Production of the antimalarial drug precursor amorphadiene by microbial terpene synthase-like from the moss Sanionia uncinata.

The microbial terpene synthase-like of the moss Sanionia uncinata displays the convergent evolution of a rare plant metabolite amorpha-4,11-diene synthesis. Despite increasing demand for the exploration of biological resources, the diversity of natural compounds synthesized by organisms inhabiting various climates remains largely unexplored. This study focuses on the moss Sanionia uncinata, known as a predominant species within the polar climates of the Antarctic Peninsula, to systematically explore its metabolic profile both in-field and in controlled environments.

Author Correction: SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function.

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The prognostic impact of psychiatric intervention on alcohol-associated liver disease: The UK Biobank cohort study.

Background/aims: Alcohol-associated liver disease (ALD) is a public health concern. ALD patients often have psychiatric comorbidities, but the effects of psychiatric interventions on ALD are not well-established. This study explores the prognostic impact of psychiatric intervention on ALD within UK Biobank cohort.

Heartbeat-related spectral perturbation of electroencephalogram reflects dynamic interoceptive attention states in the trial-by-trial classification analysis.

Attending to heartbeats for interoceptive awareness initiates distinct electrophysiological responses synchronized with the R-peaks of an electrocardiogram (ECG), such as the heartbeat-evoked potential (HEP). Beyond HEP, this study proposes heartbeat-related spectral perturbation (HRSP), a time-frequency map of the R-peak locked electroencephalogram (EEG), and explores its characteristics in identifying interoceptive attention states using a classification approach. HRSPs of EEG brain components specified by independent component analysis (ICA) were used for the offline and online classification of interoceptive states.

Primary Metabolic Response of to Simulated Specialist Herbivory under Elevated CO Conditions.

This study explores how elevated carbon dioxide (CO) levels affects the growth and defense mechanisms of plants. We focused on Bunge (Aristolochiaceae), a wild plant that exhibits growth reduction under elevated CO in the previous study. The plant has Gray (Papilionidae) as a specialist herbivore.

Life under the snow: A year-round transcriptome analysis of Antarctic mosses in natural habitats provides insight into the molecular adaptation of plants under extreme environment.

Mosses are vital components of ecosystems, exhibiting remarkable adaptability across diverse habitats from deserts to polar ice caps. Sanionia uncinata (Hedw.) Loeske, a dominant Antarctic moss survives extreme environmental condition through perennial lifecycles involving growth and dormancy alternation.

Effect of flatfoot correction on the ankle joint following lateral column lengthening: A radiographic evaluation.

Objectives: The effects of foot deformities and corrections on the ankle joint without osteoarthritis has received little attention. This study aimed to investigate the effect of flatfoot correction on the ankle joint of patients without osteoarthritis.

Methods: Thirty-five patients (24 men and 11 women; mean age 17.

Where should siRNAs go: applicable organs for siRNA drugs.

RNA interference mediated by small interfering RNAs (siRNAs) has been exploited for the development of therapeutics. siRNAs can be a powerful therapeutic tool because the working mechanisms of siRNAs are straightforward. siRNAs determine targets based on their sequence and specifically regulate the gene expression of the target gene.

CRISPR/Cas9-mediated gene editing to confer turnip mosaic virus (TuMV) resistance in Chinese cabbage ().

Genome editing approaches, particularly the CRISPR/Cas9 technology, are becoming state-of-the-art for trait development in numerous breeding programs. Significant advances in improving plant traits are enabled by this influential tool, especially for disease resistance, compared to traditional breeding. One of the potyviruses, the turnip mosaic virus (TuMV), is the most widespread and damaging virus that infects spp.

Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice.

Autism spectrum disorders (ASD) represent neurodevelopmental disorders characterized by social deficits, repetitive behaviors, and various comorbidities, including epilepsy. ANK2, which encodes a neuronal scaffolding protein, is frequently mutated in ASD, but its in vivo functions and disease-related mechanisms are largely unknown. Here, we report that mice with Ank2 knockout restricted to cortical and hippocampal excitatory neurons (Ank2-cKO mice) show ASD-related behavioral abnormalities and juvenile seizure-related death.

Age-differential sexual dimorphisms in CHD8-S62X-mutant mouse synapses and transcriptomes.

mice with a human C-terminal-truncating mutation (N2373K) display autistic-like behaviors in juvenile and adult males but not in females. In contrast, mice with a human N-terminal-truncating mutation (S62X) display behavioral deficits in juvenile males (not females) and adult males and females, indicative of age-differential sexually dimorphic behaviors. Excitatory synaptic transmission is suppressed and enhanced in male and female juveniles, respectively, but similarly enhanced in adult male and female mutants.

Circular RNAs in and out of Cells: Therapeutic Usages of Circular RNAs.

RNAs are versatile molecules that are primarily involved in gene regulation and can thus be widely used to advance the fields of therapeutics and diagnostics. In particular, circular RNAs which are highly stable, have emerged as strong candidates for use on next-generation therapeutic platforms. Endogenous circular RNAs control gene regulatory networks by interacting with other biomolecules or through translation into polypeptides.

Heritable Virus-Induced Genome Editing (VIGE) in Nicotiana attenuata.

The CRISPR/Cas9 system is an extremely powerful tool for targeted mutagenesis in plants. However, plant genome editing relies on the labor-intensive plant regeneration method for generating gene-edited plants. To overcome this bottleneck, several virus-induced genome editing (VIGE) techniques have been developed.

Spectral noise and data reduction using a long short-term memory network for nonlinear ultrasonic modulation-based fatigue crack detection.

This paper presents a spectral noise and data reduction technique based on long short-term memory (LSTM) network for nonlinear ultrasonic modulation-based fatigue crack detection. The amplitudes of the nonlinear modulation components created by a micro fatigue crack are often very small and masked by noise. In addition, the collection of large amounts of data is often undesirable owing to the limited power, data storage, and data transmission bandwidth of monitoring systems.

Flavone-associated resistance of two species to duckweed weevil attack.

and are free-floating plants that often live in the same habitat. However, little is known about how they differ in response to herbivore attacks. In this study, we examined the species-specific resistance of two species to the duckweed weevil, .

Age-differential sexual dimorphism in CHD8-S62X-mutant mouse behaviors.

Autism spectrum disorders (ASD) are ~4-times more common in males than females, and CHD8 (a chromatin remodeler)-related ASD shows a strong male bias (~4:1), although the underlying mechanism remains unclear. -mutant mice with a C-terminal protein-truncating mutation (N2373K) display male-preponderant behavioral deficits as juveniles and adults, although whether this also applies to other mutations remains unknown. In addition, it remains unclear whether sexually dimorphic phenotypes in -mutant mice are differentially observed in males and females across different ages.

Jasmonate regulates plant resistance to by inducing indole glucosinolate biosynthesis.

() is a necrotrophic bacterium that causes the soft rot disease in . However, the mechanisms underlying plant immune responses against necrotrophic bacterial pathogens with a broad host range are still not well understood. Using a flg22-triggered seedling growth inhibition (SGI) assay with 455 inbred lines, we selected six flagellin-insensitive lines (fin2-7) and three flagellin-sensitive lines (fs1-3).