3 results match your criteria: "Kolding Hospital at Lillebaelt Hospital[Affiliation]"
Elevated Bone Remodeling Markers of CTX and P1NP in Addition to Sclerostin in Patients with X-linked Hypophosphatemia: A Cross-Sectional Controlled Study.
Calcif Tissue Int
June 2019
Department of Pediatrics, Kolding Hospital at Lillebaelt Hospital, Kolding, Denmark.
Article Synopsis
- This study investigated bone remodeling in adults with X-linked hypophosphatemia (XLH), comparing biochemical markers with healthy controls.
- Results showed higher levels of bone resorption (CTX) and formation (P1NP), as well as sclerostin, in XLH patients compared to controls, indicating increased osteoblast and osteoclast activity.
- The findings challenge previous research suggesting low remodeling activity in XLH, prompting further investigation into the role of sclerostin and potential osteocyte dysfunction.
Impact of Conventional Medical Therapy on Bone Mineral Density and Bone Turnover in Adult Patients with X-Linked Hypophosphatemia: A 6-Year Prospective Cohort Study.
Calcif Tissue Int
March 2018
Department of Pediatrics, Kolding Hospital at Lillebaelt Hospital, Sygehusvej 24, DK-6000, Kolding, Denmark.
Article Synopsis
- X-linked hypophosphatemia (XLH) is a genetic disorder causing rickets in children and osteomalacia in adults, with treatments including oral phosphate and alfacalcidol recommended for kids but debated for adults.
- A 6-year study involving 27 adult XLH patients compared the effects of ongoing treatment on bone mineral density (aBMD) and key biochemical markers, finding no significant changes in aBMD between treated and untreated groups.
- Although treated patients showed increased bone resorption (as indicated by rising CTX levels), the therapy did not significantly impact bone mass, as aBMD measurements remained stable for both groups over time.
Craniofacial and dental characteristics of patients with vitamin-D-dependent rickets type 1A compared to controls and patients with X-linked hypophosphatemia.
Clin Oral Investig
March 2018
Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark.
Article Synopsis
- - The study investigates craniofacial and dental features in patients with vitamin-D-dependent rickets type 1A (VDDR1A), comparing them to individuals with X-linked hypophosphatemia (XLH) and healthy adults.
- - Results show that VDDR1A patients have specific cranial measurements and a higher prevalence of enamel hypoplasia compared to XLH patients, indicating more severe dental abnormalities.
- - The findings suggest that nutritional deficits in both calcium and phosphate play a significant role in the dental health of VDDR1A patients, underscoring the importance of this knowledge for dental practitioners working with rare disease patients.