2 results match your criteria: "Korea Research Institute of Chemical Technologygrid.29869.3c[Affiliation]"
Immunological and Pathological Peculiarity of Severe Acute Respiratory Syndrome Coronavirus 2 Beta Variant.
Microbiol Spectr
October 2022
Center for Convergent Research of Emerging Virus Infection, Korea Research Institute of Chemical Technologygrid.29869.3c, Daejeon, South Korea.
Article Synopsis
- A study investigated the beta variant of SARS-CoV-2, finding it leads to slower disease progression early on but can cause sudden death later in infected mice.
- The beta variant enhances the activation of certain immune signaling pathways, leading to increased neutrophil recruitment and lung damage compared to the ancestral strain.
- Blockading the cytokine CCL2 during early infection reduced weight loss and delayed mortality, highlighting the potential for targeted treatments against this variant.
SARS-CoV-2 Infection of Microglia Elicits Proinflammatory Activation and Apoptotic Cell Death.
Microbiol Spectr
June 2022
Center for Convergent Research for Emerging Virus Infection, Korea Research Institute of Chemical Technologygrid.29869.3c, Daejeon, Republic of Korea.
Article Synopsis
- SARS-CoV-2 infection leads to various neurological symptoms in COVID-19 patients, significantly affecting microglial immune responses in the brain.
- The virus can directly infect human microglia, causing them to become proinflammatory (M1-like) and subsequently resulting in cell death through inflammatory responses and apoptotic processes.
- Findings in transgenic mice show that SARS-CoV-2 infection triggers chronic microglial damage and highlights the potential for targeting microglia in therapies for neurological issues related to COVID-19.