined investments in research and development for bacterial vaccines with a focus on LMIC-driven research.

Methods: Publicly available funding data on projects active from January 2007 to 15 January 2024 from the G-FINDER and Global AMR R&D Hub databases were analysed.

Sustainable removal of gaseous Hg using sulfur functionalized biochar: Adsorption experiment and life cycle assessment.

Maximizing the sorption capacity of gaseous Hg by sulfur-functionalized biochar can lead to increased energy consumption and the production of secondary environmental pollutants such as greenhouse gases. This study evaluates the environmental impact of producing sulfurized biochar through a life cycle assessment (LCA), weighing these impacts against the benefits of enhanced Hg removal efficiencies. The biochar's Hg adsorption capacity, which ranges between 3 and 22 μg-Hg/g-biochar, is influenced by several factors: it increases with higher sulfur loading (0-15 %), higher O levels (0-21 %), and longer pyrolysis times (1-5 h).

The relationship between trajectories of intrinsic capacity and differences in the risk of functional ability decline in community-dwelling older adults: A socio-ecological approach.

Background: Functional ability (FA), a key determinant of healthy aging, is determined by intrinsic capacity (IC), environmental factors, and their interactions. IC is a composite of physical and mental capacities that undergo constant change. Therefore, understanding the factors that influence IC requires a multi-level analysis of individuals to optimize its trajectory.

ExPDrug: Integration of an interpretable neural network and knowledge graph for pathway-based drug repurposing.

Precision medicine aims to provide personalized therapies by analyzing patient molecular profiles, often focusing on gene expression data. However, effectively linking these data to actionable drug discovery for clinical application remains challenging. In this paper, we introduce ExPDrug, a neural network (NN) model that integrates biological pathways from transcriptomic data with a biomedical knowledge graph to facilitate pathway-based drug repurposing.

Plumbagin ameliorates renal fibrosis by suppressing epithelial-mesenchymal transition.

Renal fibrosis is a common pathological feature of chronic kidney diseases (CKDs), driven by excessive extracellular matrix (ECM) accumulation. Despite its prevalence, therapeutic candidates specifically targeting fibrosis are limited, and the role of renal tubular epithelial cells in fibrosis pathogenesis remains unclear. In this study, we evaluated the anti-fibrotic effects of Plumbagin, a plant-derived natural compound, using a folic acid-induced renal fibrosis model that simulates proximal tubular injury-driven fibrosis.

Revealing structure-performance relationship of biomimetic cyclodextrin metal-organic framework composite electrolytes for dendrite-free lithium metal batteries.

Cyclodextrin metal-organic frameworks (CD-MOFs) with infinitely extensible network structures show potential applications in lithium metal batteries. However, the disordered accumulation of CD-MOF particles leads to slow interparticle diffusion of ions, so the CD-MOF composite electrolytes are needed to be developed. In addition, the influences of CD-MOFs structure on the electrochemical performance of the composite electrolytes remains unclear.

Hybrid combination of advanced oxidation process with membrane technology for wastewater treatment: gains and problems.

Over the past few decades, significant efforts have been dedicated to advancing technologies for the removal of micropollutants from water. Achieving complete pure water with a single treatment process is challenging and nearly impossible. One promising approach among various alternatives is adopting hybrid technology, which is considered as a win-win technology.