Analysis of morphology, cytotoxicity, and water content characteristics of freeze-dried amnion membrane from human and bovine.

Placenta tissue has biological advantages, including anti-inflammatory, anti-bacterial, anti-fibrotic formation, and immunomodulatory properties. The amnion membrane (AM) is an inner side membrane of the placenta that faces the fetus. The main sources of amnion are humans and animals, with bovine being one of the significant sources.

Colorectal metastasis from gastric cancer: insights from a 14-year case series at a tertiary hospital.

Background: Colorectal metastasis from gastric cancer is very rare, with existing literature limited to only a few case reports. This study was designed to investigate the clinicopathological features and prognosis of colorectal metastasis arising from gastric cancer.

Methods: Patients with colorectal metastasis from gastric cancer who underwent surgical intervention at a single tertiary hospital between January 2010 and June 2023 were included, and their clinicopathological characteristics and oncologic outcomes were analyzed.

Parents' perceptions of risk and protective factors for problematic sexual behaviour in young Korean individuals with developmental disabilities.

Background: Limited data exist on problematic sexual behaviour (PSB) in youth with developmental disabilities in South Korea.

Method: Sixty-one parents of children with intellectual disabilities or autism spectrum disorder (aged 13-30) reported children's PSB and emotional, behavioural, cognitive, and interpersonal factors. The frequency of PSB in children with developmental disabilities was verified, and various factors' effects on PSB were examined through multiple linear regression analysis.

Computational Insights into "Lone Pair-Lone Pair Interaction-Controlled" Isomerization in the Asymmetric Total Syntheses of (+)-3-()-Laureatin and (+)-3-()-Isolaureatin.

Described herein is our computational study to rationalize the stereoselective epimerization of α,α'--disubstituted oxolane and oxetane ketones and to the corresponding α,α'- ketones and reported in our previous total syntheses of (+)-3-()-isolaureatin () and (+)-3-()-laureatin (). Density functional theory (DFT) calculations using appropriately truncated models revealed that the α,α'- ketones are more stable than the α,α'- ketones, in very good agreement with experimental results. The computational results showed that the isomer with a longer interatomic distance between the two ring oxygen atoms was lower in energy, which suggested the presence of repulsive interactions between those oxygen atoms.

Predicting Chlorophyll- Concentrations in the World's Largest Lakes Using Kolmogorov-Arnold Networks.

Accurate prediction of chlorophyll- (Chl-) concentrations, a key indicator of eutrophication, is essential for the sustainable management of lake ecosystems. This study evaluated the performance of Kolmogorov-Arnold Networks (KANs) along with three neural network models (MLP-NN, LSTM, and GRU) and three traditional machine learning tools (RF, SVR, and GPR) for predicting time-series Chl- concentrations in large lakes. Monthly remote-sensed Chl- data derived from Aqua-MODIS spanning September 2002 to April 2024 were used.

The impact of body mass index on mortality according to age in hemodialysis patients: an analysis of the Korean Renal Data System.

The impact of age on the relationship between body mass index (BMI) and all-cause mortality in hemodialysis (HD) patients is not clearly understood. We analyzed the association between BMI and all-cause mortality, stratified by age, in patients undergoing HD using data from the Korean Renal Data System (KORDS). We analyzed 66,129 HD patients from the 2023 KORDS database, with data collected between 2001 and 2022.

Safety of direct oral anticoagulants in hemodialysis patients with venous thromboembolism: an analysis using the Korean National Health Insurance Service database.

Background: Limited data exist regarding the safety of direct oral anticoagulants in hemodialysis patients with venous thromboembolic disease. This study aims to investigate the safety of direct oral anticoagulants in hemodialysis patients using national data.

Methods: The National Health Insurance Service database was retrospectively queried to identify chronic kidney disease patients who took direct oral anticoagulants for venous thromboembolism from 2008 to 2019.

Validation of an acute kidney injury prediction model as a clinical decision support system.

Background: Acute kidney injury (AKI) is a critical clinical condition that requires immediate intervention. We developed an artificial intelligence (AI) model called PRIME Solution to predict AKI and evaluated its ability to enhance clinicians' predictions.

Methods: The PRIME Solution was developed using convolutional neural networks with residual blocks on 183,221 inpatient admissions from a tertiary hospital (2013-2017) and externally validated with 4,501 admissions at another tertiary hospital (2020-2021).

Constipation and risk of death and cardiovascular events in patients on hemodialysis.

Background: Constipation is a common gastrointestinal disorder and is often accompanied by alteration in the gut microbiota. Recently, several studies have disclosed its association with an increased risk of cardiovascular disease and mortality in the general population. Despite the high prevalence of constipation, data on the clinical impact of constipation in patients with chronic kidney disease are limited.

Dual-stimuli-responsive nanoparticles for the co-delivery of small molecules to promote neural differentiation of human iPSCs.

The differentiation of human induced pluripotent stem cells (hiPSCs) into neural progenitor cells (NPCs) is a promising approach for the treatment of neurodegenerative diseases and regenerative medicine. Dual-SMAD inhibition using small molecules has been identified as a key strategy for directing the differentiation of hiPSCs into NPCs by regulating specific cell signaling pathways. However, conventional culture methods are time-consuming and exhibit low differentiation efficiency in neural differentiation.

Primary renal BCOR::CCNB3 sarcoma in a female patient: case report.

BCOR-rearranged sarcoma was classified by the World Health Organization in 2020 as a new subgroup of undifferentiated small round-cell sarcoma. It is known to occur very rarely in the kidney. This report presents the first case of a primary renal BCOR::CCNB3 sarcoma in a 22-year-old woman.

Comparison of tissue-based and plasma-based testing for EGFR mutation in non-small cell lung cancer patients.

Background: Epidermal growth factor receptor (EGFR) gene mutation testing is crucial for the administration of tyrosine kinase inhibitors to treat non-small cell lung cancer. In addition to traditional tissue-based tests, liquid biopsies using plasma are increasingly utilized, particularly for detecting T790M mutations. This study compared tissue- and plasma-based EGFR testing methods.

Breast fine-needle aspiration cytology in the era of core-needle biopsy: what is its role?

Fine-needle aspiration cytology (FNAC) has long been recognized as a minimally invasive, cost-effective, and reliable diagnostic tool for breast lesions. However, with the advent of core-needle biopsy (CNB), the role of FNAC has diminished in some clinical settings. This review aims to re-evaluate the diagnostic value of FNAC in the current era, focusing on its complementary use alongside CNB, the adoption of new approaches such as the International Academy of Cytology Yokohama System, and the implementation of rapid on-site evaluation to reduce inadequate sample rates.

Professional biobanking education in Korea based on ISO 20387.

To ensure high-quality bioresources and standardize biobanks, there is an urgent need to develop and disseminate educational training programs in accordance with ISO 20387, which was developed in 2018. The standardization of biobank education programs is also required to train biobank experts. The subdivision of categories and levels of education is necessary for jobs such as operations manager (bank president), quality manager, practitioner, and administrator.

A novel machine learning model for screening the risk of obstructive sleep apnea using craniofacial photography with questionnaires.

Study Objectives: Undiagnosed or untreated moderate to severe obstructive sleep apnea (OSA) increases cardiovascular risks and mortality. Early and efficient detection is critical, given its high prevalence. We aimed to develop a practical and efficient approach for obstructive sleep apnea screening, using simple facial photography and sleep questionnaires.

Clusters of Patient Empowerment and Mental Health Literacy Differentiate Professional Help-Seeking Attitudes in Online Mental Health Communities Users.

Objectives: Grounded in the Health Empowerment Model, which posits that health literacy and patient empowerment are intertwined yet distinct constructs, this study investigates how the interplay of these factors influences attitudes toward seeking professional psychological help in members of online communities for mental health (OCMHs). This while acknowledging the multidimensionality of patient empowerment, encompassing meaningfulness, competence, self-determination, and impact.

Design And Methods: A cluster analysis of data gathered from 269 members of Italian-speaking OCMHs on Facebook has been performed.

The global prevalence of emotional eating in overweight and obese populations: A systematic review and meta-analysis.

This systematic review aims to investigate the current prevalence of emotional eating and its associated factors in overweight and obese populations. We included studies that (1) reported prevalence of emotional eating; (2) were in the context of weight gain or overweight and obesity; (3) used a validated psychometric tool to assess emotional eating; (4) were published as an internationally referred journal article and (5) were reported in the English language. Articles were searched on eight electronic databases (CINAHL, EMBASE, PsychINFO, ProQuest, PubMed, Scopus, The Cochrane Library and Web of Science) from the journals' inception to 11 April 2024.

First-line pembrolizumab-axitinib versus sunitinib in metastatic RCC: subgroup analysis of patients enrolled in the phase 3 KEYNOTE-426 in Eastern Asia.

Background: The phase 3 open-label KEYNOTE-426 study demonstrated that first-line pembrolizumab plus axitinib improved overall survival (OS) and progression-free survival (PFS) versus sunitinib for metastatic renal cell carcinoma (mRCC) in a global population. This subgroup analysis investigated the efficacy and safety of pembrolizumab-axitinib versus sunitinib in patients enrolled in KEYNOTE-426 in East Asia (Japan, South Korea, and Taiwan).

Methods: Adults with clear cell mRCC were randomly assigned 1:1 to receive intravenous pembrolizumab 200 mg every 3 weeks with oral axitinib 5 mg twice daily or oral sunitinib 50 mg once daily (4 weeks on/2 weeks off).

Illness attitudes and the flourishing of university students of South Korea in a pandemic: a cross-sectional descriptive study.

Since the onset of the Coronavirus-19 (COVID-19) pandemic in 2019, the virus has continued to experience periodic resurgences, and the evolution of new variants remains unpredictable. The greatest anxiety in Korean is now related to novel diseases, with a significant increase from 2.9% in 2018 to 32.

Structural Transformation and Degradation of Cu Oxide Nanocatalysts during Electrochemical CO Reduction.

The electrochemical CO reduction reaction (CORR) holds enormous potential as a carbon-neutral route to the sustainable production of fuels and platform chemicals. The durability for long-term operation is currently inadequate for commercialization, however, and the underlying deactivation process remains elusive. A fundamental understanding of the degradation mechanism of electrocatalysts, which can dictate the overall device performance, is needed.

Engineering Yarrowia lipolytica for the production of β-carotene by carbon and redox rebalancing.

Background: β-Carotene is a natural product that has garnered significant commercial interest. Considerable efforts have been made to meet such demand through the metabolic engineering of microorganisms, yet there is still potential for improvement. In this study, engineering approaches including carbon and redox rebalancing were used to maximize β-carotene production in Yarrowia lipolytica.