2-Methoxyestradiol Inhibits Radiation-Induced Skin Injuries.

Radiation-induced skin injury (RISI) is a main side effect of radiotherapy for cancer patients, with vascular damage being a common pathogenesis of acute and chronic RISI. Despite the severity of RISI, there are few treatments for it that are in clinical use. 2-Methoxyestradiol (2-ME) has been reported to regulate the radiation-induced vascular endothelial-to-mesenchymal transition.

Radiation-Induced Fibrotic Tumor Microenvironment Regulates Anti-Tumor Immune Response.

High linear energy transfer (LET) radiation, such as neutron radiation, is considered more effective for the treatment of cancer than low LET radiation, such as X-rays. We previously reported that X-ray irradiation induced endothelial-to-mesenchymal transition (EndMT) and profibrotic changes, which contributed to the radioresistance of tumors. However, this effect was attenuated in tumors of endothelial-specific Trp53-knockout mice.

Pharmacologic Inhibition of HIF-1α Attenuates Radiation-Induced Pulmonary Fibrosis in a Preclinical Image Guided Radiation Therapy.

Purpose: Radiation-induced pulmonary fibrosis (RIPF) is a long-term side effect of thoracic radiation therapy. Hypoxia-induced vascular endothelial mesenchymal transition (EndMT) can occur during the development of RIPF. Here, we examined the direct contribution of endothelial HIF-1α (EC-HIF1α) on RIPF.

Performance evaluation of a Compton SPECT imager for determining the position and distribution of Ac in targeted alpha therapy: A Monte Carlo simulation based phantom study.

In this study, the performance of a Compton Single Photon Emission Computed Tomography (SPECT) imager when in vivo monitoring the position and distribution of Ac radionuclide in targeted alpha therapy (TAT) was evaluated. When Ac radionuclide, which emits various γ-rays (218 and 440 keV), is used in TAT, both the photoelectric and Compton scattering events can be used for image reconstruction. Moreover, all information pertaining to the various γ-rays of the Ac radionuclide can be individually or simultaneously utilized in the reconstructed image.

Performance of a virtual frisch-grid CdZnTe detector for prompt γ-ray induced by 14 MeV neutrons: Monte Carlo simulation study.

The performance of a virtual (6 × 6 × 15 mm) Frisch-grid cadmium zinc telluride detector for the detection of contraband with 14 MeV neutron-activation prompt γ-rays was studied using Monte Carlo simulations. A sensitive nonlinear iterative peak clipping algorithm was applied to the spectra to rapidly and easily identify the prompt γ-ray peaks. This algorithm showed better performance than directly using the original spectra.