Computational modeling design of novel NMDAR agonist for the treatment of Schizophrenia.

Schizophrenia (SZ) is a complex, chronic mental disorder characterized by positive symptoms (such as delusions and hallucinations), negative symptoms (including anhedonia, alogia, avolition, and social withdrawal), and cognitive deficits (affecting attention, processing speed, verbal and visuospatial learning, problem-solving, working memory, and mental flexibility). Extensive animal and clinical studies have emphasized the NMDAR hypofunction hypothesis of SZ. Glycine plays a crucial role as an agonist of NMDAR, enhancing the receptor's affinity for glutamate and supporting normal synaptic function and plasticity, that is, signal transmission between neurons.

Detection of diarrhoeagenic Escherichia coli in the abattoir wastewater-impacted Iyi-Etu River and other water types at the Amansea livestock market settlement, Anambra State, Nigeria: a matter of public health concern.

Background: Globally, diarrhoeagenic Escherichia coli (DEC) has been implicated in the spread of waterborne diseases and abattoir wastewater has played a role in its dissemination into watersheds. This study isolated and characterised DEC from the abattoir wastewater-impacted Iyi-Etu River and other water sources at the Amansea livestock market settlement.

Methods: A total of 96 water samples comprising river water (upstream, downstream 1, downstream 2), borehole, well, sachet and abattoir wastewater samples were tested for DEC.

Detection and Molecular Characterization of from Wastewater Environments in Two University Campuses in Nigeria.

Background: () is the most prominent bacterial pathogen that causes urinary tract infections (UTIs), and the rate of resistance to most used antibiotics is alarmingly increasing.

Methods: This study assessed the hostel gutters of two Nigerian universities, the University of Nigeria, Nsukka (UNN) and Kogi State University, Anyigba (KSU), for and its antimicrobial resistance genes (). Oxoid Chromogenic UTI agar was used to isolate uropathogenic (UPEC), identified using standard biochemical tests.

Beyond the blade: Unveiling the nexus of spirituality and human dissection among medical and allied health students in Nigeria.

This study investigated how human dissection affects students' spiritual beliefs, and how their existing spiritual beliefs influence their perceptions of human dissection. This cross-sectional study assessed 760 medical students with human dissection experience using an online questionnaire developed from interviews and the Spirituality Orientation Inventory, including questions on dissection experience, spirituality, spiritual perceptions about dissection, and the impact of dissection on spirituality. Descriptive analysis and Chi-squared tests were used to determine proportions and relationships between variables, with statistical significance at p < 0.

Visceral adiposity index, cardiorespiratory fitness, and fasting plasma glucose associations in adolescents.

Background: The global rise in the prevalence of type 2 diabetes mellitus (T2DM) in children and adolescents is partly linked to the increasing rates of childhood obesity and physical inactivity.

Aim: To explore the independent relationships of visceral adiposity index (VAI) and cardiorespiratory fitness (CRF) with fasting plasma glucose (FPG) in adolescents.

Methods: This descriptive cross-sectional study included 403 adolescents (202 boys and 201 girls) aged 11-19 years.

Relativistic bound state solutions and quantum information theory in D dimensions under exponential-type plus Yukawa potentials.

The bound-state solution of the radial Klein-Gordon equation has been obtained under the interaction of an exponential-type and Yukawa potential functions. The Greene-Aldrich approximation has been used to overcome the centrifugal barrier and enable the analytical solutions of the energy and wave functions in closed form. The momentum space wave function in D dimensions has been constructed using the Fourier transform.

Evaluation of gold mineralisation potential using AHP systems and weighted overlay analysis.

The demand for sustainable development goals and the absence of systematic development and organised exploration for gold has prompted this study to integrate magnetic and radiometric datasets with lithology to evaluate the gold mineralisation potential in the Ilesha schist belt. This study considers 3168.72 km of the Ilesha schist belt in southwestern Nigeria, a frontier belt for gold deposits.

Comorbidities and Monitoring in Patients with Chronic Hepatitis B on Nucleos(t)ide Analogues Attending a Tertiary Hospital in Malaysia, Southeast Asia: A Critical Perspective.

Background: Chronic hepatitis B (CHB) is a significant global public health concern in Malaysia. It is a potentially life-threatening liver disease caused by the hepatitis B virus (HBV), which can lead to long-term complications such as cirrhosis, liver failure and hepatocellular carcinoma. In managing CHB, nucleos(t)ide analogues (NAs) have become the preferred treatment due to their ability to suppress viral replication and prevent disease progression.

Erythromycin-metal complexes: One-step synthesis, molecular docking analysis and antibacterial proficiency against pathogenic strains.

The study focused on the extraction of free erythromycin from commercially manufactured tablets and the use of metal salts to synthesize erythromycin-metal complexes, specifically involving silver (Ag), nickel (Ni), cobalt (Co), and copper (Cu). The synthesis was confirmed through various methods, including elemental analysis, thermogravimetric analysis, Fourier-transform infrared (FTIR), and UV-visible spectroscopy. The microbiological investigation involved and as test organisms.

Visceral adiposity index, fitness and clustered cardiovascular disease risk in adolescents.

Background:  Clustering of cardiovascular disease (CVD) risk factors have been observed in children and adolescents, but its association with visceral adiposity index (VAI) and cardiorespiratory fitness (CRF) in adolescents has rarely been studied.

Aim:  This study determines the independent associations of VAI and CRF with the clustering of cardiovascular disease risk (CVDr) among Nigerian adolescents.

Setting:  Adolescents from specific secondary schools in Kogi East, North Central Nigeria participated in the study.

Noroviruses: Evolutionary Dynamics, Epidemiology, Pathogenesis, and Vaccine Advances-A Comprehensive Review.

Noroviruses constitute a significant aetiology of sporadic and epidemic gastroenteritis in human hosts worldwide, especially among young children, the elderly, and immunocompromised patients. The low infectious dose of the virus, protracted shedding in faeces, and the ability to persist in the environment promote viral transmission in different socioeconomic settings. Considering the substantial disease burden across healthcare and community settings and the difficulty in controlling the disease, we review aspects related to current knowledge about norovirus biology, mechanisms driving the evolutionary trends, epidemiology and molecular diversity, pathogenic mechanism, and immunity to viral infection.

Chemical fractionation and mobility of Cd, Mn, Ni, and Pb in farmland soils near a ceramics company.

Soil contamination due to industrial activity in ceramics production is of concern because of the risk of heavy metal pollution. Successive extraction was used to measure and identify the concentrations of Cd, Mn, Ni, and Pb in farming soils near a ceramics company in Nigeria. Furthermore, soil pH and particle size analyses were determined.

Heavy metal pollution indices in soil and plants within the vicinity of the Gosa Dumpsite in Abuja, Nigeria.

Heavy metal contamination in the soil and phytoremediation potential of the plants cultivated around the Gosa dumpsite were evaluated using pollution indices. The concentrations of heavy metals in the soil and plant samples were determined using an atomic absorption spectrophotometer (Agilent 280FS AA). The mean heavy metal contents in the upper and lower soil layers ranged from 0.

Development and Evaluation of PEG-gelatin-based Microparticles to Enhance the Oral Delivery of Insulin.

Background: Diabetes mellitus is a global disease identified by hyperglycemia due to defects in insulin secretion, insulin action, or both.

Objective: The main objective of this research was to evaluate the ability of gelatinized Poly(ethylene glycol) (PEG) microparticles to be used as carriers for oral insulin delivery via double emulsion preparation.

Methods: Five different batches of the formulation consisting of gelatin:PEG were prepared as follows: 0:1 (W1), 1:0 (W2), 1:1 (W3), 1:3 (W4), and 3:1 (W5).

Seroprevalence and co-infection of HBV, HCV, and HIV among patients visiting selected hospitals in Anyigba, Kogi State.

Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), and Human Immunodeficiency Virus (HIV) remain a public health challenge globally. This study determined the prevalence and coinfection of HBV, HCV, and HIV among patients visiting Maria Goretti Hospital, Grimard Catholic Hospital, and Good News Hospital Anyigba, Kogi State. In a cross-sectional study, sera samples collected from 400 consenting patients were screened for HBV, HCV, and HIV using commercial immunodiagnostic test kits.

Approximate solutions of the spin and pseudospin symmetries under coshine Yukawa tensor interaction.

The approximate solutions of the Dirac equation for spin symmetry and pseudospin symmetry are studied with a coshine Yukawa potential model via the traditional supersymmetric approach (SUSY). To remove the degeneracies in both the spin and pseudospin symmetries, a coshine Yukawa tensor potential is proposed and applied to both the spin symmetry and the pseudospin symmetry. The proposed coshine tensor potential removes the energy degenerate doublets in both the spin symmetry and pseudospin symmetry for a very small value of the tensor strength (H = 0.

Selenosalicylate; a little-studied heavy-element analogue of the versatile thiosalicylate ligand.

Selenosalicylic acid (-HSeCHCOH), the heavy element congener of the widely studied thiosalicylic acid, was prepared by reaction of 2-carboxybenzenediazonium chloride (HOCCHNCl) with NaSe, followed by reduction of the resulting diselenide (SeCHCOH) with zinc and acetic acid. The coordination chemistry of the selenosalicylate ligand towards a variety of platinum(ii), palladium(ii), nickel(ii), gold(iii), gold(i), rhodium(iii), iridium(iii) and ruthenium(ii) centres was explored. X-ray crystal structure determinations were carried out on the complexes [Pt(SeCHCO)(PPh)], [{(-cym)Ru(SeCHCO)}] (-cym = η--cymene, CHCHCH(CH)), [{Cp*Rh(SeCHCO)}] (Cp* = η-CMe) and [Cp*Ir(SeCHCO)(PPh)], and comparisons are made with corresponding thiosalicylate complexes.

Evaluating the impact of using storytelling and visual multimedia music intervention to improve knowledge of the Child Rights Act and reduce the propensity to engage in child marriage.

Child marriage has continued to rear its ugly head in Nigerian society. This study aimed to evaluate the impact of storytelling and multimedia music interventions in improving knowledge of the Child Rights Act and reducing the propensity to engage in child marriage. The researchers applied a quasi-experimental design and collected data using a structured questionnaire.

Rhodanine-benzamides as potential hits for α-amylase enzyme inhibitors and radical (DPPH and ABTS) scavengers.

A series of 3-substituted and 3,5-disubstituted rhodanine-based derivatives were synthesized from 3-aminorhodanine and examined for α-amylase inhibitory, DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging activities in vitro. These derivatives displayed significant α-amylase inhibitory potential with IC values of 11.01-56.

Non-relativistic energy equations for diatomic molecules constrained in a deformed hyperbolic potential function.

Context: In this paper, the approximate analytical energy equations for the deformed hyperbolic potential have been obtained for arbitrary parameters of the potential. The potential function was transformed to a molecular potential by subjecting it to the Varshni conditions which allows for the determination of the energy levels of diatomic molecules. The molecular vibrational energy spectra for [Formula: see text], [Formula: see text], [Formula: see text], [Formula: see text], and [Formula: see text] diatomic molecules were obtained and found to match with the results obtained with another analytical approach, potential functions, and experimental data.

Bound-state energy spectrum and thermochemical functions of the deformed Schiöberg oscillator.

In this study, a diatomic molecule interacting potential such as the deformed Schiöberg oscillator (DSO) have been applied to diatomic systems. By solving the Schrödinger equation with the DSO, analytical equations for energy eigenvalues, molar entropy, molar enthalpy, molar Gibbs free energy and constant pressure molar heat capacity are obtained. The obtained equations were used to analyze the physical properties of diatomic molecules.

Prevalence of Hepatocellular Carcinoma in Hepatitis B Population within Southeast Asia: A Systematic Review and Meta-Analysis of 39,050 Participants.

Background And Aim: Hepatocellular carcinoma (HCC) is a significant complication of hepatitis B and still poses a global public health concern. This systematic review and meta-analysis provide adequate details on the prevalence of HCC in the HBV population within Southeast Asian countries.

Method: Following the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) criteria, a thorough search for literature discussing the prevalence of HCC in the HBV population within southeast Asia was performed.

Association of adiposity and fitness with triglyceride-to-high-density lipoprotein cholesterol ratio in youth.

Background: The ratio of triglycerides-to-high-density lipoprotein cholesterol (TG/HDL-C) is considered a robust biomarker of metabolic syndrome (MetS) and is associated with several diseases, including type 2 diabetes mellitus (T2DM) and hypertension (HTN). This study examined the independent association of adiposity and fitness with the TG/HDL-C ratio.

Materials And Methods: This is a cross-sectional study comprising 403 (201 girls) Nigerian adolescents aged 11-19 years.