1,893 results match your criteria: "Koirala Institute of Health Sciences[Affiliation]"

Background: The International Society of Nephrology proposes an acute kidney disease (AKD) management strategy that includes a risk score to aid AKD identification in low- and low-middle-income countries (LLMICs). We investigated the performance of the risk score and determined kidney and patient outcomes from AKD at multiple LLMIC sites.

Methods And Findings: Adult patients presenting to healthcare facilities in Bolivia, Brazil, South Africa, and Nepal were screened using a symptom-based risk score and clinical judgment.

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Background And Objectives: Cardiovascular diseases (CVDs) are main cause of mortality and morbidity among women globally. Menopause, aging and different factors in collaboration leads to increased risk for CVDs among postmenopausal women but study on risk factors of CVDs among postmenopausal women is limited in Nepal. Therefore, we aimed to assess prevalence of behavioural and metabolic risk factors of cardiovascular disease among post-menopausal women.

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Introduction And Importance: Ascariasis lumbricoides is a common gastrointestinal tract helminthic disease in developing countries and is also a cause of hepatobiliary and pancreatic disease in endemic areas of the world. Involvement of the pancreatic duct by worms and associated pancreatitis is less common than the hepatic and biliary involvement.

Case Presentation: A 38-year-old patient was admitted with a diagnosis of alcohol-induced acute pancreatitis and managed conservatively.

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Introduction And Importance: Self-inflicted abdominal stab wounds present rare yet critical challenges requiring urgent surgical intervention and comprehensive psychiatric evaluation. Such injuries often correlate with psychiatric disorders like schizophrenia and alcohol dependence, posing significant clinical and psychological management hurdles.

Case Presentation: A 36-year-old male with a history of chronic alcohol use and schizophrenia presented with a self-inflicted stab wound to the abdomen following auditory hallucinations.

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This article explores the potential of telemedicine to revolutionize maternal and perinatal healthcare delivery in rural Nepal, where access to medical facilities is limited. By utilizing telemedicine technologies like remote consultations, mobile health applications, and tele-ultrasound, the authors can overcome barriers to healthcare access and improve outcomes for expectant mothers and newborns. The paper assesses the opportunities presented by telemedicine interventions and addresses the challenges that must be addressed for successful integration into rural healthcare systems.

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Introduction: Stevens-Johnson Syndrome (SJS) is a rare but severe mucocutaneous reaction often triggered by medications or infections, characterized by extensive epidermal detachment and mucosal involvement. This condition poses a high risk of morbidity and mortality, requiring prompt recognition and treatment.

Case Presentation: An 18-year-old Asian female from eastern Nepal presented with nonitchy red spots, high fever, and significant discomfort following the administration of ibuprofen for minor sores.

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Introduction And Importance: Dermatomyositis (DM) is an autoimmune disorder affecting all age groups, with a higher prevalence in women. Diagnosis typically occurs around age 40. Manifestation can be acute or chronic.

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Introduction: Thoracolumbar fractures make up majority of the spinal fractures. Various techniques including long, short, mono and short segment screw fixation have been used to achieve stability. There are still few studies describing the results of short segment fixation with intermediate screw fixation in fractured vertebrae, despite the fact that all have adequate efficacy and stability.

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Introduction And Importance: Transorbital penetrating traumatic brain injury (TPTBI) is a rare cause of penetrating head injury, yet the diagnoses can be overlooked in some cases due to incomplete history, trivial trauma, and the absence of immediate neurologic deficits.

Case Presentation: A 4-year-old male child was admitted with a diagnosis of TPTBI by a wooden object. Noncontrast enhanced CT scan revealed a linear hypodense structure extending from the superior wall of the right orbit into the frontal lobe with displaced fragments into the brain.

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Key Clinical Message: Normal pressure hydrocephalus is rarely associated with Belly dancer's dyskinesia and seizure.

Abstract: Belly dancer's dyskinesia (BDD) is characterized by bilateral, sluggish, involuntary, repetitive, and rhythmic motions of the anterior abdominal wall. We present a rare case of a 78-year-old man diagnosed with normal pressure hydrocephalus associated with BDD and seizure who presented with left-sided weakness of the body and abnormal body movements.

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Objective: The purpose of this retrospective analysis was to evaluate the clinical presentations, radiological characteristics, patient outcomes, and therapeutic approaches among individuals diagnosed with primary central nervous system lymphoma (PCNSL), high-grade glioma (HGG), and metastatic brain tumors (METS).

Methods: We assembled a cohort of brain tumor patients from two medical centers, with two oncologists independently reviewing their clinical profiles. A retrospective examination of 87 PCNSL, 87 HGG, and 71 METS cases was performed to assess the aforementioned parameters.

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A Brief History and the Use of PET in the Diagnosis and Management of Schizophrenia: An Educational Review.

PET Clin

January 2025

Division for Technology and Innovation, The Intervention Center, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway. Electronic address:

This article explores the role of PET in the diagnosis and treatment of schizophrenia. PET imaging can reveal neurobiologic aspects such as cerebral blood flow, glucose metabolism, receptor function, and neuroinflammation in schizophrenia. It has supported the dopaminergic hypothesis and helped distinguish symptom types and severity.

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Global multi-societies endorsement of the MAFLD definition.

Ann Hepatol

January 2024

Department of Gastroenterology, Hepatology and Endemic Medicine, Faculty of Medicine, Minia University, Cairo, Egypt.; Egyptian MAFLD research group (EMRG).

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Article Synopsis
  • The shock index (SI), calculated by heart rate divided by systolic blood pressure, is linked to adverse maternal outcomes, particularly in obstetric cases where SI ≥ 0.9 is noted.
  • In this study, researchers analyzed the relationship between baseline SI and hypotension after spinal anesthesia in parturients undergoing non-elective cesarean sections, using logistic regression for data analysis.
  • The findings revealed that a higher baseline SI was significantly associated with both post-spinal and post-delivery hypotension, indicating that SI could be a useful metric for predicting these complications in surgery.
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Key Clinical Message: Spontaneous rectus sheath hematoma is a rare complication in chronic liver disease patients. Early clinical suspicion with prompt radiological evaluation is crucial for accurate diagnosis and timely management.

Abstract: Spontaneous rectus sheath hematoma can present as an acute abdomen in the emergency department.

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Since 1883, "tennis leg" has described various acute calf injuries linked to activities such as tennis serving or stair climbing. Current research suggests that tennis leg is caused by the injury of the medial head of the gastrocnemius muscle. This case report details the case of a 35-year-old male who suffered sudden and intense calf pain after a minor leg extension injury.

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Article Synopsis
  • Clinical trials (CT) are essential for developing new medicines and require participant involvement, which is influenced by their attitudes and understanding of the trials.
  • A study at B.P. Koirala Institute of Health Sciences in Nepal assessed the knowledge and perceptions of 622 participants in a phase III CT, finding that a vast majority were literate, of indigenous backgrounds, and had not participated in a CT before.
  • Results showed that 91% of participants had adequate knowledge and 95.7% had a positive perception of CT, with most joining for disease protection and believing the trials benefit humanity, suggesting the need for future studies on knowledge before and after participation.
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Introduction: DLBCL with gastrointestinal involvement is a relatively rare form of extra-nodal lymphoma, and complications such as spontaneous perforation and jejunal stricture in this disease are even rarer.

Case Presentation: A 45-year-old male presented with abdominal pain and vomiting. Diagnosis revealed a jejunal stricture with perforation, necessitating resection and anastomosis.

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Article Synopsis
  • Histopathological diagnosis is crucial for identifying oral and maxillofacial conditions, but accurate clinical descriptions are essential for proper diagnosis.
  • A study analyzed 338 biopsy request forms to assess the agreement between clinical and histopathological diagnoses, finding a 71.89% total concordance rate, though some forms lacked critical clinical details.
  • The study concluded that good levels of agreement exist between diagnoses, emphasizing the importance of thorough clinical information on requisition forms for improving diagnostic accuracy.
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Injuries to blood vessels occur in 0.8% of the cases following laparoscopic cholecystectomy. They may result from direct penetration while insertion of trocar or by thermal injury (electrocautery).

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Article Synopsis
  • Gastroepiploic artery aneurysms (GEAAs) are a rare type of splanchnic artery aneurysms, with a prevalence of only 0.4% among all SAAs, and are most commonly caused by factors like atherosclerosis, trauma, and infections.
  • A case study detailed a 35-year-old female with no significant medical history who experienced shock due to a spontaneously ruptured right gastroepiploic artery aneurysm, detected via a CECT scan.
  • GEAAs are more common in males and tend to rupture after age 50, making spontaneous ruptures in younger females extremely rare, necessitating urgent surgical treatment due to associated high risks of mortality
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