96 results match your criteria: "Korea Advanced Institute of Science Technology (KAIST)[Affiliation]"
Adv Mater
January 2025
Department of Bio and Brain Engineering, Korea Advanced Institute of Science Technology (KAIST), Daejeon, 34141, Republic of Korea.
Cancer immunotherapy, specifically Chimeric Antigen Receptor (CAR)-T cell therapy, represents a significant breakthrough in treating cancers. Despite its success in hematological cancers, CAR-T exhibits limited efficacy in solid tumors, which account for more than 90% of all cancers. Solid tumors commonly present unique challenges, including antigen heterogeneity and complex tumor microenvironment (TME).
View Article and Find Full Text PDFChem Sci
December 2024
Department of Chemistry, Korea Advanced Institute of Science & Technology (KAIST) Daejeon 34141 Republic of Korea
Securinega alkaloids, known for their unique structures and neuroplasticity-inducing potential, are promising candidates for treating neurodegenerative diseases such as depression and substance use disorders (SUD). Herein, we delineate the total synthesis of two dimeric Rauhut-Currier (RC) reaction-based securinega alkaloids, (-)-flueggenine A and (-)-15'--flueggenine D. The key step involved a novel reductive Heck dimerization strategy, utilizing a silyl-tethered enone coupling partner to ensure the desired reactivity and stereoselectivity.
View Article and Find Full Text PDFNano Lett
December 2024
School of Electrical Engineering, Korea Advanced Institute of Science & Technology (KAIST), Daejeon 34141, Republic of Korea.
van der Waals (vdW) indium selenide (InSe) is receiving attention for its exceptional electron mobility and moderate band gap, enabling various applications. However, the intrinsic -type behavior of InSe has restricted its use predominantly to -type devices, constraining its application in complementary integrated microsystems. Here, we show superior ambipolar InSe transistors with vdW bottom contacts, achieving impressive -type on/off current ratios greater than 10 and Schottky barrier heights approaching the ideal Schottky-Mott limit.
View Article and Find Full Text PDFACS Appl Mater Interfaces
October 2024
Department of Mechanical Engineering, Korea Advanced Institute of Science & Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Republic of Korea.
Multifunctional structural batteries promise advancements in structural energy storage technologies by seamlessly integrating load-bearing and energy-storage functions within a single material, reducing weight, and enhancing safety. Yet, commercialization faces challenges in materials processing, assembly, and design optimization. Here, we report a systematic approach to develop a carbon fiber (CF)-based structural battery impregnated with epoxy-based solid polymer electrolyte (SPE) via robust vacuum-assisted compression molding (VACM).
View Article and Find Full Text PDFOrg Lett
August 2024
Department of Chemistry, Korea Advanced Institute of Science & Technology (KAIST), Daejeon 34141, Republic of Korea.
Chemical synthesis plays a crucial role in confirming and revising the structures of natural products. Through meticulous synthetic efforts, NMR spectroscopic and single-crystal X-ray diffraction analyses, DFT calculations, and mass spectrometric investigations, we revised the structure of securingine E. The revised structure of securingine E was unambiguously confirmed by its chemical synthesis.
View Article and Find Full Text PDFiScience
August 2024
Department of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon 16419, Republic of Korea.
The isolation of a natural product conventionally precedes its chemical synthesis. Often, the isolation and structure determination of a natural product present in minute quantities in its natural source pose formidable challenges, akin to finding "a needle in a haystack." On the other hand, leveraging plausible biosynthetic insights and biomimetic synthetic expertise would allow for the prior synthesis of presumed natural products, followed by their verification in natural sources.
View Article and Find Full Text PDFSensors (Basel)
August 2024
School of Electrical Engineering, Korea Advanced Institute of Science & Technology (KAIST), Daejeon 34141, Republic of Korea.
Federated Learning (FL) is a decentralized machine learning method in which individual devices compute local models based on their data. In FL, devices periodically share newly trained updates with the central server, rather than submitting their raw data. The key characteristics of FL, including on-device training and aggregation, make it interesting for many communication domains.
View Article and Find Full Text PDFSmall
November 2024
Nanotechnology Research Institute, Jiaxing University, Jiaxing, 314001, P. R. China.
Silicon (Si) is a promising anode material for lithium-ion batteries, but its large volume expansion during cycling poses a challenge for the binder design. In this study, a novel gelatin binder is designed and prepared with a helical crosslinked network structure. This gelatin binder is prepared by enzymatic crosslinking and immersion in Hofmeister salt solution, which induces the formation of network and helical secondary structures.
View Article and Find Full Text PDFOrg Lett
July 2024
Department of Chemistry, Korea Advanced Institute of Science & Technology (KAIST), Daejeon 34141, Republic of Korea.
The generation of radical intermediates via SET-mediated deoxygenation of activated alcohol derivatives is desirable, as alcohols can be utilized in various radical-mediated reactions. Herein, we introduce α--phthalimido-oxy isobutyrate (NPIB) as a novel activating group for alcohols. Essentially, it is a more chemically robust alternative to Overman's -phthalimidoyl oxalate group.
View Article and Find Full Text PDFAPL Bioeng
June 2024
Department of Mechanical Engineering, Korea Advanced Institute of Science & Technology (KAIST), Daejeon, Korea.
The understanding of cancer has evolved significantly, with the tumor microenvironment (TME) now recognized as a critical factor influencing the onset and progression of the disease. This broader perspective challenges the traditional view that cancer is primarily caused by mutations, instead emphasizing the dynamic interaction between different cell types and physicochemical factors within the TME. Among these factors, cancer-associated fibroblasts (CAFs) command attention for their profound influence on tumor behavior and patient prognoses.
View Article and Find Full Text PDFChem Commun (Camb)
June 2024
Department of Chemistry, Korea Advanced Institute of Science & Technology (KAIST), Daejeon 34141, Republic of Korea.
In this study, we present the first total synthesis of (-)-securingine G. Diverging from the proposed biosynthetic pathway, our approach involves the addition of nucleophilic pyridine anion species to the electrophilic menisdaurilide congener. Crucially, incorporating a weakly basic yet nucleophilic tri(2-pyridinyl)lanthanum complex proved essential to circumvent undesired base-mediated pathways during the key coupling reaction.
View Article and Find Full Text PDFCells
May 2024
Department of Molecular Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea.
ACS Appl Mater Interfaces
March 2024
Oxide and Organic Nanomaterials for Energy and Environment (ONE) Lab, Chemistry Program, Advanced Membranes & Porous Materials Center, KAUST Catalysis Center, Physical Science & Engineering (PSE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955, Saudi Arabia.
Fluoride is widely present in nature, and human exposure to it is generally regarded as inevitable. High levels of fluoride intake induce acute and chronic illnesses. To reduce potential harm to the general public, it is essential to create selective fluoride detectors capable of providing a colorimetric response for naked-eye detection without the need for sophisticated equipment.
View Article and Find Full Text PDFPolymers (Basel)
March 2024
Department of Chemistry, Korea Advanced Institute of Science & Technology (KAIST), Daejeon 34141, Republic of Korea.
Thermo-responsive diblock copolymer, poly(-isopropylacrylamide)--poly(-vinylisobutyramide) was synthesized via switchable reversible addition-fragmentation chain transfer (RAFT) polymerization and its thermal transition behavior was studied. Poly(-vinylisobutyramide) (PNVIBA), a structural isomer of poly(-isopropylacrylamide) (PNIPAM) shows a thermo-response character but with a higher lower critical solution temperature (LCST) than PNIPAM. The chain extension of the PNVIBA block from the PNIPAM block proceeded in a controlled manner with a switchable chain transfer reagent, methyl 2-[methyl(4-pyridinyl)carbamothioylthio]propionate.
View Article and Find Full Text PDFBioresour Technol
May 2024
Cell Factory Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea; Department of Environmental Biotechnology, KRIBB School of Biotechnology, University of Science & Technology (UST), Daejeon 34113, Republic of Korea. Electronic address:
A halotolerant consortium between microalgae and methanotrophic bacteria could effectively remediate in situ CH and CO, particularly using saline wastewater sources. Herein, Methylomicrobium alcaliphilum 20Z was demonstrated to form a mutualistic association with Chlorella sp. HS2 at a salinity level above 3.
View Article and Find Full Text PDFFront Chem
January 2024
Department of Chemistry, Korea Advanced Institute of Science & Technology (KAIST), Daejeon, Republic of Korea.
Securinega alkaloids have intrigued chemists since the isolation of securinine in 1956. This family of natural products comprises a securinane subfamily with a piperidine substructure and norsecurinane alkaloids featuring a pyrrolidine core. From a biosynthetic perspective, the piperidine moiety in securinane alkaloids derives from lysine, whereas the pyrrolidine moiety in norsecurinane natural products originates from ornithine, marking an early biogenetic divergence.
View Article and Find Full Text PDFBioresour Technol
February 2024
Synthetic Biology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea; Department of Biosystems and Bioengineering, KRIBB School of Biotechnology, University of Science & Technology (UST), Daejeon 34113, Republic of Korea; Graduate School of Engineering Biology, Korea Advanced Institute of Science & Technology (KAIST), Daejeon 34141, Republic of Korea. Electronic address:
Isoprene has numerous industrial applications, including rubber polymer and potential biofuel. Microbial methane-based isoprene production could be a cost-effective and environmentally benign process, owing to a reduced carbon footprint and economical utilization of methane. In this study, Methylococcus capsulatus Bath was engineered to produce isoprene from methane by introducing the exogenous mevalonate (MVA) pathway.
View Article and Find Full Text PDFMed Image Anal
January 2024
Kim Jaechul Graduate School of AI, Korea Advanced Institute of Science & Technology (KAIST), Daejeon, Republic of Korea. Electronic address:
Blood vessel segmentation in medical imaging is one of the essential steps for vascular disease diagnosis and interventional planning in a broad spectrum of clinical scenarios in image-based medicine and interventional medicine. Unfortunately, manual annotation of the vessel masks is challenging and resource-intensive due to subtle branches and complex structures. To overcome this issue, this paper presents a self-supervised vessel segmentation method, dubbed the contrastive diffusion adversarial representation learning (C-DARL) model.
View Article and Find Full Text PDFJ Am Chem Soc
November 2023
Department of Chemistry, Korea Advanced Institute of Science & Technology (KAIST), Daejeon 34141, Republic of Korea.
Efficiently generating intricate molecular complexity is a coveted goal in organic synthesis. This can be realized through the implementation of inventive and audacious strategies coupled with the exploration and advancement of novel molecular reactivity pathways. Herein, we present a concise two-step synthesis of a high-oxidation state heterotrimeric securinega alkaloid, suffranidine B, from 2,3-dehydroallosecurinine and the vinylogous ketoaldehyde compound derived from kojic acid.
View Article and Find Full Text PDFPolymers (Basel)
October 2023
MLCC Green Chip Lab, MLCC Development Team, Samsung Electro-Mechanics, Suwon-si 16674, Republic of Korea.
To fabricate multilayer ceramic capacitors (MLCCs) that can withstand external impacts, technologies to achieve excellent adhesion and mechanical strength of the cover layer should be essentially developed. Low adhesion and strength of the cover layer can lead to delamination and cracks in the MLCC, respectively. In this study, we present a method for applying polydopamine (PDA), a mussel-inspired adhesive protein, for as robust cover layer on an MLCC.
View Article and Find Full Text PDFNeuron
November 2023
Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA; McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:
Sensors (Basel)
March 2023
Hebei Higher Institute of Transportation Infrastructure Research, Development Center for Digital and Intelligent Technology Application, Cangzhou 061001, China.
This paper focuses on the safety issue for cyclists and pedestrians at unsignalized intersections. The cycling speed needs to be calmed when approaching the intersection. This study proposes and deploys an integrated portable ultra-wideband/inertial navigation system (UWB/INS) to extract cycling trajectories for a cycling safety study.
View Article and Find Full Text PDFSmall
May 2023
Massachusetts Institute of Technology, Department of Materials Science & Engineering, 77 Massachusetts Ave, Cambridge, MA, 02139, USA.
Iono-electronics, that is, transducing devices able to translate ionic injection into electrical output, continue to demand a variety of mixed ionic-electronic conductors (MIECs). Though polar sidechains are widely used in designing novel polymer MIECs, it remains unclear to chemists how much balance is needed between the two antagonistic modes of transport (ion permeability and electronic charge transport) to yield high-performance materials. Here, the impact of molecularly hybridizing ion permeability and charge mobility in semiconducting polymers on their performance in electrochemical and synaptic transistors is investigated.
View Article and Find Full Text PDFAcc Chem Res
January 2023
Department of Chemistry, Korea Advanced Institute of Science & Technology (KAIST), Daejeon 34141, Republic of Korea.
alkaloids, composed of more than 100 members characterized by the compact tetracyclic scaffold, have fascinated the synthetic community with their structural diversity and notable bioactivities. On the basis of the structural phenotype, oligomerizations and oxidations are major biosynthetic diversification modes of the basic framework. Despite the rich history of synthesis of basic monomeric alkaloids, the synthesis of oligomeric alkaloids, as well as oxidized derivatives, has remained relatively unexplored because of their extra structural complexity.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2023
School of Electrical Engineering, Korea Advanced Institute of Science & Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon34141, Korea.
Ferroelectric field-effect transistors (FeFETs) have attracted enormous attention for low-power and high-density nonvolatile memory devices in processing-in-memory (PIM). However, their small memory window (MW) and limited endurance severely degrade the area efficiency and reliability of PIM devices. Herein, we overcome such challenges using key approaches covering from the material to the device and array architecture.
View Article and Find Full Text PDF