Vitamin Bs as Potent Anticancer Agents through MMP-2/9 Regulation.

In recent years, the role of coenzymes, particularly those from the vitamin B group in modulating the activity of metalloenzymes has garnered significant attention in cancer treatment strategies. Metalloenzymes play pivotal roles in various cellular processes, including DNA repair, cell signaling, and metabolism, making them promising targets for cancer therapy. This review explores the complex interplay between coenzymes, specifically vitamin Bs, and metalloenzymes in cancer pathogenesis and treatment.

Evaluation of Prediction Models for the Capping and Breaking Force of Tablets Using Machine Learning Tools in Wet Granulation Commercial-Scale Pharmaceutical Manufacturing.

: This study aimed to establish a predictive model for critical quality attributes (CQAs) related to tablet integrity, including tablet breaking force (TBF), friability, and capping occurrence, using machine learning-based models and nondestructive experimental data. : The machine learning-based models were trained on data to predict the CQAs of metformin HCl (MF)-containing tablets using a commercial-scale wet granulation process, and five models were each compared for regression and classification. We identified eight input variables associated with the process and material parameters that control the tableting outcome using feature importance analysis.

Analysis of Reproductive Strategies and Immunological Interactions in -Resistant Japanese Tree Frogs.

The amphibian chytrid fungus, (), has been implicated as an agent of acute declines in amphibian populations worldwide. East Asian amphibians have been coexisting with for long periods and thus are considered resistant; among the many is the Japanese tree frog, . Our study focused infection effects on reproductive behaviors and physiological parameters in as a function of better understanding the chronic effect of the disease on long-term population viability.

Transcriptome analysis of wild soybean (Glycine soja) under salt stress and identification of salt-responsive genes.

Background: Soil salinity has been a serious threat to agricultural production worldwide, including soybeans. Glycine soja, the wild ancestor of cultivated soybeans, harbors high genetic diversity and possesses attractive rare alleles.

Objective: We conducted a transcriptome analysis of G.

National scale evaluation of nutrient purification capacity in marine sediments along the coast of South Korea: A mesocosm study based in situ assessment.

The ecosystem regulating services from tidal flats, such as removal of organic pollutants, provided by natural tidal flats are being increasingly recognized, yet quantitative evaluation remains limited. Here we evaluated a nationwide capacity of natural purification in tidal flats. Using in situ sediments from five along the Korean coast (Incheon, Gunsan, Sinan, Gwangyang, and Busan), we applied a mesocosm system informed by 18 years of riverine monitoring data from national surveys.

Cell deconvolution-based integrated time-series network of whole blood transcriptome reveals systemic antiviral activities and cell-specific immunological changes against PRRSV infection.

Porcine reproductive and respiratory syndrome (PRRS) causes significant economic losses in the swine industry. However, the molecular mechanisms behind the common and cell type-specific systemic responses during PRRS virus (PRRSV) infection are not well understood. In this study, we collected viremia data, antibody levels, and whole-blood RNA-seq data obtained from eight PRRSV-infected piglets.

Physiological effects of suspended sediments on marine fish across habitat, development, and behavioral factors.

This study evaluated the physiological responses of four marine fish species (Lateolabrax japonicus, Sebastes schlegelii, Platichthys stellatus, and Paralichthys olivaceus) to suspended sediments (SS) generated by marine sand mining. Using oxygen consumption rate (OCR), osmolality, and mortality as endpoints, the effects of SS concentrations ranging from 0 to 10,000 mg L were assessed. L.

A Review on the Application of Animal-Based Materials Using Three-Dimensional (3D) Printing and Protein Restructuring Technologies.

Production of alternative proteins is crucial for the development of future protein resources. This study explored the creation of sustainable animal resources by combining extrusion molding and three-dimensional (3D) printing technologies. Extrusion effectively organizes vegetable proteins at high temperatures and pressures to replicate meat-like textures, and high-moisture extrusion successfully mimics the fiber structure of conventional meat.

Scaffolds Bioink for Three-Dimensional (3D) Bioprinting.

Rapid population growth and a corresponding increase in the demand for animal-derived proteins have led to food supply challenges and the need for alternative and sustainable meat production methods. Therefore, this study explored the importance of cell engineering technology-based three-dimensional bioprinting and bioinks, which play key roles in cultured meat production. In cultured meat production, bioinks have a significant effect on cell growth, differentiation, and mechanical stability.

Exploring Sustainable Future Protein Sources.

With the exponential growth of the world population and the decline in agricultural production due to global warming, it is predicted that there will be an inevitable shortage of food and meat resources in the future. The global meat consumption, which reached 328 million tons in 2021, is expected to increase by about 70% by 2050, and the existing livestock industry, which utilizes limited resources, is having difficulty meeting the demand. Accordingly, cultured meat produced by culturing cells in the laboratory, edible insects consumed after cooking or processing, and plant-based meat processed by extracting proteins from plants have been proposed as sustainable food alternatives.

Key risk factors of generalized anxiety disorder in adolescents: machine learning study.

Adolescents worldwide are increasingly affected by mental health disorders, with anxiety disorders, including Generalized Anxiety Disorder (GAD), being particularly prevalent. Despite its significant impact, GAD in adolescents often remains underdiagnosed due to vague symptoms and delayed medical attention, highlighting the need for early diagnosis and prevention strategies. This study utilized data from the Korea Youth Risk Behavior Web-based Survey (KYRBS) from 2020 to 2023 to analyze factors influencing GAD in adolescents.

Factors Associated with the Patient Safety Activities among Home-Visit Caregiver: A Cross-Sectional Study.

Background: Home-visit care should prioritize patient safety and promote positive safety awareness to maintain caregivers' commitment to providing safe care. This descriptive study aims to examine the relationship between home-visit caregivers' knowledge, attitudes, awareness of patient safety, and safety-related activities.

Methods: The participants were 210 adult home-visit caregivers, aged 20 years or older, with more than six months of experience working at six long-term care centers in D Metropolitan City.

Enhancing indigenous plant growth in metal(loid) contaminated soil using biochar.

Soil around mines contaminated with metal(loid) is not suitable for growing plants and it is necessary to select indigenous plants with tolerance for metal(loid) and ameliorate metal toxicity in soil using soil amendments. Therefore, the purpose of this study was to improve the soil environment to make it suitable for plant growth by treating chicken manure derived-biochar in soil contaminated with arsenic (As), cadmium (Cd), and lead (Pb). Biochar application increased soil pH and significantly reduced bioavailable As, Cd and Pb, thereby lowering toxicity in plants.

Data-driven analysis of climate impact on tomato and apple prices using machine learning.

Machine learning has been used in various areas, but there are few studies on price prediction for agricultural products. Here, a machine learning technique for the price prediction of tomato and apple fruits was attempted based on environment and price data for 12 years. The goal of this study is to discover 1) how much can we accurately predict the product prices with the environmental factors and 2) how much each environmental factor affects to the product prices.

Field-based safety evaluation of rVHSV-GΔTM in aquaculture and verification of vaccine efficacy through freeze-dried prototyping in olive flounder.

Single-cycle viruses hold great promise as fish viral vaccines due to their high protective efficacy. Although the efficacy of the vaccine in olive flounder and rainbow trout has been proven through previous research, safety must be additionally proven considering the environment of use for commercialization. This study comprehensively assesses the safety of rVHSV-GΔTM and its impact on both the host and the surrounding environment, including the coastal habitat of nearby species and seawater.

Attitudes and digital health literacy mediate the relationship of digital information accessibility with intention for digital healthcare service use in patients with multiple myeloma: A cross-sectional study.

Purpose: This study aimed to investigate the serial mediating effects of attitudes toward digital healthcare services (ATDH) and digital health literacy (DHL) on the relationship between accessibility of digital information (ADI) and intention to use digital healthcare services (IUDH) among patients with multiple myeloma (MM).

Methods: A cross-sectional questionnaire-based survey was conducted with patients with MM under outpatient follow-up at the cancer center of a university-affiliated hospital in South Korea. Data were collected between September and December 2023 from a convenience sample of 139 patients.

Patient's sexual dignity discomfort in healthcare setting: A concept development.

Body touch and close physical proximity are inevitable in some healthcare procedures and can evoke feelings of shame, humiliation, and anger in patients. Given the increasing recognition of human dignity, exploring the occurrence of these negative emotional experiences and identifying mechanisms for their prevention are crucial. To develop and define the concept of "patient's sexual dignity discomfort.

Morphological and molecular identification of Particolored bat () in South Korea: A first record.

Background belong to the genus and are widely distributed in Europe, the Middle East and Northeast Asia, Recently, the presence of the has been confirmed in Japan, suggesting the possibility of its habitation on the Korean Peninsula. However, ecological information regarding its presence in the Korean Peninsula is extremely limited. New information In an urban area of Sejong City, South Korea, a bat within the genus was rescued by personnel of the Chungnam Wild Animal Rescue Center.

Understanding the adoption intention of financial data retrieval services: An empirical analysis of my data.

This study empirically analyzed the variables affecting the adoption intention of a financial data retrieval service (i.e. My Data) through the convergence of the stimulus-organism-response (S-O-R) model, the value-based adoption model (VAM), and the unified theory of acceptance and use of technology (UTAUT1).

Phase-dependent electronic structure modulation of nickel selenides by Fe doping for enhanced bifunctional oxygen electrocatalysis.

Bifunctional oxygen electrocatalysis is a pivotal process that underpins a diverse array of sustainable energy technologies, including electrolyzers and fuel cells. Metal selenides have been identified as highly promising candidates for oxygen electrocatalysts with electronic structure engineering that lies at the heart of catalyst design. Two-phase Fe-doped nitrogen carbon (NC)-supported nickel selenides were synthesized using a coordination polymer template.

Immunomodulation Effects of Porcine Cartilage Acellularized Matrix (pCAM) for Osteoarthritis Treatment.

Background: Pain reduction, immunomodulation, and cartilage repair are key therapeutic goals in osteoarthritis (OA) treatment. In this study, we evaluated the therapeutic effects of porcine cartilage acellularized matrix (pCAM) derived from naive tissue and compared it with the synthetic material polynucleotides (PN) for OA treatment.

Methods: pCAM was produced from porcine cartilage through physicochemical processing.

The effects of childhood maltreatment and social support on the trajectories of depressive symptoms from adolescence to young adulthood.

Background: Depression is one of the most common mental health concerns among adolescents and young adults. Childhood maltreatment is a particularly potent risk factor for the subsequent development of depressive symptoms. Meanwhile, social support has been identified as a robust protective factor against depressive symptoms.

Effect of electrochemical topology on detection sensitivity in MEA assay for drug-induced cardiotoxicity screening.

Cardiotoxicity remains a major challenge in drug development, accounting for 45% of medication withdrawals due to cardiac ischemia and arrhythmogenicity. To overcome the limitations of traditional multielectrode array (MEA)-based cardiotoxicity assays, we developed a Nafion-coated NanoMEA platform with decoupled reference electrodes, offering enhanced sensitivity for electrophysiological measurements. The 'Decoupled' configuration significantly reduced polarization resistance (Rp) from 12.

Isoniazid and nicotinic hydrazide hybrids mitigate trehalose-6,6'-dimycolate-induced inflammatory responses and pulmonary granulomas via Syk/PI3K pathways: A promising host-directed therapy for tuberculosis.

Granulomas, dense clusters of immune cells and bacteria, are critical barriers in tuberculosis (TB) treatment. Recent advancements in TB management have highlighted granuloma control as a potential host-directed therapy (HDT) strategy. Although isoniazid (INH) is the first-line drug for TB therapy, its efficacy is limited to non-replicating Mycobacterium tuberculosis (Mtb) under granulomatous conditions, necessitating the development of more effective derivatives.