Lopinavir Loaded Spray Dried Liposomes with Penetration Enhancers for Cytotoxic Activity.

Objective: HIV protease inhibitors (HIV-PI) are the drugs utilized for the treatment of HIV. However, their effectiveness is limited due to lack of bioavailability and they need to be coadministered with another drug. In this study single lopinavir (LPV) loaded phospholipid vesicles were prepared by the spray-drying method.